5JCO

Structure and dynamics of single-isoform recombinant neuronal human tubulin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0000793	cellular_component	condensed chromosome
A	0001764	biological_process	neuron migration
A	0001964	biological_process	startle response
A	0005198	molecular_function	structural molecule activity
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005879	cellular_component	axonemal microtubule
A	0005881	cellular_component	cytoplasmic microtubule
A	0005886	cellular_component	plasma membrane
A	0006886	biological_process	intracellular protein transport
A	0007017	biological_process	microtubule-based process
A	0007098	biological_process	centrosome cycle
A	0007224	biological_process	smoothened signaling pathway
A	0007613	biological_process	memory
A	0007626	biological_process	locomotory behavior
A	0008344	biological_process	adult locomotory behavior
A	0008542	biological_process	visual learning
A	0009612	biological_process	response to mechanical stimulus
A	0010001	biological_process	glial cell differentiation
A	0010467	biological_process	gene expression
A	0015630	cellular_component	microtubule cytoskeleton
A	0016787	molecular_function	hydrolase activity
A	0021542	biological_process	dentate gyrus development
A	0021696	biological_process	cerebellar cortex morphogenesis
A	0021766	biological_process	hippocampus development
A	0021859	biological_process	pyramidal neuron differentiation
A	0021987	biological_process	cerebral cortex development
A	0022008	biological_process	neurogenesis
A	0030182	biological_process	neuron differentiation
A	0030534	biological_process	adult behavior
A	0030705	biological_process	cytoskeleton-dependent intracellular transport
A	0031594	cellular_component	neuromuscular junction
A	0034612	biological_process	response to tumor necrosis factor
A	0035641	biological_process	locomotory exploration behavior
A	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
A	0042802	molecular_function	identical protein binding
A	0044877	molecular_function	protein-containing complex binding
A	0045202	cellular_component	synapse
A	0046785	biological_process	microtubule polymerization
A	0046872	molecular_function	metal ion binding
A	0046982	molecular_function	protein heterodimerization activity
A	0048853	biological_process	forebrain morphogenesis
A	0048873	biological_process	homeostasis of number of cells within a tissue
A	0050807	biological_process	regulation of synapse organization
A	0050808	biological_process	synapse organization
A	0051301	biological_process	cell division
A	0051402	biological_process	neuron apoptotic process
A	0055037	cellular_component	recycling endosome
A	0061744	biological_process	motor behavior
A	0070062	cellular_component	extracellular exosome
A	0071277	biological_process	cellular response to calcium ion
A	0072384	biological_process	organelle transport along microtubule
A	0140058	biological_process	neuron projection arborization
A	1902065	biological_process	response to L-glutamate
B	0000166	molecular_function	nucleotide binding
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000278	biological_process	mitotic cell cycle
B	0000793	cellular_component	condensed chromosome
B	0001764	biological_process	neuron migration
B	0001964	biological_process	startle response
B	0005198	molecular_function	structural molecule activity
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0005879	cellular_component	axonemal microtubule
B	0005881	cellular_component	cytoplasmic microtubule
B	0005886	cellular_component	plasma membrane
B	0006886	biological_process	intracellular protein transport
B	0007017	biological_process	microtubule-based process
B	0007098	biological_process	centrosome cycle
B	0007224	biological_process	smoothened signaling pathway
B	0007613	biological_process	memory
B	0007626	biological_process	locomotory behavior
B	0008344	biological_process	adult locomotory behavior
B	0008542	biological_process	visual learning
B	0009612	biological_process	response to mechanical stimulus
B	0010001	biological_process	glial cell differentiation
B	0010467	biological_process	gene expression
B	0015630	cellular_component	microtubule cytoskeleton
B	0016787	molecular_function	hydrolase activity
B	0021542	biological_process	dentate gyrus development
B	0021696	biological_process	cerebellar cortex morphogenesis
B	0021766	biological_process	hippocampus development
B	0021859	biological_process	pyramidal neuron differentiation
B	0021987	biological_process	cerebral cortex development
