5EDV
Structure of the HOIP-RBR/UbcH5B~ubiquitin transfer complex
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004842 | molecular_function | ubiquitin-protein transferase activity |
A | 0008270 | molecular_function | zinc ion binding |
A | 0071797 | cellular_component | LUBAC complex |
B | 0004842 | molecular_function | ubiquitin-protein transferase activity |
B | 0008270 | molecular_function | zinc ion binding |
B | 0071797 | cellular_component | LUBAC complex |
C | 0000151 | cellular_component | ubiquitin ligase complex |
C | 0000209 | biological_process | protein polyubiquitination |
C | 0004842 | molecular_function | ubiquitin-protein transferase activity |
C | 0005515 | molecular_function | protein binding |
C | 0005524 | molecular_function | ATP binding |
C | 0005634 | cellular_component | nucleus |
C | 0005654 | cellular_component | nucleoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
C | 0016567 | biological_process | protein ubiquitination |
C | 0016740 | molecular_function | transferase activity |
C | 0019787 | molecular_function | ubiquitin-like protein transferase activity |
C | 0031625 | molecular_function | ubiquitin protein ligase binding |
C | 0032991 | cellular_component | protein-containing complex |
C | 0036211 | biological_process | protein modification process |
C | 0051865 | biological_process | protein autoubiquitination |
C | 0061630 | molecular_function | ubiquitin protein ligase activity |
C | 0061631 | molecular_function | ubiquitin conjugating enzyme activity |
C | 0070062 | cellular_component | extracellular exosome |
C | 0070936 | biological_process | protein K48-linked ubiquitination |
D | 0000151 | cellular_component | ubiquitin ligase complex |
D | 0000209 | biological_process | protein polyubiquitination |
D | 0004842 | molecular_function | ubiquitin-protein transferase activity |
D | 0005515 | molecular_function | protein binding |
D | 0005524 | molecular_function | ATP binding |
D | 0005634 | cellular_component | nucleus |
D | 0005654 | cellular_component | nucleoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
D | 0016567 | biological_process | protein ubiquitination |
D | 0016740 | molecular_function | transferase activity |
D | 0019787 | molecular_function | ubiquitin-like protein transferase activity |
D | 0031625 | molecular_function | ubiquitin protein ligase binding |
D | 0032991 | cellular_component | protein-containing complex |
D | 0036211 | biological_process | protein modification process |
D | 0051865 | biological_process | protein autoubiquitination |
D | 0061630 | molecular_function | ubiquitin protein ligase activity |
D | 0061631 | molecular_function | ubiquitin conjugating enzyme activity |
D | 0070062 | cellular_component | extracellular exosome |
D | 0070936 | biological_process | protein K48-linked ubiquitination |
I | 0000151 | cellular_component | ubiquitin ligase complex |
I | 0000209 | biological_process | protein polyubiquitination |
I | 0004842 | molecular_function | ubiquitin-protein transferase activity |
I | 0005515 | molecular_function | protein binding |
I | 0005524 | molecular_function | ATP binding |
I | 0005634 | cellular_component | nucleus |
I | 0005654 | cellular_component | nucleoplasm |
I | 0005829 | cellular_component | cytosol |
I | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
I | 0016567 | biological_process | protein ubiquitination |
I | 0016740 | molecular_function | transferase activity |
I | 0019787 | molecular_function | ubiquitin-like protein transferase activity |
I | 0031625 | molecular_function | ubiquitin protein ligase binding |
I | 0032991 | cellular_component | protein-containing complex |
I | 0036211 | biological_process | protein modification process |
I | 0051865 | biological_process | protein autoubiquitination |
I | 0061630 | molecular_function | ubiquitin protein ligase activity |
I | 0061631 | molecular_function | ubiquitin conjugating enzyme activity |
I | 0070062 | cellular_component | extracellular exosome |
I | 0070936 | biological_process | protein K48-linked ubiquitination |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | binding site for residue ZN A 2001 |
Chain | Residue |
A | CYS699 |
A | VAL701 |
A | CYS702 |
A | CYS722 |
A | CYS725 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue ZN A 2002 |
Chain | Residue |
A | CYS717 |
A | CYS719 |
A | CYS744 |
A | CYS747 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue ZN A 2003 |
Chain | Residue |
A | CYS799 |
A | CYS802 |
A | CYS817 |
A | CYS820 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue ZN A 2004 |
