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4WNW

Human Cytochrome P450 2D6 Thioridazine Complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0004497molecular_functionmonooxygenase activity
A0005506molecular_functioniron ion binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0006631biological_processfatty acid metabolic process
A0006805biological_processxenobiotic metabolic process
A0008202biological_processsteroid metabolic process
A0008203biological_processcholesterol metabolic process
A0008210biological_processestrogen metabolic process
A0009804biological_processcoumarin metabolic process
A0009820biological_processalkaloid metabolic process
A0009822biological_processalkaloid catabolic process
A0016020cellular_componentmembrane
A0016098biological_processmonoterpenoid metabolic process
A0016491molecular_functionoxidoreductase activity
A0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A0016712molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
A0019369biological_processarachidonic acid metabolic process
A0020037molecular_functionheme binding
A0033076biological_processisoquinoline alkaloid metabolic process
A0042178biological_processxenobiotic catabolic process
A0042572biological_processretinol metabolic process
A0042759biological_processlong-chain fatty acid biosynthetic process
A0043231cellular_componentintracellular membrane-bounded organelle
A0046872molecular_functionmetal ion binding
A0051100biological_processnegative regulation of binding
A0062187molecular_functionanandamide 8,9 epoxidase activity
A0062188molecular_functionanandamide 11,12 epoxidase activity
A0062189molecular_functionanandamide 14,15 epoxidase activity
A0070989biological_processoxidative demethylation
A0090350biological_processnegative regulation of cellular organofluorine metabolic process
B0004497molecular_functionmonooxygenase activity
B0005506molecular_functioniron ion binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0006631biological_processfatty acid metabolic process
B0006805biological_processxenobiotic metabolic process
B0008202biological_processsteroid metabolic process
B0008203biological_processcholesterol metabolic process
B0008210biological_processestrogen metabolic process
B0009804biological_processcoumarin metabolic process
B0009820biological_processalkaloid metabolic process
B0009822biological_processalkaloid catabolic process
B0016020cellular_componentmembrane
B0016098biological_processmonoterpenoid metabolic process
B0016491molecular_functionoxidoreductase activity
B0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B0016712molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
B0019369biological_processarachidonic acid metabolic process
B0020037molecular_functionheme binding
B0033076biological_processisoquinoline alkaloid metabolic process
B0042178biological_processxenobiotic catabolic process
B0042572biological_processretinol metabolic process
B0042759biological_processlong-chain fatty acid biosynthetic process
B0043231cellular_componentintracellular membrane-bounded organelle
B0046872molecular_functionmetal ion binding
B0051100biological_processnegative regulation of binding
B0062187molecular_functionanandamide 8,9 epoxidase activity
B0062188molecular_functionanandamide 11,12 epoxidase activity
B0062189molecular_functionanandamide 14,15 epoxidase activity
B0070989biological_processoxidative demethylation
B0090350biological_processnegative regulation of cellular organofluorine metabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues20
Detailsbinding site for residue HEM A 601
ChainResidue
AARG101
ATHR313
AVAL374
AHIS376
ALEU399
APRO435
APHE436
ASER437
AARG441
ACYS443
AGLY445
AVAL119
ALEU448
APHE120
ATRP128
AARG132
AILE186
AALA305
AGLY306
ATHR309

site_idAC2
Number of Residues14
Detailsbinding site for residue RTZ A 602
ChainResidue
APHE112
APHE120
AALA209
AGLY212
ALEU213
AGLU216
AGLN244
APHE247
AASP301
ASER304
AALA305
AVAL308
AVAL374
APHE483

site_idAC3
Number of Residues1
Detailsbinding site for residue NA A 603
ChainResidue
AGLU216

site_idAC4
Number of Residues19
Detailsbinding site for residue HEM B 601
ChainResidue
BARG101
BVAL119
BPHE120
BTRP128
BARG132
BLEU302
BALA305
BGLY306
BTHR309
BTHR313
BVAL374
BHIS376
BLEU399
BPRO435
BPHE436
BSER437
BARG441
BCYS443
BGLY445

site_idAC5
Number of Residues14
Detailsbinding site for residue RTZ B 602
ChainResidue
BPHE112
BPHE120
BLEU121
BALA209
BGLY212
BLEU213
BGLU216
BGLN244
BALA300
BASP301
BSER304
BALA305
BVAL308
BPHE483

site_idAC6
Number of Residues2
Detailsbinding site for residue NA B 603
ChainResidue
BGLU216
BARG221

site_idAC7
Number of Residues4
Detailsbinding site for residue NI B 604
ChainResidue
BHIS258
BASP270
BGLU273
BGLU287

Functional Information from PROSITE/UniProt
site_idPS00086
Number of Residues10
DetailsCYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FSaGRRACLG
ChainResidueDetails
APHE436-GLY445

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
AASP301
BASP301

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: axial binding residue
ChainResidueDetails
ACYS443
BCYS443

219869

PDB entries from 2024-05-15

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