B	0022008	biological_process	neurogenesis
B	0030182	biological_process	neuron differentiation
B	0030534	biological_process	adult behavior
B	0030705	biological_process	cytoskeleton-dependent intracellular transport
B	0031594	cellular_component	neuromuscular junction
B	0034612	biological_process	response to tumor necrosis factor
B	0035641	biological_process	locomotory exploration behavior
B	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
B	0042802	molecular_function	identical protein binding
B	0044877	molecular_function	protein-containing complex binding
B	0045202	cellular_component	synapse
B	0046785	biological_process	microtubule polymerization
B	0046872	molecular_function	metal ion binding
B	0046982	molecular_function	protein heterodimerization activity
B	0048853	biological_process	forebrain morphogenesis
B	0048873	biological_process	homeostasis of number of cells within a tissue
B	0050807	biological_process	regulation of synapse organization
B	0050808	biological_process	synapse organization
B	0051301	biological_process	cell division
B	0051402	biological_process	neuron apoptotic process
B	0055037	cellular_component	recycling endosome
B	0061744	biological_process	motor behavior
B	0070062	cellular_component	extracellular exosome
B	0071277	biological_process	cellular response to calcium ion
B	0072384	biological_process	organelle transport along microtubule
B	0140058	biological_process	neuron projection arborization
B	1902065	biological_process	response to L-glutamate
C	0000166	molecular_function	nucleotide binding
C	0000226	biological_process	microtubule cytoskeleton organization
C	0000278	biological_process	mitotic cell cycle
C	0003924	molecular_function	GTPase activity
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0007017	biological_process	microtubule-based process
C	0007411	biological_process	axon guidance
C	0015630	cellular_component	microtubule cytoskeleton
C	0030027	cellular_component	lamellipodium
C	0030175	cellular_component	filopodium
C	0030182	biological_process	neuron differentiation
C	0030424	cellular_component	axon
C	0030425	cellular_component	dendrite
C	0030426	cellular_component	growth cone
C	0038007	biological_process	netrin-activated signaling pathway
C	0042277	molecular_function	peptide binding
C	0042995	cellular_component	cell projection
C	0043025	cellular_component	neuronal cell body
C	0045171	cellular_component	intercellular bridge
C	0046872	molecular_function	metal ion binding
C	0070062	cellular_component	extracellular exosome
C	0071944	cellular_component	cell periphery
C	0072686	cellular_component	mitotic spindle
C	1990791	biological_process	dorsal root ganglion development
C	1990890	molecular_function	netrin receptor binding
D	0000166	molecular_function	nucleotide binding
D	0000226	biological_process	microtubule cytoskeleton organization
D	0000278	biological_process	mitotic cell cycle
D	0003924	molecular_function	GTPase activity
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005874	cellular_component	microtubule
D	0007017	biological_process	microtubule-based process
D	0007411	biological_process	axon guidance
D	0015630	cellular_component	microtubule cytoskeleton
D	0030027	cellular_component	lamellipodium
D	0030175	cellular_component	filopodium
D	0030182	biological_process	neuron differentiation
D	0030424	cellular_component	axon
D	0030425	cellular_component	dendrite
D	0030426	cellular_component	growth cone
D	0038007	biological_process	netrin-activated signaling pathway
D	0042277	molecular_function	peptide binding
D	0042995	cellular_component	cell projection
D	0043025	cellular_component	neuronal cell body
D	0045171	cellular_component	intercellular bridge
D	0046872	molecular_function	metal ion binding
D	0070062	cellular_component	extracellular exosome
D	0071944	cellular_component	cell periphery
D	0072686	cellular_component	mitotic spindle
D	1990791	biological_process	dorsal root ganglion development
D	1990890	molecular_function	netrin receptor binding
E	0000166	molecular_function	nucleotide binding
E	0000226	biological_process	microtubule cytoskeleton organization
E	0000278	biological_process	mitotic cell cycle
E	0000793	cellular_component	condensed chromosome
E	0001764	biological_process	neuron migration
E	0001964	biological_process	startle response
E	0005198	molecular_function	structural molecule activity
E	0005200	molecular_function	structural constituent of cytoskeleton
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005874	cellular_component	microtubule
