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5L8Y

Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-937

Functional Information from GO Data
ChainGOidnamespacecontents
A0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
A0007165biological_processsignal transduction
A0008081molecular_functionphosphoric diester hydrolase activity
B0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
B0007165biological_processsignal transduction
B0008081molecular_functionphosphoric diester hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue ZN A 1001
ChainResidue
AHIS673
AHIS709
AASP710
AASP822
AHOH1122
AHOH1163

site_idAC2
Number of Residues6
Detailsbinding site for residue MG A 1002
ChainResidue
AHOH1166
AHOH1177
AHOH1183
AASP710
AHOH1107
AHOH1122

site_idAC3
Number of Residues2
Detailsbinding site for residue FMT A 1003
ChainResidue
APHE645
AGLU768

site_idAC4
Number of Residues5
Detailsbinding site for residue GAI A 1004
ChainResidue
ASER754
AASP759
AASP762
ALEU915
AHOH1138

site_idAC5
Number of Residues6
Detailsbinding site for residue ZN B 1001
ChainResidue
BHIS673
BHIS709
BASP710
BASP822
BHOH1116
BHOH1169

site_idAC6
Number of Residues6
Detailsbinding site for residue MG B 1002
ChainResidue
BASP710
BHOH1116
BHOH1130
BHOH1153
BHOH1159
BHOH1223

site_idAC7
Number of Residues7
Detailsbinding site for residue GOL B 1003
ChainResidue
ATYR691
ALEU694
AGLU696
BTYR691
BLEU694
BHOH1143
BHOH1162

site_idAC8
Number of Residues16
Detailsbinding site for residue CVA B 1004
ChainResidue
BMET785
BASP822
BILE823
BTHR841
BPHE844
BTYR845
BMET861
BASN867
BMET868
BGLU869
BLEU870
BGLY873
BGLN874
BHOH1147
BHOH1205
BHOH1212

Functional Information from PROSITE/UniProt
site_idPS00126
Number of Residues12
DetailsPDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHmGlnNsF
ChainResidueDetails
AHIS709-PHE720

221051

PDB entries from 2024-06-12

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