5BNM
E. coli FabH with Small Molecule Inhibitor 1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0033818 | molecular_function | beta-ketoacyl-acyl-carrier-protein synthase III activity |
| A | 0044281 | biological_process | small molecule metabolic process |
| B | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0033818 | molecular_function | beta-ketoacyl-acyl-carrier-protein synthase III activity |
| B | 0044281 | biological_process | small molecule metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 401 |
| Chain | Residue |
| A | LYS4 |
| A | GLU170 |
| A | GLU171 |
| A | HOH548 |
| A | HOH727 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue 4VK A 402 |
| Chain | Residue |
| A | ILE156 |
| A | GLY209 |
| A | VAL212 |
| A | ALA216 |
| A | HIS244 |
| A | ALA246 |
| A | ASN247 |
| A | ARG249 |
| A | ILE250 |
| A | ASN274 |
| A | PHE304 |
| A | TRP32 |
| A | ARG36 |
| A | THR37 |
| A | CYS112 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue PG4 B 401 |
| Chain | Residue |
| B | ARG36 |
| B | CYS112 |
| B | VAL212 |
| B | HIS244 |
| B | ALA246 |
| B | ASN247 |
| B | ASN274 |
| B | PHE304 |
| B | HOH606 |
| B | HOH712 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01815, ECO:0000305|PubMed:10593943, ECO:0000305|PubMed:10673437, ECO:0000305|PubMed:11243824 |
| Chain | Residue | Details |
| A | CYS112 | |
| A | HIS244 | |
| A | ASN274 | |
| B | CYS112 | |
| B | HIS244 | |
| B | ASN274 |
