5EX3

Crystal structure of human SMYD3 in complex with a VEGFR1 peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
A	0000993	molecular_function	RNA polymerase II complex binding
A	0001162	molecular_function	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006325	biological_process	chromatin organization
A	0006334	biological_process	nucleosome assembly
A	0008168	molecular_function	methyltransferase activity
A	0014904	biological_process	myotube cell development
A	0032259	biological_process	methylation
A	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
A	0042054	molecular_function	histone methyltransferase activity
A	0045184	biological_process	establishment of protein localization
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046872	molecular_function	metal ion binding
A	0071549	biological_process	cellular response to dexamethasone stimulus
A	0140939	molecular_function	histone H4 methyltransferase activity
A	0140954	molecular_function	histone H3K36 dimethyltransferase activity
A	0140999	molecular_function	histone H3K4 trimethyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 501

Chain	Residue
A	CYS49
A	CYS52
A	CYS71
A	CYS75

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 502

Chain	Residue
A	CYS62
A	CYS65
A	HIS83
A	CYS87

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 503

Chain	Residue
A	CYS261
A	CYS263
A	CYS266
A	CYS208

---

site_id	AC4
Number of Residues	13
Details	binding site for residue SAH A 504

Chain	Residue
A	ARG14
A	ASN16
A	TYR124
A	ASN132
A	SER202
A	LEU203
A	ASN205
A	HIS206
A	TYR239
A	TYR257
A	PHE259
A	HOH643
D	MLY831

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ACY A 505

Chain	Residue
A	GLN160
A	ASP161
A	HOH617
A	HOH665

---

site_id	AC6
Number of Residues	3
Details	binding site for residue ACY A 506

Chain	Residue
A	LEU276
A	THR277
A	GLY278

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ACY A 507

Chain	Residue
A	ALA73
A	ARG394
A	PHE397
A	ASP398

---

Functional Information from PROSITE/UniProt

site_id	PS01360
Number of Residues	39
Details	ZF_MYND_1 Zinc finger MYND-type signature. Cdr..Cllgkeklmr........CsqCrvakYCsakCqkkawpd..Hkre.C

Chain	Residue	Details
A	CYS49-CYS87

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
D	LEU833

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|Ref.12

Chain	Residue	Details
A	ARG14
A	ASN205

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00134

Chain	Residue	Details
A	CYS49
A	CYS52
A	CYS62
A	CYS65
A	CYS71
A	CYS75
A	HIS83
A	CYS87

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00190, ECO:0000269|Ref.12

Chain	Residue	Details
A	TYR124
A	ASN132
A	ASN181
A	TYR239
A	PHE259

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
A	MET1

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	THR22

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