4X5A
Anthranilate phosphoribosyltransferase variant R193A from Mycobacterium tuberculosis remains ligand-free when co-crystallised with PRPP and Mg
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000162 | biological_process | tryptophan biosynthetic process |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004048 | molecular_function | anthranilate phosphoribosyltransferase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000162 | biological_process | tryptophan biosynthetic process |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004048 | molecular_function | anthranilate phosphoribosyltransferase activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 401 |
| Chain | Residue |
| A | ARG237 |
| A | ARG238 |
| A | LEU305 |
| A | GLY306 |
| A | ILE351 |
| A | ASP352 |
| A | GLU357 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 402 |
| Chain | Residue |
| A | ALA355 |
| A | ARG362 |
| A | HOH503 |
| A | HOH505 |
| A | HOH513 |
| A | ARG42 |
| A | ALA128 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 401 |
| Chain | Residue |
| B | ASP159 |
| B | PRO180 |
| B | ARG181 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 402 |
| Chain | Residue |
| B | THR273 |
| B | PHE274 |
| B | ASP275 |
| B | TRP336 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 403 |
| Chain | Residue |
| B | ALA236 |
| B | ARG237 |
| B | ARG238 |
| B | LEU305 |
| B | GLY306 |
| B | GLY307 |
| B | ILE351 |
| B | ASP352 |
| B | GLU357 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00211 |
| Chain | Residue | Details |
| A | GLY107 | |
| B | GLY107 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | GLY110 | |
| B | ASN117 | |
| B | SER119 | |
| B | LYS135 | |
| B | ASN138 | |
| B | ALA193 | |
| B | ASP251 | |
| B | GLU252 | |
| A | ASN117 | |
| A | SER119 | |
| A | LYS135 | |
| A | ASN138 | |
| A | ALA193 | |
| A | ASP251 | |
| A | GLU252 | |
| B | GLY110 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00211, ECO:0000269|PubMed:16337227, ECO:0000269|PubMed:23363292, ECO:0000269|Ref.4, ECO:0000269|Ref.5 |
| Chain | Residue | Details |
| A | THR115 | |
| A | GLY147 | |
| B | THR115 | |
| B | GLY147 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:21969609 |
| Chain | Residue | Details |
| A | ALA2 | |
| B | ALA2 |
