4WYS

Crystal structure of thiolase from Escherichia coli

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003985	molecular_function	acetyl-CoA C-acetyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0006631	biological_process	fatty acid metabolic process
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0032991	cellular_component	protein-containing complex
A	0042802	molecular_function	identical protein binding
A	0043442	biological_process	acetoacetic acid catabolic process
A	0044281	biological_process	small molecule metabolic process
B	0003985	molecular_function	acetyl-CoA C-acetyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0006631	biological_process	fatty acid metabolic process
B	0016746	molecular_function	acyltransferase activity
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0032991	cellular_component	protein-containing complex
B	0042802	molecular_function	identical protein binding
B	0043442	biological_process	acetoacetic acid catabolic process
B	0044281	biological_process	small molecule metabolic process
C	0003985	molecular_function	acetyl-CoA C-acetyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0006631	biological_process	fatty acid metabolic process
C	0016746	molecular_function	acyltransferase activity
C	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
C	0032991	cellular_component	protein-containing complex
C	0042802	molecular_function	identical protein binding
C	0043442	biological_process	acetoacetic acid catabolic process
C	0044281	biological_process	small molecule metabolic process
D	0003985	molecular_function	acetyl-CoA C-acetyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0006631	biological_process	fatty acid metabolic process
D	0016746	molecular_function	acyltransferase activity
D	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
D	0032991	cellular_component	protein-containing complex
D	0042802	molecular_function	identical protein binding
D	0043442	biological_process	acetoacetic acid catabolic process
D	0044281	biological_process	small molecule metabolic process

Functional Information from PROSITE/UniProt

site_id	PS00098
Number of Residues	19
Details	THIOLASE_1 Thiolases acyl-enzyme intermediate signature. VNKvCGSGLkSValaaqaI

Chain	Residue	Details
A	VAL84-ILE102

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site_id	PS00099
Number of Residues	14
Details	THIOLASE_3 Thiolases active site. GLATLCIGgGqGiA

Chain	Residue	Details
A	GLY374-ALA387

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site_id	PS00737
Number of Residues	17
Details	THIOLASE_2 Thiolases signature 2. NvnGGaIAlGHPiGaSG

Chain	Residue	Details
A	ASN339-GLY355

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Acyl-thioester intermediate => ECO:0000250

Chain	Residue	Details
A	CYS88
B	CYS88
C	CYS88
D	CYS88

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site_id	SWS_FT_FI2
Number of Residues	8
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10020

Chain	Residue	Details
A	HIS349
A	CYS379
B	HIS349
B	CYS379
C	HIS349
C	CYS379
D	HIS349
D	CYS379

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