Chain | Residue |
A | CYS825 |
A | CYS828 |
A | HIS836 |
A | CYS841 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue ZN A 2005 |
Chain | Residue |
A | CYS871 |
A | CYS874 |
A | CYS890 |
A | CYS893 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue ZN A 2006 |
Chain | Residue |
A | CYS898 |
A | CYS901 |
A | HIS926 |
A | CYS930 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue ZN A 2007 |
Chain | Residue |
A | CYS911 |
A | CYS916 |
A | HIS923 |
A | HIS925 |
site_id | AC8 |
Number of Residues | 4 |
Details | binding site for residue ZN A 2008 |
Chain | Residue |
A | CYS969 |
A | CYS986 |
A | CYS998 |
A | HIS1001 |
site_id | AC9 |
Number of Residues | 5 |
Details | binding site for residue ZN B 2001 |
Chain | Residue |
B | CYS699 |
B | VAL701 |
B | CYS702 |
B | CYS722 |
B | CYS725 |
site_id | AD1 |
Number of Residues | 4 |
Details | binding site for residue ZN B 2002 |
Chain | Residue |
B | CYS717 |
B | CYS719 |
B | CYS744 |
B | CYS747 |
site_id | AD2 |
Number of Residues | 4 |
Details | binding site for residue ZN B 2003 |
Chain | Residue |
B | CYS799 |
B | CYS802 |
B | CYS817 |
B | CYS820 |
site_id | AD3 |
Number of Residues | 4 |
Details | binding site for residue ZN B 2004 |
Chain | Residue |
B | CYS825 |
B | CYS828 |
B | HIS836 |
B | CYS841 |
site_id | AD4 |
Number of Residues | 4 |
Details | binding site for residue ZN B 2005 |
Chain | Residue |
B | CYS871 |
B | CYS874 |
B | CYS890 |
B | CYS893 |
site_id | AD5 |
Number of Residues | 4 |
Details | binding site for residue ZN B 2006 |
Chain | Residue |
B | CYS898 |
B | CYS901 |
B | HIS926 |
B | CYS930 |
site_id | AD6 |
Number of Residues | 4 |
Details | binding site for residue ZN B 2007 |
Chain | Residue |
B | CYS911 |
B | CYS916 |
B | HIS923 |
B | HIS925 |
site_id | AD7 |
Number of Residues | 4 |
Details | binding site for residue ZN B 2008 |
Chain | Residue |
B | CYS969 |
B | CYS986 |
B | CYS998 |
B | HIS1001 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | SITE: Interacts with activating enzyme |
Chain | Residue | Details |
E | ARG54 | |
E | ARG72 | |
F | ARG54 | |
F | ARG72 | |
G | ARG54 | |
G | ARG72 | |
H | ARG54 | |
H | ARG72 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | SITE: Essential for function |
Chain | Residue | Details |
E | HIS68 | |
F | HIS68 | |
G | HIS68 | |
H | HIS68 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 |
Chain | Residue | Details |
E | SER65 | |
F | SER65 | |
G | SER65 | |
H | SER65 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | MOD_RES: (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 |
Chain | Residue | Details |
E | THR66 | |
F | THR66 | |
G | THR66 | |
H | THR66 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | MOD_RES: ADP-ribosylglycine => ECO:0000269|PubMed:28525742 |
Chain | Residue | Details |
E | GLY76 | |
F | GLY76 | |
G | GLY76 | |
H | GLY76 | |
B | CYS699 | |
B | CYS702 | |
B | CYS722 | |
B | CYS725 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 |
Chain | Residue | Details |
E | LYS6 | |
F | LYS6 | |
G | LYS6 | |
H | LYS6 | |
B | CYS717 | |
B | CYS719 | |
B | CYS744 | |
B | CYS747 |
site_id | SWS_FT_FI7 |
Number of Residues | 8 |
Details | CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) |
Chain | Residue | Details |
A | CYS799 | |
A | CYS874 | |
A | CYS890 | |
A | CYS893 | |
A | CYS898 | |
A | CYS901 | |
A | CYS916 | |
A | HIS925 | |
B | CYS799 | |
B | CYS802 | |
B | CYS817 | |
E | GLY76 | |
B | CYS820 | |
B | CYS825 | |
B | CYS828 | |
B | HIS836 | |
B | CYS841 | |
B | CYS871 | |
B | CYS874 | |
B | CYS890 | |
B | CYS893 | |
B | CYS898 | |
A | CYS817 | |
B | CYS901 | |
B | CYS916 | |
B | HIS925 | |
F | GLY76 | |
A | CYS825 | |
G | GLY76 | |
A | HIS836 | |
H | GLY76 | |
A | CYS871 |
site_id | SWS_FT_FI8 |
Number of Residues | 8 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 |
Chain | Residue | Details |
E | LYS11 | |
E | LYS48 | |
F | LYS11 | |
F | LYS48 | |
G | LYS11 | |
G | LYS48 | |
H | LYS11 | |
H | LYS48 |
site_id | SWS_FT_FI9 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 |
Chain | Residue | Details |
E | LYS27 | |
F | LYS27 | |
G | LYS27 | |
H | LYS27 |
site_id | SWS_FT_FI10 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 |
Chain | Residue | Details |
E | LYS29 | |
F | LYS29 | |
G | LYS29 | |
H | LYS29 |
site_id | SWS_FT_FI11 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 |
Chain | Residue | Details |
E | LYS33 | |
F | LYS33 | |
G | LYS33 | |
H | LYS33 |
site_id | SWS_FT_FI12 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 |
Chain | Residue | Details |
E | LYS63 | |
F | LYS63 | |
G | LYS63 | |
H | LYS63 |