5JCA

NADP(H) bound NADH-dependent Ferredoxin:NADP Oxidoreductase (NfnI) from Pyrococcus furiosus

Functional Information from GO Data

Chain	GOid	namespace	contents
L	0004324	molecular_function	ferredoxin-NADP+ reductase activity
L	0005737	cellular_component	cytoplasm
L	0016491	molecular_function	oxidoreductase activity
L	0046872	molecular_function	metal ion binding
L	0051536	molecular_function	iron-sulfur cluster binding
L	0051538	molecular_function	3 iron, 4 sulfur cluster binding
L	0051539	molecular_function	4 iron, 4 sulfur cluster binding
S	0004324	molecular_function	ferredoxin-NADP+ reductase activity
S	0005737	cellular_component	cytoplasm
S	0006221	biological_process	pyrimidine nucleotide biosynthetic process
S	0016491	molecular_function	oxidoreductase activity
S	0046872	molecular_function	metal ion binding
S	0050660	molecular_function	flavin adenine dinucleotide binding
S	0051537	molecular_function	2 iron, 2 sulfur cluster binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue SF4 L 501

Chain	Residue
L	CYS56
L	CYS101
L	GLN106
L	CYS107
L	GLU126

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site_id	AC2
Number of Residues	5
Details	binding site for residue SF4 L 502

Chain	Residue
L	CYS111
L	CYS42
L	LEU43
L	CYS45
L	CYS52

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site_id	AC3
Number of Residues	36
Details	binding site for residue FAD L 503

Chain	Residue
L	VAL100
L	GLY161
L	ALA162
L	GLY163
L	PRO164
L	ALA165
L	GLU184
L	ALA185
L	LEU186
L	GLY191
L	VAL192
L	ILE197
L	ARG201
L	VAL225
L	VAL227
L	GLY246
L	THR247
L	GLY248
L	ASN303
L	THR304
L	ASP307
L	ARG333
L	PHE411
L	GLY443
L	ASP444
L	ALA450
L	THR451
L	VAL452
L	ALA455
L	NDP504
L	HOH615
L	HOH622
L	HOH720
L	HOH726
L	HOH835
L	HOH951

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site_id	AC4
Number of Residues	25
Details	binding site for residue NDP L 504

Chain	Residue
L	ARG253
L	TYR255
L	GLY302
L	ASN303
L	THR304
L	ALA305
L	TYR323
L	ARG324
L	ARG325
L	THR331
L	THR352
L	ARG382
L	ALA402
L	ILE403
L	GLY404
L	GLN405
L	GLU449
L	ALA450
L	FAD503
L	HOH604
L	HOH627
L	HOH647
L	HOH665
L	HOH671
L	HOH749

---

site_id	AC5
Number of Residues	7
Details	binding site for residue GOL L 505

Chain	Residue
L	ARG237
L	TYR240
L	ASP241
L	ALA242
L	PRO437
L	VAL439
L	HOH737

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site_id	AC6
Number of Residues	33
Details	binding site for residue FAD S 301

Chain	Residue
S	HOH411
S	HOH423
S	HOH444
S	HOH475
S	HOH476
S	HOH487
S	HOH493
S	HOH505
S	HOH531
S	HOH542
S	HOH561
S	HOH606
S	GLU49
S	ILE51
S	PRO52
S	LEU53
S	THR54
S	VAL68
S	ALA69
S	GLN70
S	VAL72
S	GLY73
S	THR75
S	THR76
S	VAL114
S	GLU118
S	ASN218
S	PRO219
S	ILE220
S	MET221
S	LEU263
S	GLU270
S	MG303

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site_id	AC7
Number of Residues	10
Details	binding site for residue FES S 302

Chain	Residue
S	MET221
S	VAL222
S	ASP223
S	GLY224
S	GLY226
S	MET227
S	CYS228
S	GLY229
S	CYS231
S	CYS243

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site_id	AC8
Number of Residues	5
Details	binding site for residue MG S 303

Chain	Residue
S	GLU49
S	FAD301
S	HOH411
S	HOH444
S	HOH561

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
S	CYS228
S	CYS231
S	CYS243
L	CYS56
L	CYS101
L	CYS107
L	CYS111

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