4XGS
Crystal structure analysis of novel iron uptake mechanism of Gram-negative bacterial ferritin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004322 | molecular_function | ferroxidase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006826 | biological_process | iron ion transport |
| A | 0006879 | biological_process | intracellular iron ion homeostasis |
| A | 0006880 | biological_process | intracellular sequestering of iron ion |
| A | 0006974 | biological_process | DNA damage response |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0008198 | molecular_function | ferrous iron binding |
| A | 0008199 | molecular_function | ferric iron binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0071281 | biological_process | cellular response to iron ion |
| A | 0140315 | molecular_function | iron ion sequestering activity |
| B | 0004322 | molecular_function | ferroxidase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006826 | biological_process | iron ion transport |
| B | 0006879 | biological_process | intracellular iron ion homeostasis |
| B | 0006880 | biological_process | intracellular sequestering of iron ion |
| B | 0006974 | biological_process | DNA damage response |
| B | 0006979 | biological_process | response to oxidative stress |
| B | 0008198 | molecular_function | ferrous iron binding |
| B | 0008199 | molecular_function | ferric iron binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0071281 | biological_process | cellular response to iron ion |
| B | 0140315 | molecular_function | iron ion sequestering activity |
| C | 0004322 | molecular_function | ferroxidase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006826 | biological_process | iron ion transport |
| C | 0006879 | biological_process | intracellular iron ion homeostasis |
| C | 0006880 | biological_process | intracellular sequestering of iron ion |
| C | 0006974 | biological_process | DNA damage response |
| C | 0006979 | biological_process | response to oxidative stress |
| C | 0008198 | molecular_function | ferrous iron binding |
| C | 0008199 | molecular_function | ferric iron binding |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0071281 | biological_process | cellular response to iron ion |
| C | 0140315 | molecular_function | iron ion sequestering activity |
| D | 0004322 | molecular_function | ferroxidase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006826 | biological_process | iron ion transport |
| D | 0006879 | biological_process | intracellular iron ion homeostasis |
| D | 0006880 | biological_process | intracellular sequestering of iron ion |
| D | 0006974 | biological_process | DNA damage response |
| D | 0006979 | biological_process | response to oxidative stress |
| D | 0008198 | molecular_function | ferrous iron binding |
| D | 0008199 | molecular_function | ferric iron binding |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0071281 | biological_process | cellular response to iron ion |
| D | 0140315 | molecular_function | iron ion sequestering activity |
| E | 0004322 | molecular_function | ferroxidase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0006826 | biological_process | iron ion transport |
| E | 0006879 | biological_process | intracellular iron ion homeostasis |
| E | 0006880 | biological_process | intracellular sequestering of iron ion |
| E | 0006974 | biological_process | DNA damage response |
| E | 0006979 | biological_process | response to oxidative stress |
| E | 0008198 | molecular_function | ferrous iron binding |
| E | 0008199 | molecular_function | ferric iron binding |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0071281 | biological_process | cellular response to iron ion |
| E | 0140315 | molecular_function | iron ion sequestering activity |