E	0005879	cellular_component	axonemal microtubule
E	0005881	cellular_component	cytoplasmic microtubule
E	0005886	cellular_component	plasma membrane
E	0006886	biological_process	intracellular protein transport
E	0007017	biological_process	microtubule-based process
E	0007098	biological_process	centrosome cycle
E	0007224	biological_process	smoothened signaling pathway
E	0007613	biological_process	memory
E	0007626	biological_process	locomotory behavior
E	0008344	biological_process	adult locomotory behavior
E	0008542	biological_process	visual learning
E	0009612	biological_process	response to mechanical stimulus
E	0010001	biological_process	glial cell differentiation
E	0010467	biological_process	gene expression
E	0015630	cellular_component	microtubule cytoskeleton
E	0016787	molecular_function	hydrolase activity
E	0021542	biological_process	dentate gyrus development
E	0021696	biological_process	cerebellar cortex morphogenesis
E	0021766	biological_process	hippocampus development
E	0021859	biological_process	pyramidal neuron differentiation
E	0021987	biological_process	cerebral cortex development
E	0022008	biological_process	neurogenesis
E	0030182	biological_process	neuron differentiation
E	0030534	biological_process	adult behavior
E	0030705	biological_process	cytoskeleton-dependent intracellular transport
E	0031594	cellular_component	neuromuscular junction
E	0034612	biological_process	response to tumor necrosis factor
E	0035641	biological_process	locomotory exploration behavior
E	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
E	0042802	molecular_function	identical protein binding
E	0044877	molecular_function	protein-containing complex binding
E	0045202	cellular_component	synapse
E	0046785	biological_process	microtubule polymerization
E	0046872	molecular_function	metal ion binding
E	0046982	molecular_function	protein heterodimerization activity
E	0048853	biological_process	forebrain morphogenesis
E	0048873	biological_process	homeostasis of number of cells within a tissue
E	0050807	biological_process	regulation of synapse organization
E	0050808	biological_process	synapse organization
E	0051301	biological_process	cell division
E	0051402	biological_process	neuron apoptotic process
E	0055037	cellular_component	recycling endosome
E	0061744	biological_process	motor behavior
E	0070062	cellular_component	extracellular exosome
E	0071277	biological_process	cellular response to calcium ion
E	0072384	biological_process	organelle transport along microtubule
E	0140058	biological_process	neuron projection arborization
E	1902065	biological_process	response to L-glutamate
F	0000166	molecular_function	nucleotide binding
F	0000226	biological_process	microtubule cytoskeleton organization
F	0000278	biological_process	mitotic cell cycle
F	0000793	cellular_component	condensed chromosome
F	0001764	biological_process	neuron migration
F	0001964	biological_process	startle response
F	0005198	molecular_function	structural molecule activity
F	0005200	molecular_function	structural constituent of cytoskeleton
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005874	cellular_component	microtubule
F	0005879	cellular_component	axonemal microtubule
F	0005881	cellular_component	cytoplasmic microtubule
F	0005886	cellular_component	plasma membrane
F	0006886	biological_process	intracellular protein transport
F	0007017	biological_process	microtubule-based process
F	0007098	biological_process	centrosome cycle
F	0007224	biological_process	smoothened signaling pathway
F	0007613	biological_process	memory
F	0007626	biological_process	locomotory behavior
F	0008344	biological_process	adult locomotory behavior
F	0008542	biological_process	visual learning
F	0009612	biological_process	response to mechanical stimulus
F	0010001	biological_process	glial cell differentiation
F	0010467	biological_process	gene expression
F	0015630	cellular_component	microtubule cytoskeleton
F	0016787	molecular_function	hydrolase activity
F	0021542	biological_process	dentate gyrus development
F	0021696	biological_process	cerebellar cortex morphogenesis
F	0021766	biological_process	hippocampus development
F	0021859	biological_process	pyramidal neuron differentiation
F	0021987	biological_process	cerebral cortex development
F	0022008	biological_process	neurogenesis
F	0030182	biological_process	neuron differentiation
F	0030534	biological_process	adult behavior
F	0030705	biological_process	cytoskeleton-dependent intracellular transport
F	0031594	cellular_component	neuromuscular junction
