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4V24

Sphingosine kinase 1 in complex with PF-543

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0001568biological_processblood vessel development
A0001727molecular_functionlipid kinase activity
A0003376biological_processsphingosine-1-phosphate receptor signaling pathway
A0003677molecular_functionDNA binding
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005905cellular_componentclathrin-coated pit
A0006473biological_processprotein acetylation
A0006629biological_processlipid metabolic process
A0006670biological_processsphingosine metabolic process
A0006954biological_processinflammatory response
A0007420biological_processbrain development
A0008283biological_processcell population proliferation
A0008284biological_processpositive regulation of cell population proliferation
A0008289molecular_functionlipid binding
A0008481molecular_functionsphinganine kinase activity
A0010008cellular_componentendosome membrane
A0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
A0010803biological_processregulation of tumor necrosis factor-mediated signaling pathway
A0016020cellular_componentmembrane
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016407molecular_functionacetyltransferase activity
A0017050molecular_functionD-erythro-sphingosine kinase activity
A0019722biological_processcalcium-mediated signaling
A0030100biological_processregulation of endocytosis
A0030139cellular_componentendocytic vesicle
A0030148biological_processsphingolipid biosynthetic process
A0030307biological_processpositive regulation of cell growth
A0030335biological_processpositive regulation of cell migration
A0031398biological_processpositive regulation of protein ubiquitination
A0031901cellular_componentearly endosome membrane
A0032651biological_processregulation of interleukin-1 beta production
A0032740biological_processpositive regulation of interleukin-17 production
A0034612biological_processresponse to tumor necrosis factor
A0035556biological_processintracellular signal transduction
A0035924biological_processcellular response to vascular endothelial growth factor stimulus
A0038036molecular_functionsphingosine-1-phosphate receptor activity
A0043066biological_processnegative regulation of apoptotic process
A0043231cellular_componentintracellular membrane-bounded organelle
A0045202cellular_componentsynapse
A0045766biological_processpositive regulation of angiogenesis
A0045840biological_processpositive regulation of mitotic nuclear division
A0045931biological_processpositive regulation of mitotic cell cycle
A0045987biological_processpositive regulation of smooth muscle contraction
A0046512biological_processsphingosine biosynthetic process
A0046521biological_processsphingoid catabolic process
A0048146biological_processpositive regulation of fibroblast proliferation
A0050764biological_processregulation of phagocytosis
A0051092biological_processpositive regulation of NF-kappaB transcription factor activity
A0051721molecular_functionprotein phosphatase 2A binding
A0070301biological_processcellular response to hydrogen peroxide
A0071363biological_processcellular response to growth factor stimulus
A0071897biological_processDNA biosynthetic process
A0090520biological_processsphingolipid mediated signaling pathway
A0098793cellular_componentpresynapse
A0150077biological_processregulation of neuroinflammatory response
A1900060biological_processnegative regulation of ceramide biosynthetic process
A1900745biological_processpositive regulation of p38MAPK cascade
A1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
A1903978biological_processregulation of microglial cell activation
A1905364biological_processregulation of endosomal vesicle fusion
B0000287molecular_functionmagnesium ion binding
B0001568biological_processblood vessel development
B0001727molecular_functionlipid kinase activity
B0003376biological_processsphingosine-1-phosphate receptor signaling pathway
B0003677molecular_functionDNA binding
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005768cellular_componentendosome
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005905cellular_componentclathrin-coated pit
B0006473biological_processprotein acetylation
B0006629biological_processlipid metabolic process
B0006670biological_processsphingosine metabolic process
B0006954biological_processinflammatory response
B0007420biological_processbrain development
B0008283biological_processcell population proliferation
B0008284biological_processpositive regulation of cell population proliferation
B0008289molecular_functionlipid binding
B0008481molecular_functionsphinganine kinase activity
B0010008cellular_componentendosome membrane
B0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
B0010803biological_processregulation of tumor necrosis factor-mediated signaling pathway
B0016020cellular_componentmembrane
B0016301molecular_functionkinase activity
B0016310biological_processphosphorylation
B0016407molecular_functionacetyltransferase activity
B0017050molecular_functionD-erythro-sphingosine kinase activity
B0019722biological_processcalcium-mediated signaling
B0030100biological_processregulation of endocytosis
B0030139cellular_componentendocytic vesicle
B0030148biological_processsphingolipid biosynthetic process
B0030307biological_processpositive regulation of cell growth
B0030335biological_processpositive regulation of cell migration
B0031398biological_processpositive regulation of protein ubiquitination
B0031901cellular_componentearly endosome membrane
B0032651biological_processregulation of interleukin-1 beta production
B0032740biological_processpositive regulation of interleukin-17 production
B0034612biological_processresponse to tumor necrosis factor
B0035556biological_processintracellular signal transduction
B0035924biological_processcellular response to vascular endothelial growth factor stimulus
B0038036molecular_functionsphingosine-1-phosphate receptor activity
B0043066biological_processnegative regulation of apoptotic process
B0043231cellular_componentintracellular membrane-bounded organelle
B0045202cellular_componentsynapse
B0045766biological_processpositive regulation of angiogenesis
B0045840biological_processpositive regulation of mitotic nuclear division
B0045931biological_processpositive regulation of mitotic cell cycle
B0045987biological_processpositive regulation of smooth muscle contraction
B0046512biological_processsphingosine biosynthetic process
B0046521biological_processsphingoid catabolic process
B0048146biological_processpositive regulation of fibroblast proliferation
B0050764biological_processregulation of phagocytosis
B0051092biological_processpositive regulation of NF-kappaB transcription factor activity
B0051721molecular_functionprotein phosphatase 2A binding
B0070301biological_processcellular response to hydrogen peroxide
B0071363biological_processcellular response to growth factor stimulus
B0071897biological_processDNA biosynthetic process
B0090520biological_processsphingolipid mediated signaling pathway
B0098793cellular_componentpresynapse
B0150077biological_processregulation of neuroinflammatory response
B1900060biological_processnegative regulation of ceramide biosynthetic process
B1900745biological_processpositive regulation of p38MAPK cascade
B1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
B1903978biological_processregulation of microglial cell activation
B1905364biological_processregulation of endosomal vesicle fusion
Functional Information from PDB Data
site_idAC1
Number of Residues12
DetailsBINDING SITE FOR RESIDUE GYR A 1450
ChainResidue
APHE259
AHIS397
ALEU405
AHOH2123
AILE260
AVAL263
AASP264
ATHR282
AMET358
AALA360
APHE374
ALEU388

site_idAC2
Number of Residues14
DetailsBINDING SITE FOR RESIDUE GYR B 1450
ChainResidue
BPHE259
BILE260
BVAL263
BASP264
BTHR282
BLEU347
BMET358
BALA360
BPHE374
BLEU388
BMET392
BHIS397
BLEU405
BHOH2140

site_idAC3
Number of Residues1
DetailsBINDING SITE FOR RESIDUE ACT A 1451
ChainResidue
AHOH2229

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:23602659
ChainResidueDetails
AASP167
BASP167

site_idSWS_FT_FI2
Number of Residues18
DetailsBINDING: BINDING => ECO:0000269|PubMed:23602659
ChainResidueDetails
AASN108
BASN108
BTHR140
BSER165
BGLU172
BGLY197
BASP264
BARG271
BARG277
BASP427
ATHR140
ASER165
AGLU172
AGLY197
AASP264
AARG271
AARG277
AASP427

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648
ChainResidueDetails
ATHR279
BTHR279

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:20577214
ChainResidueDetails
ASER311
BSER311

220113

PDB entries from 2024-05-22

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