| F | 0004322 | molecular_function | ferroxidase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0006826 | biological_process | iron ion transport |
| F | 0006879 | biological_process | intracellular iron ion homeostasis |
| F | 0006880 | biological_process | intracellular sequestering of iron ion |
| F | 0006974 | biological_process | DNA damage response |
| F | 0006979 | biological_process | response to oxidative stress |
| F | 0008198 | molecular_function | ferrous iron binding |
| F | 0008199 | molecular_function | ferric iron binding |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0071281 | biological_process | cellular response to iron ion |
| F | 0140315 | molecular_function | iron ion sequestering activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue OFO A 201 |
| Chain | Residue |
| A | GLU17 |
| A | GLU50 |
| A | HIS53 |
| A | GLU94 |
| A | TYR123 |
| A | GLN127 |
| A | GLU130 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 202 |
| Chain | Residue |
| A | THR72 |
| A | HOH357 |
| D | GLN112 |
| A | ARG69 |
| A | ASN71 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 203 |
| Chain | Residue |
| A | SER21 |
| A | LEU22 |
| A | GLN25 |
| A | ALA47 |
| A | GLN48 |
| A | MET51 |
| A | HOH344 |
| F | MET54 |
| F | GLN55 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 204 |
| Chain | Residue |
| A | ARG56 |
| A | ASP59 |
| A | TYR60 |
| A | ASP63 |
| A | PHE119 |
| A | GOL206 |
| F | HIS128 |
| F | GLU129 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 205 |
| Chain | Residue |
| A | SER82 |
| A | LEU83 |
| A | ASP84 |
| A | GLY145 |
| A | LEU151 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 206 |
| Chain | Residue |
| A | ARG56 |
| A | TYR60 |
| A | PRO115 |
| A | ASN118 |
| A | PHE119 |
| A | GOL204 |
| F | SER125 |
| F | HIS128 |
| F | HOH322 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue OFO B 201 |
| Chain | Residue |
| B | GLU17 |
| B | GLU50 |
| B | HIS53 |
| B | GLU94 |
| B | TYR123 |
| B | GLN127 |
| B | GLU130 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 202 |
| Chain | Residue |
| B | SER21 |
| B | LEU22 |
| B | GLN25 |
| B | ALA47 |
| B | GLN48 |
| B | MET51 |
| B | HOH347 |
| E | MET51 |
| E | GLN55 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 203 |
| Chain | Residue |
| B | PRO115 |
| B | ASN118 |
| B | PHE119 |
| B | HOH301 |
| E | SER125 |
| E | HIS128 |
| E | GOL205 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue OFO C 201 |
| Chain | Residue |
| C | GLU17 |
| C | GLU50 |
| C | HIS53 |
| C | GLU94 |
| C | ILE97 |
| C | TYR123 |
| C | GLN127 |
| C | GLU130 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 C 202 |
| Chain | Residue |
| C | ARG69 |
| C | ASN71 |
| C | THR72 |
| D | SER75 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL C 203 |
| Chain | Residue |
| C | SER21 |
| C | LEU22 |
| C | GLN25 |
| C | ALA47 |
| C | GLN48 |
| C | MET51 |
| D | MET54 |
| D | GLN55 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 204 |
| Chain | Residue |
| C | ASN15 |
| C | ASN71 |
| C | THR72 |
| C | GLU74 |
| C | HOH350 |
| site_id | AD5 |
| Number of Residues | 8 |
| Details | binding site for residue GOL C 205 |
| Chain | Residue |
| A | HIS128 |
| A | GLU129 |
| C | ARG56 |
| C | ASP59 |
| C | TYR60 |
| C | ASP63 |
| C | PHE119 |
| C | GOL206 |
| site_id | AD6 |
| Number of Residues | 8 |
| Details | binding site for residue GOL C 206 |
| Chain | Residue |
| A | SER125 |
| A | HIS128 |
| A | HOH340 |
| C | TYR60 |
| C | PRO115 |
| C | ASN118 |
| C | PHE119 |
| C | GOL205 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue OFO D 201 |
| Chain | Residue |
| D | GLU17 |
| D | GLU50 |
| D | HIS53 |
| D | GLU94 |
| D | TYR123 |
| D | GLN127 |
| D | GLU130 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 D 202 |
| Chain | Residue |
| D | GLU49 |
| D | GLU126 |
| D | GLU130 |
