4WBH

STRUCTURE OF THE WNT DEACYLASE NOTUM - CRYSTAL FORM I APO - 2.2A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004629	molecular_function	phospholipase C activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0016055	biological_process	Wnt signaling pathway
A	0016298	molecular_function	lipase activity
A	0016787	molecular_function	hydrolase activity
A	0030178	biological_process	negative regulation of Wnt signaling pathway
A	0030500	biological_process	regulation of bone mineralization
A	0052689	molecular_function	carboxylic ester hydrolase activity
A	0060348	biological_process	bone development
A	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
A	1990697	biological_process	protein depalmitoleylation
A	1990699	molecular_function	palmitoleyl hydrolase activity
B	0004629	molecular_function	phospholipase C activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005788	cellular_component	endoplasmic reticulum lumen
B	0016055	biological_process	Wnt signaling pathway
B	0016298	molecular_function	lipase activity
B	0016787	molecular_function	hydrolase activity
B	0030178	biological_process	negative regulation of Wnt signaling pathway
B	0030500	biological_process	regulation of bone mineralization
B	0052689	molecular_function	carboxylic ester hydrolase activity
B	0060348	biological_process	bone development
B	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
B	1990697	biological_process	protein depalmitoleylation
B	1990699	molecular_function	palmitoleyl hydrolase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Charge relay system => ECO:0000269|PubMed:25731175

Chain	Residue	Details
A	SER232
A	ASP340
A	HIS389
B	SER232
B	ASP340
B	HIS389

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039

Chain	Residue	Details
A	SER81
B	SER81

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0007744|PDB:4UYU, ECO:0007744|PDB:4UYW, ECO:0007744|PDB:4UYZ, ECO:0007744|PDB:4UZ1, ECO:0007744|PDB:4UZ5, ECO:0007744|PDB:4UZ6, ECO:0007744|PDB:4UZ9, ECO:0007744|PDB:4UZA, ECO:0007744|PDB:4UZL, ECO:0007744|PDB:4UZQ

Chain	Residue	Details
A	ASN96
B	ASN96

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