F	0034612	biological_process	response to tumor necrosis factor
F	0035641	biological_process	locomotory exploration behavior
F	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
F	0042802	molecular_function	identical protein binding
F	0044877	molecular_function	protein-containing complex binding
F	0045202	cellular_component	synapse
F	0046785	biological_process	microtubule polymerization
F	0046872	molecular_function	metal ion binding
F	0046982	molecular_function	protein heterodimerization activity
F	0048853	biological_process	forebrain morphogenesis
F	0048873	biological_process	homeostasis of number of cells within a tissue
F	0050807	biological_process	regulation of synapse organization
F	0050808	biological_process	synapse organization
F	0051301	biological_process	cell division
F	0051402	biological_process	neuron apoptotic process
F	0055037	cellular_component	recycling endosome
F	0061744	biological_process	motor behavior
F	0070062	cellular_component	extracellular exosome
F	0071277	biological_process	cellular response to calcium ion
F	0072384	biological_process	organelle transport along microtubule
F	0140058	biological_process	neuron projection arborization
F	1902065	biological_process	response to L-glutamate
G	0000166	molecular_function	nucleotide binding
G	0000226	biological_process	microtubule cytoskeleton organization
G	0000278	biological_process	mitotic cell cycle
G	0000793	cellular_component	condensed chromosome
G	0001764	biological_process	neuron migration
G	0001964	biological_process	startle response
G	0005198	molecular_function	structural molecule activity
G	0005200	molecular_function	structural constituent of cytoskeleton
G	0005515	molecular_function	protein binding
G	0005525	molecular_function	GTP binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005874	cellular_component	microtubule
G	0005879	cellular_component	axonemal microtubule
G	0005881	cellular_component	cytoplasmic microtubule
G	0005886	cellular_component	plasma membrane
G	0006886	biological_process	intracellular protein transport
G	0007017	biological_process	microtubule-based process
G	0007098	biological_process	centrosome cycle
G	0007224	biological_process	smoothened signaling pathway
G	0007613	biological_process	memory
G	0007626	biological_process	locomotory behavior
G	0008344	biological_process	adult locomotory behavior
G	0008542	biological_process	visual learning
G	0009612	biological_process	response to mechanical stimulus
G	0010001	biological_process	glial cell differentiation
G	0010467	biological_process	gene expression
G	0015630	cellular_component	microtubule cytoskeleton
G	0016787	molecular_function	hydrolase activity
G	0021542	biological_process	dentate gyrus development
G	0021696	biological_process	cerebellar cortex morphogenesis
G	0021766	biological_process	hippocampus development
G	0021859	biological_process	pyramidal neuron differentiation
G	0021987	biological_process	cerebral cortex development
G	0022008	biological_process	neurogenesis
G	0030182	biological_process	neuron differentiation
G	0030534	biological_process	adult behavior
G	0030705	biological_process	cytoskeleton-dependent intracellular transport
G	0031594	cellular_component	neuromuscular junction
G	0034612	biological_process	response to tumor necrosis factor
G	0035641	biological_process	locomotory exploration behavior
G	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
G	0042802	molecular_function	identical protein binding
G	0044877	molecular_function	protein-containing complex binding
G	0045202	cellular_component	synapse
G	0046785	biological_process	microtubule polymerization
G	0046872	molecular_function	metal ion binding
G	0046982	molecular_function	protein heterodimerization activity
G	0048853	biological_process	forebrain morphogenesis
G	0048873	biological_process	homeostasis of number of cells within a tissue
G	0050807	biological_process	regulation of synapse organization
G	0050808	biological_process	synapse organization
G	0051301	biological_process	cell division
G	0051402	biological_process	neuron apoptotic process
G	0055037	cellular_component	recycling endosome
G	0061744	biological_process	motor behavior
G	0070062	cellular_component	extracellular exosome
G	0071277	biological_process	cellular response to calcium ion
G	0072384	biological_process	organelle transport along microtubule
G	0140058	biological_process	neuron projection arborization
G	1902065	biological_process	response to L-glutamate
H	0000166	molecular_function	nucleotide binding
