5DGI
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP and 3,5-(PCP)2-IP4
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000829 | molecular_function | inositol heptakisphosphate kinase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 23 |
Details | binding site for residue ADP A 401 |
Chain | Residue |
A | ARG134 |
A | MET240 |
A | ASP246 |
A | SER264 |
A | PRO265 |
A | ASP309 |
A | LEU311 |
A | CYS320 |
A | ASP321 |
A | MG403 |
A | MG404 |
A | PRO149 |
A | HOH519 |
A | HOH549 |
A | HOH694 |
A | HOH736 |
A | VAL185 |
A | LYS187 |
A | HIS194 |
A | LEU211 |
A | GLU237 |
A | GLU238 |
A | PHE239 |
site_id | AC2 |
Number of Residues | 22 |
Details | binding site for residue 5A2 A 402 |
Chain | Residue |
A | LYS53 |
A | LYS54 |
A | SER102 |
A | LYS103 |
A | ARG213 |
A | LYS214 |
A | TYR250 |
A | ARG262 |
A | ARG273 |
A | SER326 |
A | LYS329 |
A | HOH506 |
A | HOH512 |
A | HOH522 |
A | HOH557 |
A | HOH578 |
A | HOH589 |
A | HOH665 |
A | HOH703 |
A | HOH710 |
A | HOH743 |
A | HOH747 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue MG A 403 |
Chain | Residue |
A | ASP321 |
A | ASN323 |
A | ADP401 |
A | HOH515 |
A | HOH705 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue MG A 404 |
Chain | Residue |
A | ASP309 |
A | ASP321 |
A | ADP401 |
A | HOH549 |
A | HOH742 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue MG A 405 |
Chain | Residue |
A | SER68 |
A | PHE70 |
A | ILE73 |
A | HOH598 |
A | HOH653 |
A | HOH750 |
site_id | AC6 |
Number of Residues | 6 |
Details | binding site for residue ACT A 406 |
Chain | Residue |
A | VAL121 |
A | ASP124 |
A | LEU125 |
A | ASN126 |
A | HOH612 |
A | HOH658 |
site_id | AC7 |
Number of Residues | 7 |
Details | binding site for residue EDO A 407 |
Chain | Residue |
A | ASN90 |
A | TRP91 |
A | PRO92 |
A | PRO283 |
A | ILE285 |
A | HOH554 |
A | HOH741 |
site_id | AC8 |
Number of Residues | 6 |
Details | binding site for residue ACT A 408 |
Chain | Residue |
A | SER217 |
A | ARG218 |
A | LYS270 |
A | LYS291 |
A | LEU292 |
A | HOH542 |
site_id | AC9 |
Number of Residues | 8 |
Details | binding site for residue EDO A 409 |
Chain | Residue |
A | LYS248 |
A | TYR250 |
A | GLY307 |
A | PHE308 |
A | ASP309 |
A | ASN323 |
A | SER326 |
A | HOH522 |
site_id | AD1 |
Number of Residues | 7 |
Details | binding site for residue EDO A 410 |
Chain | Residue |
A | ARG312 |
A | ALA313 |
A | GLY315 |
A | GLN316 |
A | SER317 |
A | HOH518 |
A | HOH527 |
site_id | AD2 |
Number of Residues | 7 |
Details | binding site for residue EDO A 411 |
Chain | Residue |
A | LYS333 |
A | TYR334 |
A | HOH737 |
A | GLU89 |
A | ASN90 |
A | TYR256 |
A | HIS258 |
site_id | AD3 |
Number of Residues | 2 |
Details | binding site for residue ACT A 412 |
Chain | Residue |
A | PHE70 |
A | HOH656 |
site_id | AD4 |
Number of Residues | 6 |
Details | binding site for residue EDO A 413 |
Chain | Residue |
A | PHE105 |
A | PRO106 |
A | LEU107 |
A | ASP108 |
A | HOH501 |
A | HOH607 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22119861, ECO:0007744|PDB:3T9C, ECO:0007744|PDB:3T9D, ECO:0007744|PDB:3T9E, ECO:0007744|PDB:3T9F |
Chain | Residue | Details |
A | LYS53 | |
A | LYS248 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22119861, ECO:0007744|PDB:3T54, ECO:0007744|PDB:3T7A, ECO:0007744|PDB:3T99, ECO:0007744|PDB:3T9A, ECO:0007744|PDB:3T9B, ECO:0007744|PDB:3T9C, ECO:0007744|PDB:3T9D, ECO:0007744|PDB:3T9E, ECO:0007744|PDB:3T9F |
Chain | Residue | Details |
A | ARG134 | |
A | LYS187 | |
A | HIS194 | |
A | GLU237 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22119861, ECO:0007744|PDB:3T9A, ECO:0007744|PDB:3T9B, ECO:0007744|PDB:3T9C, ECO:0007744|PDB:3T9D |
Chain | Residue | Details |
A | ARG213 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22119861, ECO:0007744|PDB:3T54, ECO:0007744|PDB:3T9A, ECO:0007744|PDB:3T9B, ECO:0007744|PDB:3T9C, ECO:0007744|PDB:3T9D |
Chain | Residue | Details |
A | ASP246 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22119861, ECO:0007744|PDB:3T9C, ECO:0007744|PDB:3T9E, ECO:0007744|PDB:3T9F |
Chain | Residue | Details |
A | ARG262 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22119861, ECO:0007744|PDB:3T54, ECO:0007744|PDB:3T7A |
Chain | Residue | Details |
A | SER264 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22119861, ECO:0007744|PDB:3T54, ECO:0007744|PDB:3T7A, ECO:0007744|PDB:3T99, ECO:0007744|PDB:3T9B, ECO:0007744|PDB:3T9C, ECO:0007744|PDB:3T9D, ECO:0007744|PDB:3T9E, ECO:0007744|PDB:3T9F |
Chain | Residue | Details |
A | ASP309 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22119861, ECO:0007744|PDB:3T54 |
Chain | Residue | Details |
A | ASP321 |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22119861, ECO:0007744|PDB:3T9D, ECO:0007744|PDB:3T9E |
Chain | Residue | Details |
A | SER326 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER223 |