| D | ASP162 |
| site_id | AD9 |
| Number of Residues | 9 |
| Details | binding site for residue GOL D 203 |
| Chain | Residue |
| C | MET54 |
| C | GLN55 |
| D | SER21 |
| D | LEU22 |
| D | GLN25 |
| D | ALA47 |
| D | GLN48 |
| D | MET51 |
| D | HOH330 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL D 204 |
| Chain | Residue |
| A | SER136 |
| A | ASP139 |
| A | LYS140 |
| D | THR35 |
| D | GLU37 |
| site_id | AE2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL D 205 |
| Chain | Residue |
| B | HIS128 |
| B | GLU129 |
| B | LYS132 |
| D | ARG56 |
| D | ASP63 |
| D | PHE119 |
| D | GOL206 |
| site_id | AE3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL D 206 |
| Chain | Residue |
| B | SER125 |
| B | HOH323 |
| D | PRO115 |
| D | ASN118 |
| D | GOL205 |
| D | HOH322 |
| D | HOH351 |
| site_id | AE4 |
| Number of Residues | 7 |
| Details | binding site for residue OFO E 201 |
| Chain | Residue |
| E | GLU17 |
| E | GLU50 |
| E | HIS53 |
| E | GLU94 |
| E | TYR123 |
| E | GLN127 |
| E | GLU130 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 E 202 |
| Chain | Residue |
| A | GLN112 |
| A | HOH333 |
| E | ARG69 |
| E | ASN71 |
| E | THR72 |
| site_id | AE6 |
| Number of Residues | 8 |
| Details | binding site for residue GOL E 203 |
| Chain | Residue |
| B | MET54 |
| B | GLN55 |
| E | SER21 |
| E | LEU22 |
| E | GLN25 |
| E | GLN48 |
| E | MET51 |
| E | HOH350 |
| site_id | AE7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL E 204 |
| Chain | Residue |
| D | ASN102 |
| E | HIS1 |
| E | LEU2 |
| E | ASP113 |
| E | PRO115 |
| E | HOH341 |
| E | HOH348 |
| site_id | AE8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL E 205 |
| Chain | Residue |
| B | ARG56 |
| B | TYR60 |
| B | PHE119 |
| B | GOL203 |
| E | HIS128 |
| site_id | AE9 |
| Number of Residues | 7 |
| Details | binding site for residue OFO F 201 |
| Chain | Residue |
| F | GLU17 |
| F | GLU50 |
| F | HIS53 |
| F | GLU94 |
| F | TYR123 |
| F | GLN127 |
| F | GLU130 |
| site_id | AF1 |
| Number of Residues | 9 |
| Details | binding site for residue GOL F 202 |
| Chain | Residue |
| A | MET54 |
| A | GLN55 |
| F | SER21 |
| F | LEU22 |
| F | GLN25 |
| F | ALA47 |
| F | GLN48 |
| F | MET51 |
| F | HOH324 |
| site_id | AF2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL F 203 |
| Chain | Residue |
| C | HOH379 |
| F | HIS1 |
| F | LEU2 |
| F | ASN111 |
| F | ASP113 |
| F | HOH336 |
| site_id | AF3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL F 204 |
| Chain | Residue |
| C | HIS128 |
| F | PRO115 |
| F | ASN118 |
| F | GOL205 |
| site_id | AF4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL F 205 |
| Chain | Residue |
| F | ASN118 |
| F | PHE119 |
| F | GLN121 |
| F | TRP122 |
| F | GOL204 |
| site_id | AF5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL F 206 |
| Chain | Residue |
| A | LEU2 |
| A | PRO115 |
| F | HIS128 |
| F | GLU131 |
| F | HOH333 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 48 |
| Details | BINDING: |
| Chain | Residue | Details |
| B | GLU94 | |
| B | GLU126 | |
| B | GLN127 | |
| B | GLU130 | |
| C | GLU17 | |
| C | GLU49 | |
| C | GLU50 | |
| C | HIS53 | |
| C | GLU94 | |
| C | GLU126 | |
| C | GLN127 | |
| C | GLU130 | |
| D | GLU17 | |
| D | GLU49 | |
| D | GLU50 | |
| D | HIS53 | |
| D | GLU94 | |
| D | GLU126 | |
| D | GLN127 | |
| D | GLU130 | |
| E | GLU17 | |
| E | GLU49 | |
| E | GLU50 | |
| E | HIS53 | |
| E | GLU94 | |
| E | GLU126 | |
| E | GLN127 | |
| E | GLU130 | |
| F | GLU17 | |
| F | GLU49 | |
| F | GLU50 | |
| F | HIS53 | |
| F | GLU94 | |
| F | GLU126 | |
| F | GLN127 | |
| F | GLU130 | |
| A | GLU17 | |
| A | GLU49 | |
| A | GLU50 | |
| A | HIS53 | |
| A | GLU94 | |
| A | GLU126 | |
| A | GLN127 | |
| A | GLU130 | |
| B | GLU17 | |
| B | GLU49 | |
| B | GLU50 | |
| B | HIS53 |
