Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5LDZ

Quadruple space group ambiguity due to rotational and translational non-crystallographic symmetry in human liver fructose-1,6-bisphosphatase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0003824	molecular_function	catalytic activity
A	0005515	molecular_function	protein binding
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0005986	biological_process	sucrose biosynthetic process
A	0006000	biological_process	fructose metabolic process
A	0006002	biological_process	fructose 6-phosphate metabolic process
A	0006094	biological_process	gluconeogenesis
A	0006111	biological_process	regulation of gluconeogenesis
A	0008152	biological_process	metabolic process
A	0016208	molecular_function	AMP binding
A	0016311	biological_process	dephosphorylation
A	0016787	molecular_function	hydrolase activity
A	0016791	molecular_function	phosphatase activity
A	0030308	biological_process	negative regulation of cell growth
A	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
A	0031667	biological_process	response to nutrient levels
A	0032869	biological_process	cellular response to insulin stimulus
A	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
A	0042578	molecular_function	phosphoric ester hydrolase activity
A	0042802	molecular_function	identical protein binding
A	0045820	biological_process	negative regulation of glycolytic process
A	0046580	biological_process	negative regulation of Ras protein signal transduction
A	0046872	molecular_function	metal ion binding
A	0048029	molecular_function	monosaccharide binding
A	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
A	0070062	cellular_component	extracellular exosome
A	0071286	biological_process	cellular response to magnesium ion
A	0071320	biological_process	cellular response to cAMP
A	0071466	biological_process	cellular response to xenobiotic stimulus
A	0071475	biological_process	cellular hyperosmotic salinity response
A	0071477	biological_process	cellular hypotonic salinity response
A	0097403	biological_process	cellular response to raffinose
A	1904628	biological_process	cellular response to phorbol 13-acetate 12-myristate
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0003824	molecular_function	catalytic activity
B	0005515	molecular_function	protein binding
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005975	biological_process	carbohydrate metabolic process
B	0005986	biological_process	sucrose biosynthetic process
B	0006000	biological_process	fructose metabolic process
B	0006002	biological_process	fructose 6-phosphate metabolic process
B	0006094	biological_process	gluconeogenesis
B	0006111	biological_process	regulation of gluconeogenesis
B	0008152	biological_process	metabolic process
B	0016208	molecular_function	AMP binding
B	0016311	biological_process	dephosphorylation
B	0016787	molecular_function	hydrolase activity
B	0016791	molecular_function	phosphatase activity
B	0030308	biological_process	negative regulation of cell growth
B	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
B	0031667	biological_process	response to nutrient levels
B	0032869	biological_process	cellular response to insulin stimulus
B	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
B	0042578	molecular_function	phosphoric ester hydrolase activity
B	0042802	molecular_function	identical protein binding
B	0045820	biological_process	negative regulation of glycolytic process
B	0046580	biological_process	negative regulation of Ras protein signal transduction
B	0046872	molecular_function	metal ion binding
B	0048029	molecular_function	monosaccharide binding
B	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
B	0070062	cellular_component	extracellular exosome
B	0071286	biological_process	cellular response to magnesium ion
B	0071320	biological_process	cellular response to cAMP
B	0071466	biological_process	cellular response to xenobiotic stimulus
B	0071475	biological_process	cellular hyperosmotic salinity response
B	0071477	biological_process	cellular hypotonic salinity response
B	0097403	biological_process	cellular response to raffinose
