5FAU
wild-type choline TMA lyase in complex with choline
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016840 | molecular_function | carbon-nitrogen lyase activity |
| A | 0033265 | molecular_function | choline binding |
| A | 0042426 | biological_process | choline catabolic process |
| A | 0042803 | molecular_function | protein homodimerization activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016840 | molecular_function | carbon-nitrogen lyase activity |
| B | 0033265 | molecular_function | choline binding |
| B | 0042426 | biological_process | choline catabolic process |
| B | 0042803 | molecular_function | protein homodimerization activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0016829 | molecular_function | lyase activity |
| C | 0016840 | molecular_function | carbon-nitrogen lyase activity |
| C | 0033265 | molecular_function | choline binding |
| C | 0042426 | biological_process | choline catabolic process |
| C | 0042803 | molecular_function | protein homodimerization activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0016829 | molecular_function | lyase activity |
| D | 0016840 | molecular_function | carbon-nitrogen lyase activity |
| D | 0033265 | molecular_function | choline binding |
| D | 0042426 | biological_process | choline catabolic process |
| D | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue CHT A 901 |
| Chain | Residue |
| A | TYR208 |
| A | ASP216 |
| A | GLY335 |
| A | GLY488 |
| A | CYS489 |
| A | GLU491 |
| A | TYR506 |
| A | LEU698 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 902 |
| Chain | Residue |
| A | LEU536 |
| A | ASN638 |
| A | GLU639 |
| A | LYS642 |
| A | HOH1009 |
| A | HOH1010 |
| A | HOH1257 |
| A | HIS519 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue CHT B 901 |
| Chain | Residue |
| B | TYR208 |
| B | ASP216 |
| B | THR334 |
| B | GLY488 |
| B | CYS489 |
| B | GLU491 |
| B | THR502 |
| B | TYR506 |
| B | LEU698 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | binding site for residue GOL B 902 |
| Chain | Residue |
| B | HIS677 |
| B | GLU680 |
| B | THR681 |
| B | ARG684 |
| B | ASN752 |
| B | HOH1146 |
| B | HOH1181 |
| B | HOH1202 |
| B | HOH1305 |
| C | ILE478 |
| C | GLU479 |
| C | ARG482 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 903 |
| Chain | Residue |
| B | HIS519 |
| B | LEU536 |
| B | ASN638 |
| B | GLU639 |
| B | LYS642 |
| B | HOH1107 |
| B | HOH1259 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue CHT C 901 |
| Chain | Residue |
| C | TYR208 |
| C | ASP216 |
| C | THR334 |
| C | GLY488 |
| C | CYS489 |
| C | GLU491 |
| C | THR502 |
| C | TYR506 |
| C | LEU698 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | binding site for residue GOL C 902 |
| Chain | Residue |
| B | ILE478 |
| B | GLU479 |
| B | ARG482 |
| C | HIS677 |
| C | GLU680 |
| C | THR681 |
| C | ARG684 |
| C | ASN752 |
| C | HOH1157 |
| C | HOH1262 |
| C | HOH1428 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue GOL C 903 |
| Chain | Residue |
| C | LEU517 |
| C | HIS519 |
| C | LEU536 |
| C | ASN638 |
| C | LYS642 |
| C | HOH1115 |
| C | HOH1118 |
| C | HOH1192 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue GOL C 904 |
| Chain | Residue |
| C | LEU536 |
| C | SER537 |
| C | TYR539 |
| C | VAL626 |
| C | THR633 |
| C | LEU634 |
| C | ALA635 |
| C | HOH1449 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue CHT D 901 |
| Chain | Residue |
| D | TYR208 |
| D | ASP216 |
| D | GLY335 |
| D | GLY488 |
| D | CYS489 |
| D | GLU491 |
| D | TYR506 |
| D | LEU698 |
| site_id | AD2 |
| Number of Residues | 9 |
| Details | binding site for residue GOL D 902 |
| Chain | Residue |
| D | LEU517 |
| D | HIS519 |
| D | LEU536 |
| D | ASN638 |
| D | GLU639 |
| D | LYS642 |
| D | HOH1006 |
| D | HOH1141 |
| D | HOH1280 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL D 903 |
| Chain | Residue |
| D | GLY597 |
| D | GLY598 |
| D | ALA599 |
| D | MET600 |
| D | ASN602 |
| D | HOH1020 |
| D | GLY586 |
| D | ARG592 |
Functional Information from PROSITE/UniProt
| site_id | PS00850 |
| Number of Residues | 9 |
| Details | GLY_RADICAL_1 Glycine radical domain signature. VvRVAGYSA |
| Chain | Residue | Details |
| A | VAL816-ALA824 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Cysteine radical intermediate => ECO:0000255|HAMAP-Rule:MF_02058, ECO:0000305|PubMed:23151509, ECO:0000305|PubMed:24854437 |
| Chain | Residue | Details |
| A | CYS489 | |
| B | CYS489 | |
| C | CYS489 | |
| D | CYS489 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_02058, ECO:0000305|PubMed:24854437 |
| Chain | Residue | Details |
| A | GLU491 | |
| B | GLU491 | |
| C | GLU491 | |
| D | GLU491 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Glycine radical => ECO:0000255|HAMAP-Rule:MF_02058, ECO:0000305|PubMed:23151509, ECO:0000305|PubMed:24854437 |
| Chain | Residue | Details |
| A | GLY821 | |
| B | GLY821 | |
| C | GLY821 | |
| D | GLY821 |
