5FT6
Crystal structure of the cysteine desulfurase CsdA (S-sulfonic acid) from Escherichia coli at 2.050 Angstroem resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000096 | biological_process | sulfur amino acid metabolic process |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0006534 | biological_process | cysteine metabolic process |
| A | 0008826 | molecular_function | cysteine sulfinate desulfinase activity |
| A | 0009000 | molecular_function | selenocysteine lyase activity |
| A | 0016226 | biological_process | iron-sulfur cluster assembly |
| A | 0016261 | biological_process | selenocysteine catabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016783 | molecular_function | sulfurtransferase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019448 | biological_process | L-cysteine catabolic process |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0031071 | molecular_function | cysteine desulfurase activity |
| A | 0072348 | biological_process | sulfur compound transport |
| A | 1990221 | cellular_component | L-cysteine desulfurase complex |
| B | 0000096 | biological_process | sulfur amino acid metabolic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0006534 | biological_process | cysteine metabolic process |
| B | 0008826 | molecular_function | cysteine sulfinate desulfinase activity |
| B | 0009000 | molecular_function | selenocysteine lyase activity |
| B | 0016226 | biological_process | iron-sulfur cluster assembly |
| B | 0016261 | biological_process | selenocysteine catabolic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016783 | molecular_function | sulfurtransferase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016829 | molecular_function | lyase activity |
| B | 0019448 | biological_process | L-cysteine catabolic process |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0031071 | molecular_function | cysteine desulfurase activity |
| B | 0072348 | biological_process | sulfur compound transport |
| B | 1990221 | cellular_component | L-cysteine desulfurase complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 501 |
| Chain | Residue |
| A | ALA47 |
| A | THR62 |
| A | HOH2439 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 502 |
| Chain | Residue |
| A | GOL505 |
| A | HOH2205 |
| A | GLY109 |
| A | GLY134 |
| A | LYS136 |
| A | PRO316 |
| A | ASP393 |
| A | GLU397 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 503 |
| Chain | Residue |
| A | ARG60 |
| A | ARG64 |
| A | LYS71 |
| A | GLU287 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 504 |
| Chain | Residue |
| A | ASP310 |
| A | ALA313 |
| A | HOH2349 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 505 |
| Chain | Residue |
| A | LYS136 |
| A | LYS314 |
| A | ARG315 |
| A | GOL502 |
| A | HOH2196 |
| A | HOH2355 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 506 |
| Chain | Residue |
| A | TYR65 |
| A | ARG69 |
| A | TRP86 |
| A | HOH2111 |
| A | HOH2112 |
| A | HOH2116 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG A 507 |
| Chain | Residue |
| A | MET1 |
| A | ILE157 |
| A | THR158 |
| A | PRO159 |
| A | ALA189 |
| site_id | AC8 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PLP A 1222 |
| Chain | Residue |
| A | THR90 |
| A | THR91 |
| A | HIS119 |
| A | ASN171 |
| A | ASP196 |
| A | ALA198 |
| A | GLN199 |
| A | SER219 |
| A | HIS221 |
| A | LYS222 |
| A | HOH2140 |
| A | HOH2143 |
| A | HOH2441 |
| B | THR273 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 501 |
| Chain | Residue |
| B | TYR65 |
| B | ARG69 |
| B | TRP86 |
| B | TRP267 |
| B | HOH2068 |
| B | HOH2247 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 502 |
| Chain | Residue |
| A | HOH2436 |
| B | LEU307 |
| B | LYS382 |
| B | ASP386 |
| B | VAL389 |
| B | HOH2212 |
| B | HOH2248 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 503 |
| Chain | Residue |
| B | THR273 |
| B | VAL276 |
| B | HOH2249 |
| B | HOH2250 |
| B | HOH2251 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG B 504 |
| Chain | Residue |
| A | HOH2385 |
| B | THR306 |
| B | GLU309 |
| B | ASP310 |
| B | ASP325 |
| site_id | BC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE PLP B 1222 |
| Chain | Residue |
| A | THR273 |
| A | HOH2315 |
| A | HOH2316 |
| A | HOH2319 |
| B | THR90 |
| B | THR91 |
| B | HIS119 |
| B | ASN171 |
| B | ASP196 |
| B | ALA198 |
| B | GLN199 |
| B | SER219 |
| B | HIS221 |
| B | LYS222 |
| B | HOH2088 |
Functional Information from PROSITE/UniProt
| site_id | PS00595 |
| Number of Residues | 20 |
| Details | AA_TRANSFER_CLASS_5 Aminotransferases class-V pyridoxal-phosphate attachment site. IDFYafSGHKlygpt.GiGvL |
| Chain | Residue | Details |
| A | ILE213-LEU232 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Cysteine persulfide intermediate => ECO:0000305|PubMed:10739946 |
| Chain | Residue | Details |
| A | CSU358 | |
| B | CSU358 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS222 | |
| B | LYS222 |