B	1904628	biological_process	cellular response to phorbol 13-acetate 12-myristate
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0003824	molecular_function	catalytic activity
C	0005515	molecular_function	protein binding
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005975	biological_process	carbohydrate metabolic process
C	0005986	biological_process	sucrose biosynthetic process
C	0006000	biological_process	fructose metabolic process
C	0006002	biological_process	fructose 6-phosphate metabolic process
C	0006094	biological_process	gluconeogenesis
C	0006111	biological_process	regulation of gluconeogenesis
C	0008152	biological_process	metabolic process
C	0016208	molecular_function	AMP binding
C	0016311	biological_process	dephosphorylation
C	0016787	molecular_function	hydrolase activity
C	0016791	molecular_function	phosphatase activity
C	0030308	biological_process	negative regulation of cell growth
C	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
C	0031667	biological_process	response to nutrient levels
C	0032869	biological_process	cellular response to insulin stimulus
C	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
C	0042578	molecular_function	phosphoric ester hydrolase activity
C	0042802	molecular_function	identical protein binding
C	0045820	biological_process	negative regulation of glycolytic process
C	0046580	biological_process	negative regulation of Ras protein signal transduction
C	0046872	molecular_function	metal ion binding
C	0048029	molecular_function	monosaccharide binding
C	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
C	0070062	cellular_component	extracellular exosome
C	0071286	biological_process	cellular response to magnesium ion
C	0071320	biological_process	cellular response to cAMP
C	0071466	biological_process	cellular response to xenobiotic stimulus
C	0071475	biological_process	cellular hyperosmotic salinity response
C	0071477	biological_process	cellular hypotonic salinity response
C	0097403	biological_process	cellular response to raffinose
C	1904628	biological_process	cellular response to phorbol 13-acetate 12-myristate
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0003824	molecular_function	catalytic activity
D	0005515	molecular_function	protein binding
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005975	biological_process	carbohydrate metabolic process
D	0005986	biological_process	sucrose biosynthetic process
D	0006000	biological_process	fructose metabolic process
D	0006002	biological_process	fructose 6-phosphate metabolic process
D	0006094	biological_process	gluconeogenesis
D	0006111	biological_process	regulation of gluconeogenesis
D	0008152	biological_process	metabolic process
D	0016208	molecular_function	AMP binding
D	0016311	biological_process	dephosphorylation
D	0016787	molecular_function	hydrolase activity
D	0016791	molecular_function	phosphatase activity
D	0030308	biological_process	negative regulation of cell growth
D	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
D	0031667	biological_process	response to nutrient levels
D	0032869	biological_process	cellular response to insulin stimulus
D	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
D	0042578	molecular_function	phosphoric ester hydrolase activity
D	0042802	molecular_function	identical protein binding
D	0045820	biological_process	negative regulation of glycolytic process
D	0046580	biological_process	negative regulation of Ras protein signal transduction
D	0046872	molecular_function	metal ion binding
D	0048029	molecular_function	monosaccharide binding
D	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
D	0070062	cellular_component	extracellular exosome
D	0071286	biological_process	cellular response to magnesium ion
D	0071320	biological_process	cellular response to cAMP
D	0071466	biological_process	cellular response to xenobiotic stimulus
D	0071475	biological_process	cellular hyperosmotic salinity response
D	0071477	biological_process	cellular hypotonic salinity response
D	0097403	biological_process	cellular response to raffinose
D	1904628	biological_process	cellular response to phorbol 13-acetate 12-myristate
