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5HLO

Crystal structure of calcium and zinc-bound human S100A8 in space group C2221

Functional Information from GO Data
ChainGOidnamespacecontents
A0002523biological_processleukocyte migration involved in inflammatory response
A0002544biological_processchronic inflammatory response
A0002790biological_processpeptide secretion
A0002793biological_processpositive regulation of peptide secretion
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0006914biological_processautophagy
A0006915biological_processapoptotic process
A0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
A0006935biological_processchemotaxis
A0006954biological_processinflammatory response
A0008017molecular_functionmicrotubule binding
A0008270molecular_functionzinc ion binding
A0010043biological_processresponse to zinc ion
A0014002biological_processastrocyte development
A0018119biological_processpeptidyl-cysteine S-nitrosylation
A0030307biological_processpositive regulation of cell growth
A0030593biological_processneutrophil chemotaxis
A0032119biological_processsequestering of zinc ion
A0032496biological_processresponse to lipopolysaccharide
A0034121biological_processregulation of toll-like receptor signaling pathway
A0034774cellular_componentsecretory granule lumen
A0035425biological_processautocrine signaling
A0035662molecular_functionToll-like receptor 4 binding
A0042742biological_processdefense response to bacterium
A0045087biological_processinnate immune response
A0045111cellular_componentintermediate filament cytoskeleton
A0045471biological_processresponse to ethanol
A0046872molecular_functionmetal ion binding
A0048306molecular_functioncalcium-dependent protein binding
A0050544molecular_functionarachidonic acid binding
A0050729biological_processpositive regulation of inflammatory response
A0050786molecular_functionRAGE receptor binding
A0050832biological_processdefense response to fungus
A0051092biological_processpositive regulation of NF-kappaB transcription factor activity
A0051493biological_processregulation of cytoskeleton organization
A0062023cellular_componentcollagen-containing extracellular matrix
A0070062cellular_componentextracellular exosome
A0070488biological_processneutrophil aggregation
A1990660cellular_componentcalprotectin complex
A2001244biological_processpositive regulation of intrinsic apoptotic signaling pathway
B0002523biological_processleukocyte migration involved in inflammatory response
B0002544biological_processchronic inflammatory response
B0002790biological_processpeptide secretion
B0002793biological_processpositive regulation of peptide secretion
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0006914biological_processautophagy
B0006915biological_processapoptotic process
B0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
B0006935biological_processchemotaxis
B0006954biological_processinflammatory response
B0008017molecular_functionmicrotubule binding
B0008270molecular_functionzinc ion binding
B0010043biological_processresponse to zinc ion
B0014002biological_processastrocyte development
B0018119biological_processpeptidyl-cysteine S-nitrosylation
B0030307biological_processpositive regulation of cell growth
B0030593biological_processneutrophil chemotaxis
B0032119biological_processsequestering of zinc ion
B0032496biological_processresponse to lipopolysaccharide
B0034121biological_processregulation of toll-like receptor signaling pathway
B0034774cellular_componentsecretory granule lumen
B0035425biological_processautocrine signaling
B0035662molecular_functionToll-like receptor 4 binding
B0042742biological_processdefense response to bacterium
B0045087biological_processinnate immune response
B0045111cellular_componentintermediate filament cytoskeleton
B0045471biological_processresponse to ethanol
B0046872molecular_functionmetal ion binding
B0048306molecular_functioncalcium-dependent protein binding
B0050544molecular_functionarachidonic acid binding
B0050729biological_processpositive regulation of inflammatory response
B0050786molecular_functionRAGE receptor binding
B0050832biological_processdefense response to fungus
B0051092biological_processpositive regulation of NF-kappaB transcription factor activity
B0051493biological_processregulation of cytoskeleton organization
B0062023cellular_componentcollagen-containing extracellular matrix
B0070062cellular_componentextracellular exosome
B0070488biological_processneutrophil aggregation
B1990660cellular_componentcalprotectin complex
B2001244biological_processpositive regulation of intrinsic apoptotic signaling pathway
C0002523biological_processleukocyte migration involved in inflammatory response
C0002544biological_processchronic inflammatory response
C0002790biological_processpeptide secretion
C0002793biological_processpositive regulation of peptide secretion
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0006914biological_processautophagy
C0006915biological_processapoptotic process
C0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
C0006935biological_processchemotaxis
C0006954biological_processinflammatory response
C0008017molecular_functionmicrotubule binding
C0008270molecular_functionzinc ion binding
C0010043biological_processresponse to zinc ion
C0014002biological_processastrocyte development
C0018119biological_processpeptidyl-cysteine S-nitrosylation
C0030307biological_processpositive regulation of cell growth
C0030593biological_processneutrophil chemotaxis
C0032119biological_processsequestering of zinc ion
C0032496biological_processresponse to lipopolysaccharide
C0034121biological_processregulation of toll-like receptor signaling pathway
C0034774cellular_componentsecretory granule lumen
C0035425biological_processautocrine signaling
C0035662molecular_functionToll-like receptor 4 binding
C0042742biological_processdefense response to bacterium
C0045087biological_processinnate immune response
C0045111cellular_componentintermediate filament cytoskeleton
C0045471biological_processresponse to ethanol
C0046872molecular_functionmetal ion binding
C0048306molecular_functioncalcium-dependent protein binding
C0050544molecular_functionarachidonic acid binding
C0050729biological_processpositive regulation of inflammatory response
C0050786molecular_functionRAGE receptor binding
C0050832biological_processdefense response to fungus
C0051092biological_processpositive regulation of NF-kappaB transcription factor activity
C0051493biological_processregulation of cytoskeleton organization
C0062023cellular_componentcollagen-containing extracellular matrix
C0070062cellular_componentextracellular exosome
C0070488biological_processneutrophil aggregation
C1990660cellular_componentcalprotectin complex
C2001244biological_processpositive regulation of intrinsic apoptotic signaling pathway
D0002523biological_processleukocyte migration involved in inflammatory response
D0002544biological_processchronic inflammatory response
D0002790biological_processpeptide secretion
D0002793biological_processpositive regulation of peptide secretion
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005886cellular_componentplasma membrane
D0006914biological_processautophagy
D0006915biological_processapoptotic process
D0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
D0006935biological_processchemotaxis
D0006954biological_processinflammatory response
D0008017molecular_functionmicrotubule binding
D0008270molecular_functionzinc ion binding
D0010043biological_processresponse to zinc ion
D0014002biological_processastrocyte development
D0018119biological_processpeptidyl-cysteine S-nitrosylation
D0030307biological_processpositive regulation of cell growth
D0030593biological_processneutrophil chemotaxis
D0032119biological_processsequestering of zinc ion
D0032496biological_processresponse to lipopolysaccharide
D0034121biological_processregulation of toll-like receptor signaling pathway
D0034774cellular_componentsecretory granule lumen
D0035425biological_processautocrine signaling
D0035662molecular_functionToll-like receptor 4 binding
D0042742biological_processdefense response to bacterium
D0045087biological_processinnate immune response
D0045111cellular_componentintermediate filament cytoskeleton
D0045471biological_processresponse to ethanol
D0046872molecular_functionmetal ion binding
D0048306molecular_functioncalcium-dependent protein binding
D0050544molecular_functionarachidonic acid binding
D0050729biological_processpositive regulation of inflammatory response
D0050786molecular_functionRAGE receptor binding
D0050832biological_processdefense response to fungus
D0051092biological_processpositive regulation of NF-kappaB transcription factor activity
D0051493biological_processregulation of cytoskeleton organization
D0062023cellular_componentcollagen-containing extracellular matrix
D0070062cellular_componentextracellular exosome
D0070488biological_processneutrophil aggregation
D1990660cellular_componentcalprotectin complex
D2001244biological_processpositive regulation of intrinsic apoptotic signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue CA A 101
ChainResidue
AASP59
AASN61
AASP63
AALA65
AGLU70
AHOH202

