4V0R

DENGUE VIRUS FULL LENGTH NS5 COMPLEXED WITH GTP AND SAH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003968	molecular_function	RNA-dependent RNA polymerase activity
A	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
A	0004483	molecular_function	mRNA (nucleoside-2'-O-)-methyltransferase activity
A	0005524	molecular_function	ATP binding
A	0008168	molecular_function	methyltransferase activity
A	0032259	biological_process	methylation
A	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1001

Chain	Residue
A	GLU437
A	HIS441
A	CYS446
A	CYS449

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1002

Chain	Residue
A	HIS712
A	HIS714
A	CYS728
A	CYS847

---

site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE SAH A 1051

Chain	Residue
A	GLY58
A	GLY81
A	CYS82
A	GLY86
A	TRP87
A	THR104
A	LYS105
A	HIS110
A	GLU111
A	LYS130
A	ASP131
A	VAL132
A	PHE133
A	ASP146
A	HOH2048
A	HOH2076
A	SER56

---

site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GTP A 1884

Chain	Residue
A	LYS14
A	LEU17
A	ASN18
A	LEU20
A	ARG22
A	PHE25
A	LYS29
A	SER150
A	SER151
A	PRO152
A	ARG211
A	SER213
A	MG1886
A	HOH2004
A	HOH2007

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 1885

Chain	Residue
A	ASP533
A	ASP664
A	HOH2308
A	HOH2309
A	HOH2314
A	HOH2371

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 1886

Chain	Residue
A	GTP1884
A	HOH2007

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT A 1887

Chain	Residue
A	ARG540
A	GLN693

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT A 1888

Chain	Residue
A	HIS52
A	ARG688

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT A 1889

Chain	Residue
A	ARG38
A	LYS42
A	ARG84

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1890

Chain	Residue
A	TYR119
A	ASP256
A	LEU257
A	LYS300
A	LYS355
A	THR360
A	HOH2205

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4

Chain	Residue	Details
A	LYS61
A	ASP146
A	LYS180
A	GLU216

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924

Chain	Residue	Details
A	THR104
A	LYS105
A	ASP131
A	VAL132
A	ILE147
A	TYR218
A	SER56
A	GLY86
A	TRP87

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q6YMS4

Chain	Residue	Details
A	HIS441
A	CYS446
A	CYS449
A	HIS712
A	CYS728
A	CYS847
A	GLU437

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	SITE: mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924

Chain	Residue	Details
A	ASN18
A	PHE25
A	LYS29
A	SER150
A	ARG211
A	SER213
A	LYS14

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	SITE: mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924

Chain	Residue	Details
A	LEU17
A	LEU20

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	SITE: Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924

Chain	Residue	Details
A	LYS61
A	LYS180
A	GLU216

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	SITE: Essential for 2'-O-methyltransferase and N-7 methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924

Chain	Residue	Details
A	ASP146

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P03314

Chain	Residue	Details
A	SER56

---