5DXR
Crystal Structure of the ER-alpha Ligand-binding Domain in Complex with the Cyclofenil Derivative 4,4'-{[(3R)-3-methylcyclohexylidene]methanediyl}diphenol
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue 5HW A 900 |
| Chain | Residue |
| A | LEU346 |
| A | HIS524 |
| A | LEU525 |
| A | LEU536 |
| A | LEU540 |
| A | HOH1027 |
| A | THR347 |
| A | ALA350 |
| A | GLU353 |
| A | LEU387 |
| A | MET388 |
| A | ARG394 |
| A | PHE404 |
| A | MET421 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue 5HW B 901 |
| Chain | Residue |
| B | LEU346 |
| B | THR347 |
| B | GLU353 |
| B | LEU387 |
| B | ARG394 |
| B | PHE404 |
| B | MET421 |
| B | LEU428 |
| B | HIS524 |
| B | LEU525 |
| B | LEU536 |
| B | LEU540 |
| B | HOH1022 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| C | SER699 | |
| D | SER699 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS447 | |
| B | CYS447 |
