5CGA
Structure of Hydroxyethylthiazole kinase ThiM from Staphylococcus aureus in complex with substrate analog 2-(1,3,5-trimethyl-1H-pyrazole-4-yl)ethanol
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0004417 | molecular_function | hydroxyethylthiazole kinase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0009228 | biological_process | thiamine biosynthetic process |
A | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
A | 0016301 | molecular_function | kinase activity |
A | 0046872 | molecular_function | metal ion binding |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0004417 | molecular_function | hydroxyethylthiazole kinase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0009228 | biological_process | thiamine biosynthetic process |
B | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
B | 0016301 | molecular_function | kinase activity |
B | 0046872 | molecular_function | metal ion binding |
C | 0000287 | molecular_function | magnesium ion binding |
C | 0004417 | molecular_function | hydroxyethylthiazole kinase activity |
C | 0005524 | molecular_function | ATP binding |
C | 0009228 | biological_process | thiamine biosynthetic process |
C | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
C | 0016301 | molecular_function | kinase activity |
C | 0046872 | molecular_function | metal ion binding |
E | 0000287 | molecular_function | magnesium ion binding |
E | 0004417 | molecular_function | hydroxyethylthiazole kinase activity |
E | 0005524 | molecular_function | ATP binding |
E | 0009228 | biological_process | thiamine biosynthetic process |
E | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
E | 0016301 | molecular_function | kinase activity |
E | 0046872 | molecular_function | metal ion binding |
F | 0000287 | molecular_function | magnesium ion binding |
F | 0004417 | molecular_function | hydroxyethylthiazole kinase activity |
F | 0005524 | molecular_function | ATP binding |
F | 0009228 | biological_process | thiamine biosynthetic process |
F | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
F | 0016301 | molecular_function | kinase activity |
F | 0046872 | molecular_function | metal ion binding |
H | 0000287 | molecular_function | magnesium ion binding |
H | 0004417 | molecular_function | hydroxyethylthiazole kinase activity |
H | 0005524 | molecular_function | ATP binding |
H | 0009228 | biological_process | thiamine biosynthetic process |
H | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
H | 0016301 | molecular_function | kinase activity |
H | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | binding site for residue KP6 A 301 |
Chain | Residue |
A | ASN19 |
A | GLY61 |
A | THR186 |
A | GLY187 |
A | CYS190 |
B | PRO37 |
B | ALA38 |
B | MET39 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue MG A 302 |
Chain | Residue |
A | GLY116 |
A | GLU120 |
A | HOH404 |
A | HOH413 |
A | ASP88 |
site_id | AC3 |
Number of Residues | 8 |
Details | binding site for residue KP6 B 301 |
Chain | Residue |
B | ASN19 |
B | GLY61 |
B | VAL90 |
B | THR186 |
B | GLY187 |
C | PRO37 |
C | ALA38 |
C | MET39 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue MG B 302 |
Chain | Residue |
B | ASP88 |
B | GLY116 |
B | GLU120 |
B | HOH418 |
site_id | AC5 |
Number of Residues | 9 |
Details | binding site for residue KP6 C 301 |
Chain | Residue |
A | PRO37 |
A | ALA38 |
A | MET39 |
C | ASN19 |
C | GLY61 |
C | THR186 |
C | GLY187 |
C | CYS190 |
C | HOH429 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue MG C 302 |
Chain | Residue |
C | ASP88 |
C | GLY116 |
C | GLU120 |
C | HOH412 |
site_id | AC7 |
Number of Residues | 7 |
Details | binding site for residue KP6 E 301 |
Chain | Residue |
E | ASN19 |
E | GLY61 |
E | THR186 |
E | GLY187 |
F | PRO37 |
F | ALA38 |
F | MET39 |
site_id | AC8 |
Number of Residues | 3 |
Details | binding site for residue MG E 302 |
Chain | Residue |
E | ASP88 |
E | GLU120 |
E | HOH441 |
site_id | AC9 |
Number of Residues | 8 |
Details | binding site for residue KP6 F 301 |
Chain | Residue |
F | ASN19 |
F | GLY61 |
F | THR186 |
F | GLY187 |
F | HOH401 |
H | PRO37 |
H | ALA38 |
H | MET39 |
site_id | AD1 |
Number of Residues | 7 |
Details | binding site for residue KP6 H 301 |
Chain | Residue |
E | PRO37 |
E | ALA38 |
E | MET39 |
H | ASN19 |
H | GLY61 |
H | THR186 |
H | GLY187 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 24 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00228 |
Chain | Residue | Details |
E | MET39 | |
E | LYS115 | |
E | THR160 | |
E | GLY187 | |
F | MET39 | |
F | LYS115 | |
F | THR160 | |
F | GLY187 | |
H | MET39 | |
H | LYS115 | |
H | THR160 | |
H | GLY187 | |
A | MET39 | |
A | LYS115 | |
A | THR160 | |
A | GLY187 | |
B | LYS115 | |
B | THR160 | |
B | GLY187 | |
C | MET39 | |
C | LYS115 | |
C | THR160 | |
C | GLY187 | |
B | MET39 |