site_idAC2
Number of Residues6
Detailsbinding site for residue CA A 102
ChainResidue
AALA28
ATYR30
AHOH203
ASER20
ALYS23
AASN25

site_idAC3
Number of Residues4
Detailsbinding site for residue ZN A 103
ChainResidue
AHIS17
ACAC105
CHIS83
CCL104

site_idAC4
Number of Residues4
Detailsbinding site for residue ZN A 104
ChainResidue
AHIS27
ACAC105
ACL108
CHIS91

site_idAC5
Number of Residues10
Detailsbinding site for residue CAC A 105
ChainResidue
AHIS17
AHIS27
AZN103
AZN104
ACL108
CHIS83
CHIS87
CSER90
CHIS91
CCL104

site_idAC6
Number of Residues4
Detailsbinding site for residue ZN A 106
ChainResidue
AHIS83
AHIS87
CHIS17
CHIS27

site_idAC7
Number of Residues5
Detailsbinding site for residue CL A 107
ChainResidue
AHIS87
CHIS27
DPHE26
DHOH420
DHOH435

site_idAC8
Number of Residues3
Detailsbinding site for residue CL A 108
ChainResidue
AZN104
ACAC105
AHOH252

site_idAC9
Number of Residues2
Detailsbinding site for residue ACT A 109
ChainResidue
ATYR30
CTHR62

