5DWQ
Crystal structure of CARM1, sinefungin, and methylated H3 peptide (R17)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| A | 0018216 | biological_process | peptidyl-arginine methylation |
| B | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| B | 0018216 | biological_process | peptidyl-arginine methylation |
| C | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| C | 0018216 | biological_process | peptidyl-arginine methylation |
| D | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| D | 0018216 | biological_process | peptidyl-arginine methylation |
| F | 0000786 | cellular_component | nucleosome |
| F | 0003677 | molecular_function | DNA binding |
| F | 0030527 | molecular_function | structural constituent of chromatin |
| G | 0000786 | cellular_component | nucleosome |
| G | 0003677 | molecular_function | DNA binding |
| G | 0030527 | molecular_function | structural constituent of chromatin |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue SFG A 501 |
| Chain | Residue |
| A | TYR149 |
| A | GLU214 |
| A | ALA215 |
| A | LYS241 |
| A | VAL242 |
| A | GLU243 |
| A | GLU257 |
| A | MET268 |
| A | SER271 |
| A | HOH602 |
| A | HOH614 |
| A | PHE150 |
| A | HOH624 |
| A | HOH628 |
| A | HOH642 |
| A | TYR153 |
| A | GLN159 |
| A | MET162 |
| A | ARG168 |
| A | CYS193 |
| A | ILE197 |
| A | LEU198 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | binding site for residue GOL A 502 |
| Chain | Residue |
| A | HOH637 |
| site_id | AC3 |
| Number of Residues | 22 |
| Details | binding site for residue SFG B 501 |
| Chain | Residue |
| B | TYR149 |
| B | PHE150 |
| B | TYR153 |
| B | GLN159 |
| B | MET162 |
| B | ARG168 |
| B | CYS193 |
| B | ILE197 |
| B | LEU198 |
| B | GLU214 |
| B | ALA215 |
| B | LYS241 |
| B | VAL242 |
| B | GLU243 |
| B | GLU257 |
| B | MET268 |
| B | SER271 |
| B | HOH602 |
| B | HOH609 |
| B | HOH637 |
| B | HOH650 |
| F | NMM5 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 502 |
| Chain | Residue |
| A | GLN151 |
| B | GLN148 |
| B | ARG445 |
| B | LYS470 |
| B | HOH611 |
| F | LYS2 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | binding site for residue SFG C 501 |
| Chain | Residue |
| C | TYR149 |
| C | PHE150 |
| C | TYR153 |
| C | GLN159 |
| C | MET162 |
| C | ARG168 |
| C | CYS193 |
| C | ILE197 |
| C | GLU214 |
| C | ALA215 |
| C | LYS241 |
| C | VAL242 |
| C | GLU243 |
| C | GLU257 |
| C | MET268 |
| C | SER271 |
| C | HOH601 |
| C | HOH608 |
| C | HOH617 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue GOL C 503 |
| Chain | Residue |
| C | GLU266 |
| site_id | AC7 |
| Number of Residues | 21 |
| Details | binding site for residue SFG D 501 |
| Chain | Residue |
| D | TYR149 |
| D | TYR153 |
| D | GLN159 |
| D | MET162 |
| D | ARG168 |
| D | CYS193 |
| D | ILE197 |
| D | LEU198 |
| D | GLU214 |
| D | ALA215 |
| D | LYS241 |
| D | VAL242 |
| D | GLU243 |
| D | GLU257 |
| D | MET268 |
| D | SER271 |
| D | HOH608 |
| D | HOH611 |
| D | HOH613 |
| D | HOH640 |
| G | NMM5 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 D 502 |
| Chain | Residue |
| C | GLN151 |
| D | GLN148 |
| D | ARG445 |
| D | LYS470 |
| G | LYS2 |
| G | HOH102 |
Functional Information from PROSITE/UniProt
| site_id | PS00322 |
| Number of Residues | 7 |
| Details | HISTONE_H3_1 Histone H3 signature 1. KAPRKQL |
| Chain | Residue | Details |
| F | LYS2-LEU8 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435 |
| Chain | Residue | Details |
| D | GLY192 | |
| D | GLU214 | |
| D | GLU243 | |
| D | SER271 | |
| F | LYS2 | |
| G | LYS2 | |
| A | GLY192 | |
| A | GLU214 | |
| A | GLU243 | |
| A | SER271 | |
| B | GLN159 | |
| B | ARG168 | |
| B | GLY192 | |
| B | GLU214 | |
| B | GLU243 | |
| B | SER271 | |
| C | GLN159 | |
| C | ARG168 | |
| C | GLY192 | |
| C | GLU214 | |
| C | GLU243 | |
| C | SER271 | |
| D | GLN159 | |
| D | ARG168 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Citrulline; alternate => ECO:0000269|PubMed:15345777, ECO:0000269|PubMed:16497732, ECO:0000269|PubMed:16567635 |
| Chain | Residue | Details |
| F | NMM5 | |
| G | NMM5 | |
| C | SER216 | |
| D | SER216 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| B | LYS227 | |
| C | LYS227 | |
| D | LYS227 | |
| F | LYS6 | |
| G | LYS6 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| F | LYS11 | |
| G | LYS11 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Citrulline => ECO:0000269|PubMed:16567635 |
| Chain | Residue | Details |
| F | ARG14 | |
| G | ARG14 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:17194708, ECO:0000269|PubMed:7309716 |
| Chain | Residue | Details |
| F | LYS15 | |
| G | LYS15 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:15851689, ECO:0000269|PubMed:16185088 |
| Chain | Residue | Details |
| F | SER16 | |
| G | SER16 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | LIPID: N6-decanoyllysine => ECO:0000269|PubMed:35939806 |
| Chain | Residue | Details |
| F | LYS6 | |
| G | LYS6 |