E	0000122	biological_process	negative regulation of transcription by RNA polymerase II
E	0003824	molecular_function	catalytic activity
E	0005515	molecular_function	protein binding
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005975	biological_process	carbohydrate metabolic process
E	0005986	biological_process	sucrose biosynthetic process
E	0006000	biological_process	fructose metabolic process
E	0006002	biological_process	fructose 6-phosphate metabolic process
E	0006094	biological_process	gluconeogenesis
E	0006111	biological_process	regulation of gluconeogenesis
E	0008152	biological_process	metabolic process
E	0016208	molecular_function	AMP binding
E	0016311	biological_process	dephosphorylation
E	0016787	molecular_function	hydrolase activity
E	0016791	molecular_function	phosphatase activity
E	0030308	biological_process	negative regulation of cell growth
E	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
E	0031667	biological_process	response to nutrient levels
E	0032869	biological_process	cellular response to insulin stimulus
E	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
E	0042578	molecular_function	phosphoric ester hydrolase activity
E	0042802	molecular_function	identical protein binding
E	0045820	biological_process	negative regulation of glycolytic process
E	0046580	biological_process	negative regulation of Ras protein signal transduction
E	0046872	molecular_function	metal ion binding
E	0048029	molecular_function	monosaccharide binding
E	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
E	0070062	cellular_component	extracellular exosome
E	0071286	biological_process	cellular response to magnesium ion
E	0071320	biological_process	cellular response to cAMP
E	0071466	biological_process	cellular response to xenobiotic stimulus
E	0071475	biological_process	cellular hyperosmotic salinity response
E	0071477	biological_process	cellular hypotonic salinity response
E	0097403	biological_process	cellular response to raffinose
E	1904628	biological_process	cellular response to phorbol 13-acetate 12-myristate
F	0000122	biological_process	negative regulation of transcription by RNA polymerase II
F	0003824	molecular_function	catalytic activity
F	0005515	molecular_function	protein binding
F	0005615	cellular_component	extracellular space
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005975	biological_process	carbohydrate metabolic process
F	0005986	biological_process	sucrose biosynthetic process
F	0006000	biological_process	fructose metabolic process
F	0006002	biological_process	fructose 6-phosphate metabolic process
F	0006094	biological_process	gluconeogenesis
F	0006111	biological_process	regulation of gluconeogenesis
F	0008152	biological_process	metabolic process
F	0016208	molecular_function	AMP binding
F	0016311	biological_process	dephosphorylation
F	0016787	molecular_function	hydrolase activity
F	0016791	molecular_function	phosphatase activity
F	0030308	biological_process	negative regulation of cell growth
F	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
F	0031667	biological_process	response to nutrient levels
F	0032869	biological_process	cellular response to insulin stimulus
F	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
F	0042578	molecular_function	phosphoric ester hydrolase activity
F	0042802	molecular_function	identical protein binding
F	0045820	biological_process	negative regulation of glycolytic process
F	0046580	biological_process	negative regulation of Ras protein signal transduction
F	0046872	molecular_function	metal ion binding
F	0048029	molecular_function	monosaccharide binding
F	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
F	0070062	cellular_component	extracellular exosome
F	0071286	biological_process	cellular response to magnesium ion
F	0071320	biological_process	cellular response to cAMP
F	0071466	biological_process	cellular response to xenobiotic stimulus
F	0071475	biological_process	cellular hyperosmotic salinity response
F	0071477	biological_process	cellular hypotonic salinity response
F	0097403	biological_process	cellular response to raffinose
F	1904628	biological_process	cellular response to phorbol 13-acetate 12-myristate

