5HDN
Crystal structure of heat shock factor1-DBD complex with ds-DNA and TtT
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0043565 | molecular_function | sequence-specific DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0043565 | molecular_function | sequence-specific DNA binding |
| C | 0003700 | molecular_function | DNA-binding transcription factor activity |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0043565 | molecular_function | sequence-specific DNA binding |
| D | 0003700 | molecular_function | DNA-binding transcription factor activity |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0043565 | molecular_function | sequence-specific DNA binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue CIT A 201 |
| Chain | Residue |
| A | SER38 |
| B | GLN100 |
| B | PRO102 |
| B | HOH358 |
| A | PRO39 |
| A | SER40 |
| A | SER43 |
| A | VAL81 |
| A | GLU98 |
| A | HOH326 |
| A | HOH340 |
| B | ARG79 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 202 |
| Chain | Residue |
| A | LEU25 |
| A | VAL26 |
| A | ASP28 |
| A | THR31 |
| A | ASP32 |
| A | ILE35 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue NA B 201 |
| Chain | Residue |
| B | LEU25 |
| B | VAL26 |
| B | ASP28 |
| B | THR31 |
| B | ASP32 |
| B | ILE35 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue NA D 201 |
| Chain | Residue |
| D | LEU25 |
| D | VAL26 |
| D | ASP28 |
| D | THR31 |
| D | ASP32 |
| D | ILE35 |
Functional Information from PROSITE/UniProt
| site_id | PS00434 |
| Number of Residues | 25 |
| Details | HSF_DOMAIN HSF-type DNA-binding domain signature. LpkyFKHnNmASFVRQLNmYgFRKV |
| Chain | Residue | Details |
| A | LEU57-VAL81 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:19229036, ECO:0000269|PubMed:24581496 |
| Chain | Residue | Details |
| A | LYS80 | |
| B | LYS80 | |
| C | LYS80 | |
| D | LYS80 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:24581496 |
| Chain | Residue | Details |
| A | LYS91 | |
| B | LYS91 | |
| C | LYS91 | |
| D | LYS91 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:24581496, ECO:0000269|PubMed:26754925 |
| Chain | Residue | Details |
| A | LYS118 | |
| B | LYS118 | |
| C | LYS118 | |
| D | LYS118 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS91 | |
| B | LYS91 | |
| C | LYS91 | |
| D | LYS91 |