site_idAD1
Number of Residues6
Detailsbinding site for residue CA B 101
ChainResidue
BSER20
BLYS23
BASN25
BALA28
BTYR30
BHOH209

site_idAD2
Number of Residues6
Detailsbinding site for residue CA B 102
ChainResidue
BASP59
BASN61
BASP63
BALA65
BGLU70
BHOH207

site_idAD3
Number of Residues4
Detailsbinding site for residue ZN B 103
ChainResidue
BHIS17
BCAC110
DHIS83
DCL104

site_idAD4
Number of Residues4
Detailsbinding site for residue ZN B 104
ChainResidue
BHIS27
BCL107
BCAC110
DHIS91

site_idAD5
Number of Residues4
Detailsbinding site for residue ZN B 105
ChainResidue
BHIS83
BHIS87
DHIS17
DHIS27

site_idAD6
Number of Residues4
Detailsbinding site for residue CL B 106
ChainResidue
BHIS87
CPHE26
CHOH223
DHIS27

site_idAD7
Number of Residues4
Detailsbinding site for residue CL B 107
ChainResidue
BHIS27
BGLU93
BZN104
BCAC110

site_idAD8
Number of Residues4
Detailsbinding site for residue ACT B 108
ChainResidue
BLYS7
BSER11
BHOH201
DLYS7

site_idAD9
Number of Residues3
Detailsbinding site for residue ACT B 109
ChainResidue
BILE46
BALA81
BHOH230

site_idAE1
Number of Residues11
Detailsbinding site for residue CAC B 110
ChainResidue
BHIS17
BPHE26
BHIS27
BZN103
BZN104
BCL107
DHIS83
DHIS87
DSER90
DHIS91
DCL104

site_idAE2
Number of Residues6
Detailsbinding site for residue CA C 101
ChainResidue
CHOH210
CSER20
CLYS23
CASN25
CALA28
CTYR30

site_idAE3
Number of Residues6
Detailsbinding site for residue CA C 102
ChainResidue
CASP59
CASN61
CASP63
CALA65
CGLU70
CHOH205

site_idAE4
Number of Residues4
Detailsbinding site for residue ZN C 103
ChainResidue
CGLU57
CHIS87
CGLU93
CCL105

site_idAE5
Number of Residues6
Detailsbinding site for residue CL C 104
ChainResidue
ATYR16
AHIS17
AHIS27
AZN103
ACAC105
CHIS83

site_idAE6
Number of Residues3
Detailsbinding site for residue CL C 105
ChainResidue
CLYS49
CGLU57
CZN103

site_idAE7
Number of Residues5
Detailsbinding site for residue CA D 101
ChainResidue
DSER20
DLYS23
DASN25
DALA28
DHOH406

site_idAE8
Number of Residues6
Detailsbinding site for residue CA D 102
ChainResidue
DASP59
DASN61
DASP63
DALA65
DGLU70
DHOH405

site_idAE9
Number of Residues4
Detailsbinding site for residue ZN D 103
ChainResidue
DGLU57
DHIS87
DGLU93
DCL105

site_idAF1
Number of Residues6
Detailsbinding site for residue CL D 104
ChainResidue
BTYR16
BHIS17
BHIS27
BZN103
BCAC110
DHIS83

site_idAF2
Number of Residues3
Detailsbinding site for residue CL D 105
ChainResidue
DGLU57
DGLU93
DZN103

site_idAF3
Number of Residues3
Detailsbinding site for residue ACT D 106
ChainResidue
BTYR30
DASN61
DTHR62

Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DINTDGAVNfqEF
ChainResidueDetails
AASP59-PHE71

site_idPS00303
Number of Residues22
DetailsS100_CABP S-100/ICaBP type calcium binding protein signature. WFkeLDintDgavNFqEFliLV
ChainResidueDetails
ATRP54-VAL75

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues20
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
AHIS17
AHIS27
DHIS27
DASP33
DHIS83
DHIS87
AASP33
AHIS83
AHIS87
BHIS17
BHIS27
BASP33
BHIS83
BHIS87
CHIS17
CHIS27
CASP33
CHIS83
CHIS87
DHIS17

site_idSWS_FT_FI2
Number of Residues16
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448
ChainResidueDetails
BASP59
BASN61
BASP63
BGLU70
CASP59
CASN61
CASP63
CGLU70
DASP59
DASN61
DASP63
DGLU70
AASP59
AASN61
AASP63
AGLU70

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:18832721
ChainResidueDetails
ACYS42
BCYS42
CCYS42
DCYS42

220472

PDB entries from 2024-05-29

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