4ZYT

Human GAR transformylase in complex with GAR and N-{4-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)benzyl]benzoyl}-L-glutamic acid (AGF23)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004644	molecular_function	phosphoribosylglycinamide formyltransferase activity
A	0006189	biological_process	'de novo' IMP biosynthetic process
A	0009058	biological_process	biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	binding site for residue GAR A 1101

Chain	Residue
A	THR817
A	LYS977
A	GLU980
A	3Y91102
A	HOH1217
A	HOH1224
A	HOH1226
A	HOH1228
A	HOH1238
A	HOH1252
A	HOH1277
A	GLY818
A	HOH1304
A	SER819
A	ASN820
A	GLY894
A	MET896
A	HIS915
A	PRO916
A	GLY924

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site_id	AC2
Number of Residues	19
Details	binding site for residue 3Y9 A 1102

Chain	Residue
A	LYS844
A	HIS865
A	ARG871
A	PHE895
A	MET896
A	ARG897
A	ILE898
A	LEU899
A	VAL904
A	HIS944
A	VAL946
A	ALA947
A	GLU948
A	VAL950
A	ASP951
A	GAR1101
A	HOH1217
A	HOH1233
A	HOH1300

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Functional Information from PROSITE/UniProt

site_id	PS00373
Number of Residues	24
Details	GART Phosphoribosylglycinamide formyltransferase active site. GcTVhFVaEdVDaGqiIlqeavpV

Chain	Residue	Details
A	GLY940-VAL963

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000250|UniProtKB:P08179

Chain	Residue	Details
A	HIS915

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:12450384, ECO:0000269|PubMed:16026156, ECO:0007744|PDB:1MEN, ECO:0007744|PDB:1ZLY

Chain	Residue	Details
A	GLY818
A	LYS977

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305|PubMed:12755606, ECO:0007744|PDB:1NJS

Chain	Residue	Details
A	ASN913
A	ARG871

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site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305|PubMed:12755606, ECO:0000305|PubMed:16026156, ECO:0007744|PDB:1NJS, ECO:0007744|PDB:1ZLY

Chain	Residue	Details
A	MET896
A	ALA947

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Raises pKa of active site His => ECO:0000250|UniProtKB:P08179

Chain	Residue	Details
A	ASP951

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