H	0000226	biological_process	microtubule cytoskeleton organization
H	0000278	biological_process	mitotic cell cycle
H	0000793	cellular_component	condensed chromosome
H	0001764	biological_process	neuron migration
H	0001964	biological_process	startle response
H	0005198	molecular_function	structural molecule activity
H	0005200	molecular_function	structural constituent of cytoskeleton
H	0005515	molecular_function	protein binding
H	0005525	molecular_function	GTP binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0005874	cellular_component	microtubule
H	0005879	cellular_component	axonemal microtubule
H	0005881	cellular_component	cytoplasmic microtubule
H	0005886	cellular_component	plasma membrane
H	0006886	biological_process	intracellular protein transport
H	0007017	biological_process	microtubule-based process
H	0007098	biological_process	centrosome cycle
H	0007224	biological_process	smoothened signaling pathway
H	0007613	biological_process	memory
H	0007626	biological_process	locomotory behavior
H	0008344	biological_process	adult locomotory behavior
H	0008542	biological_process	visual learning
H	0009612	biological_process	response to mechanical stimulus
H	0010001	biological_process	glial cell differentiation
H	0010467	biological_process	gene expression
H	0015630	cellular_component	microtubule cytoskeleton
H	0016787	molecular_function	hydrolase activity
H	0021542	biological_process	dentate gyrus development
H	0021696	biological_process	cerebellar cortex morphogenesis
H	0021766	biological_process	hippocampus development
H	0021859	biological_process	pyramidal neuron differentiation
H	0021987	biological_process	cerebral cortex development
H	0022008	biological_process	neurogenesis
H	0030182	biological_process	neuron differentiation
H	0030534	biological_process	adult behavior
H	0030705	biological_process	cytoskeleton-dependent intracellular transport
H	0031594	cellular_component	neuromuscular junction
H	0034612	biological_process	response to tumor necrosis factor
H	0035641	biological_process	locomotory exploration behavior
H	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
H	0042802	molecular_function	identical protein binding
H	0044877	molecular_function	protein-containing complex binding
H	0045202	cellular_component	synapse
H	0046785	biological_process	microtubule polymerization
H	0046872	molecular_function	metal ion binding
H	0046982	molecular_function	protein heterodimerization activity
H	0048853	biological_process	forebrain morphogenesis
H	0048873	biological_process	homeostasis of number of cells within a tissue
H	0050807	biological_process	regulation of synapse organization
H	0050808	biological_process	synapse organization
H	0051301	biological_process	cell division
H	0051402	biological_process	neuron apoptotic process
H	0055037	cellular_component	recycling endosome
H	0061744	biological_process	motor behavior
H	0070062	cellular_component	extracellular exosome
H	0071277	biological_process	cellular response to calcium ion
H	0072384	biological_process	organelle transport along microtubule
H	0140058	biological_process	neuron projection arborization
H	1902065	biological_process	response to L-glutamate
I	0000166	molecular_function	nucleotide binding
I	0000226	biological_process	microtubule cytoskeleton organization
I	0000278	biological_process	mitotic cell cycle
I	0003924	molecular_function	GTPase activity
I	0005200	molecular_function	structural constituent of cytoskeleton
I	0005515	molecular_function	protein binding
I	0005525	molecular_function	GTP binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005856	cellular_component	cytoskeleton
I	0005874	cellular_component	microtubule
I	0007017	biological_process	microtubule-based process
I	0007411	biological_process	axon guidance
I	0015630	cellular_component	microtubule cytoskeleton
I	0030027	cellular_component	lamellipodium
I	0030175	cellular_component	filopodium
I	0030182	biological_process	neuron differentiation
I	0030424	cellular_component	axon
I	0030425	cellular_component	dendrite
I	0030426	cellular_component	growth cone
I	0038007	biological_process	netrin-activated signaling pathway
I	0042277	molecular_function	peptide binding
I	0042995	cellular_component	cell projection
I	0043025	cellular_component	neuronal cell body
I	0045171	cellular_component	intercellular bridge
I	0046872	molecular_function	metal ion binding
I	0070062	cellular_component	extracellular exosome
I	0071944	cellular_component	cell periphery
I	0072686	cellular_component	mitotic spindle
