4Y7G
Crystal structure of glucosyl-3-phosphoglycerate synthase from Mycobacterium tuberculosis in complex with Mn2+, uridine-diphosphate-glucose (UDP-Glc) and glycerol 3-phosphate (G3P) - GpgS Mn2+ UDP-Glc G3P
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0006011 | biological_process | UDP-glucose metabolic process |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0016758 | molecular_function | hexosyltransferase activity |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 401 |
| Chain | Residue |
| A | ASP136 |
| A | HIS258 |
| A | UPG403 |
| A | HOH510 |
| A | HOH511 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue G3P A 402 |
| Chain | Residue |
| A | HIS258 |
| A | ASN260 |
| A | HOH513 |
| A | GLY184 |
| A | ARG185 |
| A | THR187 |
| A | ARG256 |
| site_id | AC3 |
| Number of Residues | 23 |
| Details | binding site for residue UPG A 403 |
| Chain | Residue |
| A | PRO50 |
| A | ALA51 |
| A | LEU52 |
| A | GLU54 |
| A | SER81 |
| A | GLY113 |
| A | LYS114 |
| A | ASP134 |
| A | SER135 |
| A | ASP136 |
| A | LEU209 |
| A | GLY211 |
| A | TYR229 |
| A | GLU232 |
| A | ARG256 |
| A | HIS258 |
| A | ARG259 |
| A | ARG261 |
| A | MET269 |
| A | MN401 |
| A | HOH511 |
| A | HOH512 |
| A | HOH525 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26136334, ECO:0007744|PDB:4Y6N, ECO:0007744|PDB:4Y6U, ECO:0007744|PDB:4Y7F, ECO:0007744|PDB:4Y7G, ECO:0007744|PDB:4Y9X |
| Chain | Residue | Details |
| A | LYS114 | |
| A | ASP134 | |
| A | ASP136 | |
| A | TYR229 | |
| A | HIS258 | |
| A | PRO50 | |
| A | SER81 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26136334, ECO:0000269|PubMed:28625787, ECO:0007744|PDB:4Y6N, ECO:0007744|PDB:4Y6U, ECO:0007744|PDB:4Y9X, ECO:0007744|PDB:5JQX |
| Chain | Residue | Details |
| A | GLY184 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:28625787, ECO:0007744|PDB:5JT0 |
| Chain | Residue | Details |
| A | ARG256 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26136334, ECO:0007744|PDB:4Y6N, ECO:0007744|PDB:4Y6U |
| Chain | Residue | Details |
| A | ASN260 |
