4X48

Crystal structure of GluR2 ligand-binding core

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue GLU A 801

Chain	Residue
A	TYR450
A	GLU705
A	TYR732
A	HOH936
A	HOH940
A	HOH1036
A	PRO478
A	LEU479
A	THR480
A	ARG485
A	LEU650
A	GLY653
A	SER654
A	THR655

---

site_id	AC2
Number of Residues	3
Details	binding site for residue ZN A 802

Chain	Residue
A	GLU431
A	HIS435
B	GLU678

---

site_id	AC3
Number of Residues	13
Details	binding site for residue GLU B 801

Chain	Residue
B	TYR450
B	PRO478
B	LEU479
B	THR480
B	ARG485
B	GLY653
B	SER654
B	THR655
B	GLU705
B	TYR732
B	HOH973
B	HOH975
B	HOH979

---

site_id	AC4
Number of Residues	3
Details	binding site for residue ZN B 802

Chain	Residue
B	HIS412
B	GLU419
C	HIS412

---

site_id	AC5
Number of Residues	5
Details	binding site for residue ZN B 803

Chain	Residue
A	GLU678
B	GLU431
B	HIS435
B	LEU753
B	GLN756

---

site_id	AC6
Number of Residues	16
Details	binding site for residue XPF B 804

Chain	Residue
B	LYS493
B	PRO494
B	PRO494
B	PHE495
B	MET496
B	SER497
B	SER497
B	SER729
B	SER729
B	LYS730
B	LYS730
B	GLY731
B	LEU751
B	ASN754
B	ASN754
B	LEU759

---

site_id	AC7
Number of Residues	13
Details	binding site for residue GLU C 801

Chain	Residue
C	TYR450
C	PRO478
C	LEU479
C	THR480
C	ARG485
C	LEU650
C	GLY653
C	SER654
C	THR655
C	GLU705
C	HOH939
C	HOH941
C	HOH1030

---

site_id	AC8
Number of Residues	2
Details	binding site for residue ZN C 802

Chain	Residue
A	HIS412
C	ASP454

---

site_id	AC9
Number of Residues	3
Details	binding site for residue ZN C 803

Chain	Residue
C	GLU431
C	LYS434
C	HIS435

---

site_id	AD1
Number of Residues	21
Details	binding site for residue XPF C 804

Chain	Residue
A	LYS493
A	PRO494
A	PHE495
A	MET496
A	SER497
A	SER729
A	LYS730
A	GLY731
A	LEU751
A	ASN754
A	LEU759
C	LYS493
C	PRO494
C	PHE495
C	SER497
C	SER729
C	LYS730
C	GLY731
C	LEU751
C	ASN754
C	ASP760

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269|PubMed:16483599

Chain	Residue	Details
B	TYR450
B	ARG485
B	GLU705
C	TYR450
C	ARG485
C	GLU705
A	ARG485
A	GLU705
A	TYR450

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
A	PRO478
B	PRO478
C	PRO478

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269|PubMed:25103405

Chain	Residue	Details
C	THR480
C	SER654
C	THR655
A	THR480
A	SER654
A	THR655
B	THR480
B	SER654
B	THR655

---

site_id	SWS_FT_FI4
Number of Residues	9
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG453
A	ARG660
A	LYS752
B	ARG453
B	ARG660
B	LYS752
C	ARG453
C	ARG660
C	LYS752

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE633
B	ILE633
C	ILE633

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER662
B	SER662
C	SER662

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER696
B	SER696
C	SER696

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN392
B	ASN392
C	ASN392

---