5KO9

Crystal Structure of the SRAP Domain of Human HMCES Protein

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003697	molecular_function	single-stranded DNA binding
A	0006974	biological_process	DNA damage response
A	0106300	biological_process	protein-DNA covalent cross-linking repair

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:31235913, ECO:0000305|PubMed:30554877

Chain	Residue	Details
A	CYS2

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000269|PubMed:37519246, ECO:0000269|PubMed:37950866

Chain	Residue	Details
A	GLU127

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Required for sensing abasic sites => ECO:0000250|UniProtKB:P76318

Chain	Residue	Details
A	GLU127

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site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Required to stabilize abasic sites => ECO:0000250|UniProtKB:P76318

Chain	Residue	Details
A	HIS210

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Thiazolidine linkage to a ring-opened DNA abasic site => ECO:0000269|PubMed:31235913

Chain	Residue	Details
A	CYS2

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER160

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site_id	SWS_FT_FI7
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS148
A	LYS151

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