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue ZN A 401

Chain	Residue
A	GLU98
A	ASP119
A	ASP122
A	GLU281
A	HOH501

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 402

Chain	Residue
A	GLU226
A	HIS335
A	HOH570
B	HIS335

site_id	AC3
Number of Residues	5
Details	binding site for residue SO4 A 403

Chain	Residue
A	ASP122
A	GLY123
A	SER124
A	SER125
A	HOH501

site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 A 404

Chain	Residue
A	LYS275
A	ARG277
A	ARG314

site_id	AC5
Number of Residues	6
Details	binding site for residue SO4 A 405

Chain	Residue
A	ASN213
A	TYR245
A	TYR265
A	HOH559
B	ARG244
B	SO4408

site_id	AC6
Number of Residues	7
Details	binding site for residue SO4 A 406

Chain	Residue
A	THR28
A	GLY29
A	GLU30
A	LEU31
A	LYS113
A	TYR114
A	HOH555

site_id	AC7
Number of Residues	5
Details	binding site for residue ZN B 401

Chain	Residue
B	GLU98
B	ASP119
B	ASP122
B	GLU281
B	HOH505

site_id	AC8
Number of Residues	5
Details	binding site for residue SO4 B 402

Chain	Residue
B	ASP122
B	GLY123
B	SER124
B	SER125
B	HOH505

site_id	AC9
Number of Residues	3
Details	binding site for residue SO4 B 403

Chain	Residue
B	LYS275
B	ARG277
B	ARG314

site_id	AD1
Number of Residues	6
Details	binding site for residue SO4 B 404

Chain	Residue
A	ARG244
B	ASN213
B	TYR245
B	TYR265
B	LYS275
B	HOH540

site_id	AD2
Number of Residues	8
Details	binding site for residue SO4 B 405

Chain	Residue
B	GLY27
B	THR28
B	GLY29
B	GLU30
B	LEU31
B	LYS113
B	TYR114
B	HOH560

site_id	AD3
Number of Residues	2
Details	binding site for residue SO4 B 406

Chain	Residue
B	ARG277
B	ARG314

site_id	AD4
Number of Residues	5
Details	binding site for residue SO4 B 407

Chain	Residue
B	LYS142
B	LYS143
B	SER144
B	THR145
B	ASP152

site_id	AD5
Number of Residues	5
Details	binding site for residue SO4 B 408

Chain	Residue
A	ASN213
A	TYR216
A	SO4405
B	GLY242
B	ARG244

site_id	AD6
Number of Residues	1
Details	binding site for residue CL B 409

Chain	Residue
B	LYS205

site_id	AD7
Number of Residues	5
Details	binding site for residue ZN C 401

Chain	Residue
C	GLU98
C	ASP119
C	ASP122
C	GLU281
C	HOH504

site_id	AD8
Number of Residues	5
Details	binding site for residue SO4 C 402

Chain	Residue
C	ASP122
C	GLY123
C	SER124
C	SER125
C	HOH504

site_id	AD9
Number of Residues	4
Details	binding site for residue SO4 C 403

Chain	Residue
C	LYS275
C	ARG277
C	ARG314
C	HOH511

site_id	AE1
Number of Residues	7
Details	binding site for residue SO4 C 404

Chain	Residue
C	ASN213
C	TYR216
C	TYR245
C	TYR265
C	LYS275
C	HOH514
D	ARG244

site_id	AE2
Number of Residues	6
Details	binding site for residue SO4 C 405

Chain	Residue
C	THR28
C	GLY29
C	GLU30
C	LEU31
C	LYS113
C	TYR114

site_id	AE3
Number of Residues	2
Details	binding site for residue SO4 C 406

Chain	Residue
C	ARG277
C	ARG314

site_id	AE4
Number of Residues	5
Details	binding site for residue ZN D 401

Chain	Residue
D	GLU98
D	ASP119
D	ASP122
D	GLU281
D	HOH502

site_id	AE5
Number of Residues	4
Details	binding site for residue ZN D 402

Chain	Residue
D	GLU226
D	HIS335
D	HOH578
F	HIS335

site_id	AE6
Number of Residues	6
Details	binding site for residue SO4 D 403

Chain	Residue
D	ASP122
D	GLY123
D	SER124
D	SER125
D	HOH502
D	HOH515

site_id	AE7
Number of Residues	3
Details	binding site for residue SO4 D 404

Chain	Residue
D	LYS275
D	ARG277
D	ARG314

site_id	AE8
Number of Residues	5
Details	binding site for residue SO4 D 405

Chain	Residue
C	ARG244
D	ASN213
D	TYR245
D	TYR265
D	HOH513

site_id	AE9
Number of Residues	7
Details	binding site for residue SO4 D 406

Chain	Residue
D	GLY27
D	THR28
D	GLY29
D	GLU30
D	LEU31
D	TYR114
D	HOH521

site_id	AF1
Number of Residues	2
Details	binding site for residue CL D 407

Chain	Residue
D	LYS205
D	HOH573

site_id	AF2
Number of Residues	5
