4X9P
Crystal structure of bovine Annexin A2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001786 | molecular_function | phosphatidylserine binding |
| A | 0002020 | molecular_function | protease binding |
| A | 0004859 | molecular_function | phospholipase inhibitor activity |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005544 | molecular_function | calcium-dependent phospholipid binding |
| A | 0005546 | molecular_function | phosphatidylinositol-4,5-bisphosphate binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005604 | cellular_component | basement membrane |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005768 | cellular_component | endosome |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008092 | molecular_function | cytoskeletal protein binding |
| A | 0016020 | cellular_component | membrane |
| A | 0019834 | molecular_function | phospholipase A2 inhibitor activity |
| A | 0031214 | biological_process | biomineral tissue development |
| A | 0031982 | cellular_component | vesicle |
| A | 0042470 | cellular_component | melanosome |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0046790 | molecular_function | virion binding |
| A | 0062023 | cellular_component | collagen-containing extracellular matrix |
| A | 0065010 | cellular_component | extracellular membrane-bounded organelle |
| A | 0070509 | biological_process | calcium ion import |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0098641 | molecular_function | cadherin binding involved in cell-cell adhesion |
| A | 1905602 | biological_process | positive regulation of receptor-mediated endocytosis involved in cholesterol transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 401 |
| Chain | Residue |
| A | SER234 |
| A | MET278 |
| A | GLY280 |
| A | GLY282 |
| A | ASP322 |
| A | HOH567 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 402 |
| Chain | Residue |
| A | GLY207 |
| A | GLU247 |
| A | HOH749 |
| A | GLY202 |
| A | ARG205 |
| A | LYS206 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue CA A 403 |
| Chain | Residue |
| A | GLY50 |
| A | VAL51 |
| A | GLU53 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 404 |
| Chain | Residue |
| A | HIS94 |
| A | ARG178 |
Functional Information from PROSITE/UniProt
| site_id | PS00223 |
| Number of Residues | 53 |
| Details | ANNEXIN_1 Annexin repeat signature. GVdevtivniLtnRsneQrqDiafaYqrrtkkeLasaLksalsGhletvIlgL |
| Chain | Residue | Details |
| A | GLY50-LEU102 | |
| A | GLY122-LEU174 | |
| A | GLY207-LEU259 | |
| A | GLY282-LEU334 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylserine => ECO:0000269|PubMed:2942542 |
| Chain | Residue | Details |
| A | SER2 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine; by SRC => ECO:0000250|UniProtKB:P07355 |
| Chain | Residue | Details |
| A | TYR24 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKC => ECO:0000250|UniProtKB:P07355 |
| Chain | Residue | Details |
| A | SER26 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P07356 |
| Chain | Residue | Details |
| A | LYS49 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P07356 |
| Chain | Residue | Details |
| A | LYS152 | |
| A | LYS227 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P07355 |
| Chain | Residue | Details |
| A | SER184 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P07356 |
| Chain | Residue | Details |
| A | TYR199 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:P07355 |
| Chain | Residue | Details |
| A | LYS49 |
