5IL1
Crystal structure of SAM-bound METTL3-METTL14 complex
Functional Information from GO Data
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 20 |
Details | binding site for residue SAM A 601 |
Chain | Residue |
A | CYS376 |
A | LYS513 |
A | PHE534 |
A | ARG536 |
A | HIS538 |
A | ASN539 |
A | ASN549 |
A | GLN550 |
A | HOH739 |
A | HOH749 |
A | HOH752 |
A | ASP377 |
A | HOH774 |
A | ILE378 |
A | ASP395 |
A | PRO397 |
A | TYR406 |
A | GLY407 |
A | LEU409 |
A | SER511 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue EDO A 602 |
Chain | Residue |
A | ASN445 |
A | TYR449 |
A | ARG451 |
A | HOH764 |
site_id | AC3 |
Number of Residues | 2 |
Details | binding site for residue EDO B 501 |
Chain | Residue |
A | TRP475 |
B | ARG254 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue EDO B 502 |
Chain | Residue |
B | LEU190 |
B | GLU192 |
B | TRP234 |
B | LYS326 |
B | ILE330 |
B | PHE331 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 5 |
Details | SITE: Interaction with METTL3 => ECO:0000269|PubMed:27281194, ECO:0007744|PDB:5IL0, ECO:0007744|PDB:5IL1, ECO:0007744|PDB:5IL2 |
Chain | Residue | Details |
B | TYR146 | |
B | ASP242 | |
B | ARG245 | |
B | ARG298 | |
B | SEP399 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:29348140, ECO:0007744|PDB:5IL0, ECO:0007744|PDB:5IL1, ECO:0007744|PDB:5IL2, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
B | SEP399 | |
A | LYS513 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | SITE: Interaction with METTL14 => ECO:0000269|PubMed:27281194, ECO:0007744|PDB:5IL1, ECO:0007744|PDB:5IL2 |
Chain | Residue | Details |
A | GLU438 | |
A | ARG441 |