Details	binding site for residue ZN E 401

Chain	Residue
E	GLU98
E	ASP119
E	ASP122
E	GLU281
E	HOH501

site_id	AF3
Number of Residues	5
Details	binding site for residue ZN E 402

Chain	Residue
C	PRO222
C	HIS335
E	GLU226
E	HIS335
E	HOH577

site_id	AF4
Number of Residues	6
Details	binding site for residue SO4 E 403

Chain	Residue
E	ASP122
E	GLY123
E	SER124
E	SER125
E	HOH501
E	HOH525

site_id	AF5
Number of Residues	3
Details	binding site for residue SO4 E 404

Chain	Residue
E	LYS275
E	ARG277
E	ARG314

site_id	AF6
Number of Residues	7
Details	binding site for residue SO4 E 405

Chain	Residue
E	ASN213
E	TYR216
E	TYR245
E	TYR265
E	LYS275
F	ARG244
F	HOH543

site_id	AF7
Number of Residues	6
Details	binding site for residue SO4 E 406

Chain	Residue
E	THR28
E	GLY29
E	GLU30
E	LEU31
E	LYS113
E	TYR114

site_id	AF8
Number of Residues	5
Details	binding site for residue ZN F 401

Chain	Residue
F	GLU98
F	ASP119
F	ASP122
F	GLU281
F	HOH502

site_id	AF9
Number of Residues	5
Details	binding site for residue SO4 F 402

Chain	Residue
F	ASP122
F	GLY123
F	SER124
F	SER125
F	HOH502

site_id	AG1
Number of Residues	3
Details	binding site for residue SO4 F 403

Chain	Residue
F	LYS275
F	ARG277
F	ARG314

site_id	AG2
Number of Residues	6
Details	binding site for residue SO4 F 404

Chain	Residue
E	ARG244
F	ASN213
F	TYR216
F	TYR245
F	TYR265
F	HOH521

site_id	AG3
Number of Residues	8
Details	binding site for residue SO4 F 405

Chain	Residue
F	GLY27
F	THR28
F	GLY29
F	GLU30
F	LEU31
F	LYS113
F	TYR114
F	HOH534

site_id	AG4
Number of Residues	2
Details	binding site for residue SO4 F 406

Chain	Residue
F	ARG277
F	ARG314

site_id	AG5
Number of Residues	1
Details	binding site for residue CL F 407

Chain	Residue
F	LYS205

Functional Information from PROSITE/UniProt

site_id	PS00124
Number of Residues	13
Details	FBPASE Fructose-1-6-bisphosphatase active site. GKLrlLYEcnPMA

Chain	Residue	Details
A	GLY274-ALA286

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269\|PubMed:7809062, ECO:0007744\|PDB:1FTA

Chain	Residue	Details
A	VAL18
C	THR28
C	LYS113
C	ARG141
D	VAL18
D	THR28
D	LYS113
D	ARG141
E	VAL18
E	THR28
E	LYS113
A	THR28
E	ARG141
F	VAL18
F	THR28
F	LYS113
F	ARG141
A	LYS113
A	ARG141
B	VAL18
B	THR28
B	LYS113
B	ARG141
C	VAL18

site_id	SWS_FT_FI2
Number of Residues	42
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P00636

Chain	Residue	Details
A	ASP69
B	LEU121
B	ASN213
B	ARG244
B	TYR265
B	LYS275
C	ASP69
C	GLU98
C	LEU121
C	ASN213
C	ARG244
A	GLU98
C	TYR265
C	LYS275
D	ASP69
D	GLU98
D	LEU121
D	ASN213
D	ARG244
D	TYR265
D	LYS275
E	ASP69
A	LEU121
E	GLU98
E	LEU121
E	ASN213
E	ARG244
E	TYR265
E	LYS275
F	ASP69
F	GLU98
F	LEU121
F	ASN213
A	ASN213
F	ARG244
F	TYR265
F	LYS275
A	ARG244
A	TYR265
A	LYS275
B	ASP69
B	GLU98

site_id	SWS_FT_FI3
Number of Residues	18
Details	BINDING: BINDING => ECO:0007744\|PDB:2FHY

Chain	Residue	Details
A	ASP119
D	ASP119
D	ASP122
D	GLU281
E	ASP119
E	ASP122
E	GLU281
F	ASP119
F	ASP122
F	GLU281
A	ASP122
A	GLU281
B	ASP119
B	ASP122
B	GLU281
C	ASP119
C	ASP122
C	GLU281

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: N-acetylalanine => ECO:0000250\|UniProtKB:P00637

Chain	Residue	Details
A	ALA2
B	ALA2
C	ALA2
D	ALA2
E	ALA2
F	ALA2

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:Q9QXD6

Chain	Residue	Details
A	LYS151
B	LYS151
C	LYS151
D	LYS151
E	LYS151
F	LYS151

site_id	SWS_FT_FI6
Number of Residues	12
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:Q9QXD6

Chain	Residue	Details
A	TYR216
E	TYR245
F	TYR216
F	TYR245
A	TYR245
B	TYR216
B	TYR245
C	TYR216
C	TYR245
D	TYR216
D	TYR245
E	TYR216

site_id	SWS_FT_FI7
Number of Residues	6
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	TYR265
B	TYR265
C	TYR265
D	TYR265
E	TYR265
F	TYR265

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)