I	1990791	biological_process	dorsal root ganglion development
I	1990890	molecular_function	netrin receptor binding
J	0000166	molecular_function	nucleotide binding
J	0000226	biological_process	microtubule cytoskeleton organization
J	0000278	biological_process	mitotic cell cycle
J	0003924	molecular_function	GTPase activity
J	0005200	molecular_function	structural constituent of cytoskeleton
J	0005515	molecular_function	protein binding
J	0005525	molecular_function	GTP binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005856	cellular_component	cytoskeleton
J	0005874	cellular_component	microtubule
J	0007017	biological_process	microtubule-based process
J	0007411	biological_process	axon guidance
J	0015630	cellular_component	microtubule cytoskeleton
J	0030027	cellular_component	lamellipodium
J	0030175	cellular_component	filopodium
J	0030182	biological_process	neuron differentiation
J	0030424	cellular_component	axon
J	0030425	cellular_component	dendrite
J	0030426	cellular_component	growth cone
J	0038007	biological_process	netrin-activated signaling pathway
J	0042277	molecular_function	peptide binding
J	0042995	cellular_component	cell projection
J	0043025	cellular_component	neuronal cell body
J	0045171	cellular_component	intercellular bridge
J	0046872	molecular_function	metal ion binding
J	0070062	cellular_component	extracellular exosome
J	0071944	cellular_component	cell periphery
J	0072686	cellular_component	mitotic spindle
J	1990791	biological_process	dorsal root ganglion development
J	1990890	molecular_function	netrin receptor binding
K	0000166	molecular_function	nucleotide binding
K	0000226	biological_process	microtubule cytoskeleton organization
K	0000278	biological_process	mitotic cell cycle
K	0003924	molecular_function	GTPase activity
K	0005200	molecular_function	structural constituent of cytoskeleton
K	0005515	molecular_function	protein binding
K	0005525	molecular_function	GTP binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005856	cellular_component	cytoskeleton
K	0005874	cellular_component	microtubule
K	0007017	biological_process	microtubule-based process
K	0007411	biological_process	axon guidance
K	0015630	cellular_component	microtubule cytoskeleton
K	0030027	cellular_component	lamellipodium
K	0030175	cellular_component	filopodium
K	0030182	biological_process	neuron differentiation
K	0030424	cellular_component	axon
K	0030425	cellular_component	dendrite
K	0030426	cellular_component	growth cone
K	0038007	biological_process	netrin-activated signaling pathway
K	0042277	molecular_function	peptide binding
K	0042995	cellular_component	cell projection
K	0043025	cellular_component	neuronal cell body
K	0045171	cellular_component	intercellular bridge
K	0046872	molecular_function	metal ion binding
K	0070062	cellular_component	extracellular exosome
K	0071944	cellular_component	cell periphery
K	0072686	cellular_component	mitotic spindle
K	1990791	biological_process	dorsal root ganglion development
K	1990890	molecular_function	netrin receptor binding
L	0000166	molecular_function	nucleotide binding
L	0000226	biological_process	microtubule cytoskeleton organization
L	0000278	biological_process	mitotic cell cycle
L	0003924	molecular_function	GTPase activity
L	0005200	molecular_function	structural constituent of cytoskeleton
L	0005515	molecular_function	protein binding
L	0005525	molecular_function	GTP binding
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005856	cellular_component	cytoskeleton
L	0005874	cellular_component	microtubule
L	0007017	biological_process	microtubule-based process
L	0007411	biological_process	axon guidance
L	0015630	cellular_component	microtubule cytoskeleton
L	0030027	cellular_component	lamellipodium
L	0030175	cellular_component	filopodium
L	0030182	biological_process	neuron differentiation
L	0030424	cellular_component	axon
L	0030425	cellular_component	dendrite
L	0030426	cellular_component	growth cone
L	0038007	biological_process	netrin-activated signaling pathway
L	0042277	molecular_function	peptide binding
L	0042995	cellular_component	cell projection
L	0043025	cellular_component	neuronal cell body
L	0045171	cellular_component	intercellular bridge
L	0046872	molecular_function	metal ion binding
L	0070062	cellular_component	extracellular exosome
L	0071944	cellular_component	cell periphery
L	0072686	cellular_component	mitotic spindle
L	1990791	biological_process	dorsal root ganglion development
L	1990890	molecular_function	netrin receptor binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue G2P K 501

