5ICS

Crystal structure of 17beta-hydroxysteroid dehydrogenase type 14 apoenzyme.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)] activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006706	biological_process	steroid catabolic process
A	0008202	biological_process	steroid metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0042802	molecular_function	identical protein binding
A	0047045	molecular_function	testosterone 17-beta-dehydrogenase (NADP+) activity
C	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)] activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006706	biological_process	steroid catabolic process
C	0008202	biological_process	steroid metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0042802	molecular_function	identical protein binding
C	0047045	molecular_function	testosterone 17-beta-dehydrogenase (NADP+) activity
D	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)] activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006706	biological_process	steroid catabolic process
D	0008202	biological_process	steroid metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0042802	molecular_function	identical protein binding
D	0047045	molecular_function	testosterone 17-beta-dehydrogenase (NADP+) activity
F	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)] activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006706	biological_process	steroid catabolic process
F	0008202	biological_process	steroid metabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0042802	molecular_function	identical protein binding
F	0047045	molecular_function	testosterone 17-beta-dehydrogenase (NADP+) activity

Functional Information from PROSITE/UniProt

site_id	PS00061
Number of Residues	29
Details	ADH_SHORT Short-chain dehydrogenases/reductases family signature. SlvgaigqaqAvpYVATKGAVtAMTkALA

Chain	Residue	Details
A	SER141-ALA169

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001

Chain	Residue	Details
A	TYR154
C	TYR154
D	TYR154
F	TYR154

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site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
C	SER141
C	LYS158
D	VAL13
D	SER141
D	LYS158
F	VAL13
F	SER141
F	LYS158
A	VAL13
A	SER141
A	LYS158
C	VAL13

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