5AB0

Crystal structure of aminopeptidase ERAP2 with ligand

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002250	biological_process	adaptive immune response
A	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
A	0004175	molecular_function	endopeptidase activity
A	0004177	molecular_function	aminopeptidase activity
A	0005515	molecular_function	protein binding
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006508	biological_process	proteolysis
A	0008217	biological_process	regulation of blood pressure
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0016020	cellular_component	membrane
A	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
A	0042277	molecular_function	peptide binding
A	0043171	biological_process	peptide catabolic process
A	0046872	molecular_function	metal ion binding
A	0070006	molecular_function	metalloaminopeptidase activity
C	0002250	biological_process	adaptive immune response
C	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
C	0004175	molecular_function	endopeptidase activity
C	0004177	molecular_function	aminopeptidase activity
C	0005515	molecular_function	protein binding
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0005783	cellular_component	endoplasmic reticulum
C	0005788	cellular_component	endoplasmic reticulum lumen
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0006508	biological_process	proteolysis
C	0008217	biological_process	regulation of blood pressure
C	0008237	molecular_function	metallopeptidase activity
C	0008270	molecular_function	zinc ion binding
C	0016020	cellular_component	membrane
C	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
C	0042277	molecular_function	peptide binding
C	0043171	biological_process	peptide catabolic process
C	0046872	molecular_function	metal ion binding
C	0070006	molecular_function	metalloaminopeptidase activity

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VIAHELAHQW

Chain	Residue	Details
A	VAL367-TRP376

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	38
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	MET1-ARG20
C	MET1-ARG20

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site_id	SWS_FT_FI2
Number of Residues	38
Details	TRANSMEM: Helical; Signal-anchor for type II membrane protein => ECO:0000255

Chain	Residue	Details
A	GLY21-VAL40
C	GLY21-VAL40

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site_id	SWS_FT_FI3
Number of Residues	1838
Details	TOPO_DOM: Lumenal => ECO:0000255

Chain	Residue	Details
A	PRO41-THR960
C	PRO41-THR960

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site_id	SWS_FT_FI4
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:22106953

Chain	Residue	Details
A	GLU371
C	GLU371

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:22106953

Chain	Residue	Details
A	GLU200
C	GLU200

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site_id	SWS_FT_FI6
Number of Residues	8
Details	BINDING:

Chain	Residue	Details
A	GLY334
A	HIS370
A	HIS374
A	GLU393
C	GLY334
C	HIS370
C	HIS374
C	GLU393

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site_id	SWS_FT_FI7
Number of Residues	2
Details	SITE: Transition state stabilizer

Chain	Residue	Details
A	TYR455
C	TYR455

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site_id	SWS_FT_FI8
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22106953

Chain	Residue	Details
A	ASN85
A	ASN219
A	ASN405
A	ASN650
C	ASN85
C	ASN219
C	ASN405
C	ASN650

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site_id	SWS_FT_FI9
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952

Chain	Residue	Details
A	ASN119
C	ASN119

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