5DAD

Crystal Structure of Human KEAP1 BTB Domain in Complex with Small Molecule TX64014

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008134	molecular_function	transcription factor binding
A	0016567	biological_process	protein ubiquitination
A	0031463	cellular_component	Cul3-RING ubiquitin ligase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue TX6 A 201

Chain	Residue
A	TYR85
A	HIS129
A	VAL132
A	MET147
A	GLY148
A	LYS150
A	CYS151
A	HIS154

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Sensor for electrophilic agents => ECO:0000269|PubMed:18251510, ECO:0000269|PubMed:29590092

Chain	Residue	Details
A	CYS151

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: S-nitrosocysteine; alternate => ECO:0000250|UniProtKB:Q9Z2X8

Chain	Residue	Details
A	CYS151

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site_id	SWS_FT_FI3
Number of Residues	1
Details	CROSSLNK: N5-[4-(S-L-cysteinyl)-5-methyl-1H-imidazol-2-yl]-L-ornithine (Arg-Cys) (interchain with C-151 in KEAP1) => ECO:0000269|PubMed:30323285

Chain	Residue	Details
A	ARG135

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CROSSLNK: N5-[4-(S-L-cysteinyl)-5-methyl-1H-imidazol-2-yl]-L-ornithine (Cys-Arg) (interchain with R-135 in KEAP1) => ECO:0000269|PubMed:30323285

Chain	Residue	Details
A	CYS151

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