Chain	Residue
K	GLY10
K	GLY142
K	THR143
K	GLY144
K	VAL169
K	ASP177
K	GLU181
K	ASN204
K	TYR222
K	ASN226
K	MG502
K	GLN11
K	CYS12
K	GLN15
K	ALA97
K	GLY98
K	ASN99
K	SER138
K	GLY141

---

site_id	AC2
Number of Residues	3
Details	binding site for residue MG K 502

Chain	Residue
K	GLN11
K	GLU69
K	G2P501

---

site_id	AC3
Number of Residues	19
Details	binding site for residue GTP H 501

Chain	Residue
D	LYS252
H	GLY10
H	GLN11
H	ALA12
H	GLN15
H	ASP98
H	ALA99
H	ASN101
H	SER140
H	GLY143
H	GLY144
H	THR145
H	GLY146
H	ILE171
H	GLU183
H	ASN206
H	TYR224
H	ASN228
H	MG502

---

site_id	AC4
Number of Residues	2
Details	binding site for residue MG H 502

Chain	Residue
H	GLN11
H	GTP501

---

site_id	AC5
Number of Residues	18
Details	binding site for residue G2P I 501

Chain	Residue
I	GLY10
I	GLN11
I	CYS12
I	GLN15
I	ALA97
I	GLY98
I	ASN99
I	SER138
I	GLY141
I	GLY142
I	THR143
I	GLY144
I	ASP177
I	GLU181
I	ASN204
I	TYR222
I	ASN226
I	MG502

---

site_id	AC6
Number of Residues	3
Details	binding site for residue MG I 502

Chain	Residue
I	GLN11
I	GLU69
I	G2P501

---

site_id	AC7
Number of Residues	19
Details	binding site for residue GTP E 501

Chain	Residue
C	LYS252
E	GLY10
E	GLN11
E	ALA12
E	GLN15
E	ASP98
E	ALA99
E	ASN101
E	SER140
E	GLY143
E	GLY144
E	THR145
E	GLY146
E	ILE171
E	GLU183
E	ASN206
E	TYR224
E	ASN228
E	MG502

---

site_id	AC8
Number of Residues	2
Details	binding site for residue MG E 502

Chain	Residue
E	GLN11
E	GTP501

---

site_id	AC9
Number of Residues	19
Details	binding site for residue G2P J 501

Chain	Residue
J	GLU181
J	ASN204
J	TYR222
J	ASN226
J	MG502
J	GLY10
J	GLN11
J	CYS12
J	GLN15
J	ALA97
J	GLY98
J	ASN99
J	SER138
J	GLY141
J	GLY142
J	THR143
J	GLY144
J	VAL169
J	ASP177

---

site_id	AD1
Number of Residues	3
Details	binding site for residue MG J 502

Chain	Residue
J	GLN11
J	GLU69
J	G2P501

---

site_id	AD2
Number of Residues	18
Details	binding site for residue G2P C 501

Chain	Residue
C	GLY10
C	GLN11
C	CYS12
C	GLN15
C	ALA97
C	GLY98
C	ASN99
C	SER138
C	GLY141
C	GLY142
C	THR143
C	GLY144
C	ASP177
C	GLU181
C	ASN204
C	TYR222
C	ASN226
C	MG502

---

site_id	AD3
Number of Residues	3
Details	binding site for residue MG C 502

Chain	Residue
C	GLN11
C	GLU69
C	G2P501

---

site_id	AD4
Number of Residues	19
Details	binding site for residue G2P D 501

Chain	Residue
D	GLY10
D	GLN11
D	CYS12
D	GLN15
D	ALA97
D	GLY98
D	ASN99
D	SER138
D	GLY141
D	GLY142
D	THR143
D	GLY144
D	VAL169
D	ASP177
D	GLU181
D	ASN204
D	TYR222
D	ASN226
D	MG502

---

site_id	AD5
Number of Residues	3
Details	binding site for residue MG D 502

Chain	Residue
D	GLN11
D	GLU69
D	G2P501

---

site_id	AD6
Number of Residues	19
Details	binding site for residue GTP F 501

Chain	Residue
F	GLY10
F	GLN11
F	ALA12
F	GLN15
F	ASP98
F	ALA99
F	ASN101
F	SER140
F	GLY143
F	GLY144
F	THR145
F	GLY146
F	ILE171
F	GLU183
F	ASN206
F	TYR224
F	ASN228
F	MG502
L	LYS252

---

site_id	AD7
Number of Residues	2
Details	binding site for residue MG F 502

Chain	Residue
F	GLN11
F	GTP501

---

site_id	AD8
Number of Residues	19
Details	binding site for residue GTP A 501

Chain	Residue
A	GLY10
A	GLN11
A	ALA12
A	GLN15
A	ASP98
A	ALA99
A	ASN101
A	SER140
A	GLY143
A	GLY144
A	THR145
A	GLY146
A	ILE171
A	GLU183
A	ASN206
A	TYR224
A	ASN228
A	MG502
I	LYS252

---

site_id	AD9
Number of Residues	2
Details	binding site for residue MG A 502

Chain	Residue
A	GLN11
A	GTP501

---

site_id	AE1
Number of Residues	19
Details	binding site for residue GTP B 501

Chain	Residue
B	GLY10
B	GLN11
B	ALA12
B	GLN15
B	ASP98
B	ALA99
B	ASN101
B	SER140
B	GLY143
B	GLY144
B	THR145
B	GLY146
B	ILE171
B	GLU183
B	ASN206
B	TYR224
B	ASN228
B	MG502
K	LYS252

