Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5LRJ

Crystal structure of the porcine carboxypeptidase B - Anabaenopeptin C complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004181	molecular_function	metallocarboxypeptidase activity
A	0006508	biological_process	proteolysis
A	0008270	molecular_function	zinc ion binding
B	0004181	molecular_function	metallocarboxypeptidase activity
B	0006508	biological_process	proteolysis
B	0008270	molecular_function	zinc ion binding
C	0004181	molecular_function	metallocarboxypeptidase activity
C	0006508	biological_process	proteolysis
C	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue ZN A 401

Chain	Residue
A	HIS69
A	GLU72
A	HIS196
F	73P1
F	HOH103

site_id	AC2
Number of Residues	5
Details	binding site for residue ZN B 401

Chain	Residue
G	HOH102
B	HIS69
B	GLU72
B	HIS196
G	73P1

site_id	AC3
Number of Residues	5
Details	binding site for residue ZN C 401

Chain	Residue
C	HIS69
C	GLU72
C	HIS196
H	73P1
H	HOH102

site_id	AC4
Number of Residues	23
Details	binding site for Di-peptide 73P F 1 and DLY F 2

Chain	Residue
A	HIS69
A	ARG71
A	ARG127
A	ASN144
A	ARG145
A	SER197
A	TYR198
A	SER199
A	SER207
A	TYR248
A	ASP255
A	THR268
A	GLU270
A	PHE279
A	ZN401
A	HOH562
F	VAL3
F	73O4
F	MAA5
F	PHE6
F	HOH103
F	HOH104
F	HOH106

site_id	AC5
Number of Residues	17
Details	binding site for Di-peptide DLY F 2 and VAL F 3

Chain	Residue
A	ARG71
A	ARG127
A	ARG145
A	THR164
A	SER197
A	TYR198
A	SER199
A	TYR248
A	PHE279
F	73P1
F	73O4
F	MAA5
F	PHE6
F	HOH103
F	HOH104
F	HOH105
F	HOH106

site_id	AC6
Number of Residues	16
Details	binding site for Di-peptide DLY F 2 and PHE F 6

Chain	Residue
A	ARG71
A	ARG127
A	SER197
A	TYR198
A	SER199
A	TYR248
A	PHE279
F	73P1
F	VAL3
F	73O4
F	MAA5
F	HOH101
F	HOH103
F	HOH104
F	HOH106
F	HOH112

site_id	AC7
Number of Residues	13
Details	binding site for Di-peptide VAL F 3 and 73O F 4

Chain	Residue
A	ARG71
A	MET125
A	ARG127
A	ARG145
A	GLU163
A	THR164
A	TYR248
F	73P1
F	DLY2
F	MAA5
F	PHE6
F	HOH102
F	HOH105

site_id	AC8
Number of Residues	10
Details	binding site for residues 73O F 4 and MAA F 5

Chain	Residue
A	ARG71
A	MET125
A	GLU163
F	DLY2
F	VAL3
F	PHE6
F	HOH102
F	HOH105
F	HOH106
F	HOH107

site_id	AC9
Number of Residues	8
Details	binding site for Di-peptide MAA F 5 and PHE F 6

Chain	Residue
F	HOH106
F	HOH107
F	HOH112
A	TYR248
F	DLY2
F	VAL3
F	73O4
F	HOH101

site_id	AD1
Number of Residues	20
Details	binding site for Di-peptide 73P G 1 and DLY G 2

Chain	Residue
B	HIS69
B	ARG71
B	ARG127
B	ASN144
B	ARG145
B	TYR198
B	SER207
B	TYR248
B	ASP255
B	GLU270
B	PHE279
B	ZN401
B	HOH587
B	HOH681
G	VAL3
G	73O4
G	MAA5
G	PHE6
G	HOH101
G	HOH102

site_id	AD2
Number of Residues	14
Details	binding site for Di-peptide DLY G 2 and VAL G 3

Chain	Residue
B	ARG71
B	ARG127
B	ARG145
B	GLU163
B	THR164
B	TYR198
B	TYR248
B	PHE279
B	HOH587
G	73P1
G	73O4
G	MAA5
G	PHE6
G	HOH102

site_id	AD3
Number of Residues	16
Details	binding site for Di-peptide DLY G 2 and PHE G 6

