Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4WNN

SPT16-H2A-H2B FACT HISTONE Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000786	cellular_component	nucleosome
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0006281	biological_process	DNA repair
A	0006325	biological_process	chromatin organization
A	0030527	molecular_function	structural constituent of chromatin
A	0031298	cellular_component	replication fork protection complex
A	0031492	molecular_function	nucleosomal DNA binding
A	0031507	biological_process	heterochromatin formation
A	0032991	cellular_component	protein-containing complex
A	0046982	molecular_function	protein heterodimerization activity
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0030527	molecular_function	structural constituent of chromatin
B	0046982	molecular_function	protein heterodimerization activity
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0006281	biological_process	DNA repair
C	0006325	biological_process	chromatin organization
C	0030527	molecular_function	structural constituent of chromatin
C	0031298	cellular_component	replication fork protection complex
C	0031492	molecular_function	nucleosomal DNA binding
C	0031507	biological_process	heterochromatin formation
C	0032991	cellular_component	protein-containing complex
C	0046982	molecular_function	protein heterodimerization activity
D	0000786	cellular_component	nucleosome
D	0003677	molecular_function	DNA binding
D	0030527	molecular_function	structural constituent of chromatin
D	0046982	molecular_function	protein heterodimerization activity
E	0000122	biological_process	negative regulation of transcription by RNA polymerase II
E	0000786	cellular_component	nucleosome
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005694	cellular_component	chromosome
E	0006281	biological_process	DNA repair
E	0006325	biological_process	chromatin organization
E	0030527	molecular_function	structural constituent of chromatin
E	0031298	cellular_component	replication fork protection complex
E	0031492	molecular_function	nucleosomal DNA binding
E	0031507	biological_process	heterochromatin formation
E	0032991	cellular_component	protein-containing complex
E	0046982	molecular_function	protein heterodimerization activity
F	0000786	cellular_component	nucleosome
F	0003677	molecular_function	DNA binding
F	0030527	molecular_function	structural constituent of chromatin
F	0046982	molecular_function	protein heterodimerization activity
G	0000122	biological_process	negative regulation of transcription by RNA polymerase II
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005694	cellular_component	chromosome
G	0006281	biological_process	DNA repair
G	0006325	biological_process	chromatin organization
G	0030527	molecular_function	structural constituent of chromatin
G	0031298	cellular_component	replication fork protection complex
G	0031492	molecular_function	nucleosomal DNA binding
G	0031507	biological_process	heterochromatin formation
G	0032991	cellular_component	protein-containing complex
G	0046982	molecular_function	protein heterodimerization activity
H	0000786	cellular_component	nucleosome
H	0003677	molecular_function	DNA binding
H	0030527	molecular_function	structural constituent of chromatin
H	0046982	molecular_function	protein heterodimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue PO4 A 201

Chain	Residue
A	THR77
A	ARG78
B	GLY56
C	ASN95

site_id	AC2
Number of Residues	4
Details	binding site for residue PO4 E 201

Chain	Residue
E	THR77
E	ARG78
F	GLY56
G	ASN95

Functional Information from PROSITE/UniProt

site_id	PS00014
Number of Residues	4
Details	ER_TARGET Endoplasmic reticulum targeting sequence. SQEL

Chain	Residue	Details
A	SER128-LEU131

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLtFPV

Chain	Residue	Details
A	ALA22-VAL28

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlILpGELaKHAVSEG

Chain	Residue	Details
B	ARG95-GLY117

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	MOD_RES: N6-succinyllysine => ECO:0000269\|PubMed:22389435

Chain	Residue	Details
B	LYS34
B	LYS46
D	LYS34
D	LYS46
F	LYS34
F	LYS46
H	LYS34
H	LYS46

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N6,N6-dimethyllysine => ECO:0000269\|PubMed:19113941

Chain	Residue	Details
B	LYS37
D	LYS37
F	LYS37
H	LYS37

site_id	SWS_FT_FI3
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:10642555, ECO:0000269\|PubMed:12535538, ECO:0000269\|PubMed:12535539, ECO:0000269\|PubMed:14660635, ECO:0000269\|PubMed:15280549, ECO:0000269\|PubMed:16432255

Chain	Residue	Details
B	LYS123
C	LYS4
D	LYS123
G	LYS4
F	LYS123
H	LYS123

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:10082517, ECO:0000269\|PubMed:11545749

Chain	Residue	Details
A	LYS7
C	LYS7
E	LYS7
G	LYS7

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: N6-succinyllysine => ECO:0000269\|PubMed:22389435

Chain	Residue	Details
A	LYS13
A	LYS21
C	LYS13
C	LYS21
E	LYS13
E	LYS21
G	LYS13
G	LYS21

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: N5-methylglutamine => ECO:0000269\|PubMed:24352239

Chain	Residue	Details
A	GLN105
C	GLN105
E	GLN105
G	GLN105

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: N6-malonyllysine; alternate => ECO:0000269\|PubMed:22389435

Chain	Residue	Details
A	LYS119
C	LYS119
E	LYS119
G	LYS119

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:11140636

Chain	Residue	Details
A	SER128
C	SER128
E	SER128
G	SER128

site_id	SWS_FT_FI9
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)

Chain	Residue	Details
A	LYS126
C	LYS126
E	LYS126
G	LYS126

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)