5AC7
S. enterica HisA with mutations D7N, D10G, dup13-15
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000105 | biological_process | histidine biosynthetic process |
| A | 0000162 | biological_process | tryptophan biosynthetic process |
| A | 0003949 | molecular_function | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0016853 | molecular_function | isomerase activity |
| B | 0000105 | biological_process | histidine biosynthetic process |
| B | 0000162 | biological_process | tryptophan biosynthetic process |
| B | 0003949 | molecular_function | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0016853 | molecular_function | isomerase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 1245 |
| Chain | Residue |
| A | ARG193 |
| B | ARG193 |
| B | TYR194 |
| B | PRO195 |
| B | GLN196 |
| B | HOH2058 |
| B | HOH2082 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 1244 |
| Chain | Residue |
| A | PRO195 |
| A | GLN196 |
| A | HOH2100 |
| A | HOH2120 |
| B | ARG193 |
| A | ARG193 |
| A | TYR194 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 1245 |
| Chain | Residue |
| A | MET1 |
| A | ILE2 |
| A | GLN243 |
| A | HOH2001 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1246 |
| Chain | Residue |
| B | GLY177 |
| B | GLY203 |
| B | GLY225 |
| B | ARG226 |
| B | HOH2068 |
| B | HOH2086 |
| B | HOH2087 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1246 |
| Chain | Residue |
| A | ASP176 |
| A | GLY177 |
| A | GLY203 |
| A | GLY204 |
| A | GLY225 |
| A | ARG226 |
| A | HOH2106 |
| A | HOH2124 |
| A | HOH2125 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1247 |
| Chain | Residue |
| A | ARG131 |
| A | TRP145 |
| A | SER174 |
| B | ARG15 |
| B | ARG25 |
| B | GLU230 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000250 |
| Chain | Residue | Details |
| A | ASN7 | |
| B | ASN7 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP129 | |
| B | ASP129 |