---

site_id	AE2
Number of Residues	2
Details	binding site for residue MG B 502

Chain	Residue
B	GLN11
B	GTP501

---

site_id	AE3
Number of Residues	19
Details	binding site for residue G2P L 501

Chain	Residue
L	GLY10
L	GLN11
L	CYS12
L	GLN15
L	ALA97
L	GLY98
L	ASN99
L	SER138
L	GLY141
L	GLY142
L	THR143
L	GLY144
L	VAL169
L	ASP177
L	GLU181
L	ASN204
L	TYR222
L	ASN226
L	MG502

---

site_id	AE4
Number of Residues	3
Details	binding site for residue MG L 502

Chain	Residue
L	GLN11
L	GLU69
L	G2P501

---

site_id	AE5
Number of Residues	19
Details	binding site for residue GTP G 501

Chain	Residue
G	GLY10
G	GLN11
G	ALA12
G	GLN15
G	ASP98
G	ALA99
G	ASN101
G	SER140
G	GLY143
G	GLY144
G	THR145
G	GLY146
G	ILE171
G	GLU183
G	ASN206
G	TYR224
G	ASN228
G	MG502
J	LYS252

---

site_id	AE6
Number of Residues	2
Details	binding site for residue MG G 502

Chain	Residue
G	GLN11
G	GTP501

---

site_id	AE7
Number of Residues	4
Details	binding site for Di-peptide MET A 36 and PRO A 37

Chain	Residue
A	HIS28
A	GLY29
A	GLN35
A	HIS61

---

site_id	AE8
Number of Residues	4
Details	binding site for Di-peptide MET B 36 and PRO B 37

Chain	Residue
B	HIS28
B	GLY29
B	GLN35
B	HIS61

---

site_id	AE9
Number of Residues	4
Details	binding site for Di-peptide MET E 36 and PRO E 37

Chain	Residue
E	HIS28
E	GLY29
E	GLN35
E	HIS61

---

site_id	AF1
Number of Residues	4
Details	binding site for Di-peptide MET F 36 and PRO F 37

Chain	Residue
F	HIS28
F	GLY29
F	GLN35
F	HIS61

---

site_id	AF2
Number of Residues	4
Details	binding site for Di-peptide MET G 36 and PRO G 37

Chain	Residue
G	HIS28
G	GLY29
G	GLN35
G	HIS61

---

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
K	GLY140-GLY146
H	GLY142-GLY148

---

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
K	MET1-ILE4

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P68363

Chain	Residue	Details
H	GLU254
I	GLY144
I	ASN204
I	ASN226
J	GLN11
J	GLY142
J	THR143
J	GLY144
J	ASN204
J	ASN226
C	GLN11
E	GLU254
C	GLY142
C	THR143
C	GLY144
C	ASN204
C	ASN226
D	GLN11
D	GLY142
D	THR143
D	GLY144
D	ASN204
F	GLU254
D	ASN226
L	GLN11
L	GLY142
L	THR143
L	GLY144
L	ASN204
L	ASN226
A	GLU254
B	GLU254
G	GLU254
I	GLN11
I	GLY142
I	THR143

---

site_id	SWS_FT_FI2
Number of Residues	48
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P68363

Chain	Residue	Details
H	GLN11
E	GLU71
E	SER140
E	GLY144
E	THR145
E	THR179
E	ASN206
E	ASN228
F	GLN11
F	GLU71
F	SER140
H	GLU71
F	GLY144
F	THR145
F	THR179
F	ASN206
F	ASN228
A	GLN11
A	GLU71
A	SER140
A	GLY144
A	THR145
H	SER140
A	THR179
A	ASN206
A	ASN228
B	GLN11
B	GLU71
B	SER140
B	GLY144
B	THR145
B	THR179
B	ASN206
H	GLY144
B	ASN228
G	GLN11
G	GLU71
G	SER140
G	GLY144
G	THR145
G	THR179
G	ASN206
G	ASN228
H	THR145
H	THR179
H	ASN206
H	ASN228
E	GLN11

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:24906155

Chain	Residue	Details
H	LYS40
E	LYS40
F	LYS40
A	LYS40
B	LYS40
G	LYS40

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:P68373

Chain	Residue	Details
H	TYR282
E	TYR282
F	TYR282
A	TYR282
B	TYR282
G	TYR282

---