Chain	Residue
B	ARG71
B	ARG127
B	TYR198
B	TYR248
B	PHE279
B	HOH587
B	HOH993
C	LEU308
C	HOH708
G	73P1
G	VAL3
G	73O4
G	MAA5
G	HOH102
G	HOH103
G	HOH105

site_id	AD4
Number of Residues	15
Details	binding site for Di-peptide VAL G 3 and 73O G 4

Chain	Residue
B	GLU16
B	ARG71
B	MET125
B	ARG127
B	ARG145
B	GLU163
B	THR164
B	TYR248
B	HOH530
G	73P1
G	DLY2
G	MAA5
G	PHE6
G	HOH104
G	HOH107

site_id	AD5
Number of Residues	11
Details	binding site for residues 73O G 4 and MAA G 5

Chain	Residue
B	GLU16
B	ARG71
B	MET125
B	GLU163
B	HOH530
C	HOH620
G	DLY2
G	VAL3
G	PHE6
G	HOH104
G	HOH107

site_id	AD6
Number of Residues	10
Details	binding site for Di-peptide MAA G 5 and PHE G 6

Chain	Residue
B	TYR248
B	HOH993
C	LEU308
C	HOH620
C	HOH708
G	DLY2
G	VAL3
G	73O4
G	HOH103
G	HOH105

site_id	AD7
Number of Residues	19
Details	binding site for Di-peptide 73P H 1 and DLY H 2

Chain	Residue
C	HIS69
C	ARG71
C	ARG127
C	ASN144
C	ARG145
C	TYR198
C	SER207
C	TYR248
C	ASP255
C	GLU270
C	PHE279
C	ZN401
C	HOH548
C	HOH562
H	VAL3
H	73O4
H	MAA5
H	PHE6
H	HOH102

site_id	AD8
Number of Residues	13
Details	binding site for Di-peptide DLY H 2 and PHE H 6

Chain	Residue
C	ARG71
C	ARG127
C	TYR198
C	TYR248
C	PHE279
C	HOH548
C	HOH562
C	HOH890
H	73P1
H	VAL3
H	73O4
H	MAA5
H	HOH102

site_id	AD9
Number of Residues	15
Details	binding site for Di-peptide DLY H 2 and VAL H 3

Chain	Residue
C	ARG71
C	ARG127
C	ARG145
C	GLU163
C	THR164
C	TYR198
C	TYR248
C	PHE279
C	HOH548
C	HOH562
H	73P1
H	73O4
H	MAA5
H	PHE6
H	HOH102

site_id	AE1
Number of Residues	16
Details	binding site for Di-peptide VAL H 3 and 73O H 4

Chain	Residue
C	GLU16
C	ARG71
C	MET125
C	ARG127
C	ARG145
C	GLU163
C	THR164
C	TYR248
C	HOH505
H	73P1
H	DLY2
H	MAA5
H	PHE6
H	HOH101
H	HOH103
H	HOH104

site_id	AE2
Number of Residues	11
Details	binding site for residues 73O H 4 and MAA H 5

Chain	Residue
C	GLU16
C	ARG71
C	MET125
C	GLU163
C	HOH505
H	DLY2
H	VAL3
H	PHE6
H	HOH101
H	HOH103
H	HOH104

site_id	AE3
Number of Residues	5
Details	binding site for Di-peptide MAA H 5 and PHE H 6

Chain	Residue
C	TYR248
C	HOH890
H	DLY2
H	VAL3
H	73O4

Functional Information from PROSITE/UniProt

site_id	PS00132
Number of Residues	23
Details	CARBOXYPEPT_ZN_1 Zinc carboxypeptidases, zinc-binding region 1 signature. PaIfMdcGfHArEwISHafcqwF

Chain	Residue	Details
A	PRO60-PHE82

site_id	PS00133
Number of Residues	11
Details	CARBOXYPEPT_ZN_2 Zinc carboxypeptidases, zinc-binding region 2 signature. HSYSQMIlYPY

Chain	Residue	Details
A	HIS196-TYR206

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255\|PROSITE-ProRule:PRU01379

Chain	Residue	Details
A	GLU270
B	GLU270
C	GLU270

site_id	SWS_FT_FI2
Number of Residues	9
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU01379

Chain	Residue	Details
A	HIS69
A	GLU72
A	HIS196
B	HIS69
B	GLU72
B	HIS196
C	HIS69
C	GLU72
C	HIS196

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P00730

Chain	Residue	Details
A	ARG127
C	ASN144
C	SER197
C	TYR248
A	ASN144
A	SER197
A	TYR248
B	ARG127
B	ASN144
B	SER197
B	TYR248
C	ARG127

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)