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4UQQ

Electron density map of GluK2 desensitized state in complex with 2S,4R-4-methylglutamate

Functional Information from GO Data
ChainGOidnamespacecontents
A0000149molecular_functionSNARE binding
A0001662biological_processbehavioral fear response
A0004970molecular_functionglutamate-gated receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005234molecular_functionextracellularly glutamate-gated ion channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006874biological_processintracellular calcium ion homeostasis
A0007268biological_processchemical synaptic transmission
A0008066molecular_functionglutamate receptor activity
A0008328cellular_componentionotropic glutamate receptor complex
A0014069cellular_componentpostsynaptic density
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0015277molecular_functionkainate selective glutamate receptor activity
A0016020cellular_componentmembrane
A0019228biological_processneuronal action potential
A0019722biological_processcalcium-mediated signaling
A0022849molecular_functionglutamate-gated calcium ion channel activity
A0030165molecular_functionPDZ domain binding
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0031624molecular_functionubiquitin conjugating enzyme binding
A0031625molecular_functionubiquitin protein ligase binding
A0032839cellular_componentdendrite cytoplasm
A0032983cellular_componentkainate selective glutamate receptor complex
A0034220biological_processmonoatomic ion transmembrane transport
A0035235biological_processionotropic glutamate receptor signaling pathway
A0035249biological_processsynaptic transmission, glutamatergic
A0038023molecular_functionsignaling receptor activity
A0042391biological_processregulation of membrane potential
A0042734cellular_componentpresynaptic membrane
A0042802molecular_functionidentical protein binding
A0043025cellular_componentneuronal cell body
A0043113biological_processreceptor clustering
A0043195cellular_componentterminal bouton
A0043204cellular_componentperikaryon
A0043524biological_processnegative regulation of neuron apoptotic process
A0043525biological_processpositive regulation of neuron apoptotic process
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0046328biological_processregulation of JNK cascade
A0048169biological_processregulation of long-term neuronal synaptic plasticity
A0048172biological_processregulation of short-term neuronal synaptic plasticity
A0050804biological_processmodulation of chemical synaptic transmission
A0050806biological_processpositive regulation of synaptic transmission
A0051402biological_processneuron apoptotic process
A0051967biological_processnegative regulation of synaptic transmission, glutamatergic
A0060079biological_processexcitatory postsynaptic potential
A0060080biological_processinhibitory postsynaptic potential
A0097110molecular_functionscaffold protein binding
A0097471cellular_componentmossy fiber rosette
A0098686cellular_componenthippocampal mossy fiber to CA3 synapse
A0098815biological_processmodulation of excitatory postsynaptic potential
A0098839cellular_componentpostsynaptic density membrane
A0098978cellular_componentglutamatergic synapse
A0099171biological_processpresynaptic modulation of chemical synaptic transmission
A0099505biological_processregulation of presynaptic membrane potential
A0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
A0120169biological_processdetection of cold stimulus involved in thermoception
A1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
B0000149molecular_functionSNARE binding
B0001662biological_processbehavioral fear response
B0004970molecular_functionglutamate-gated receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005234molecular_functionextracellularly glutamate-gated ion channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006874biological_processintracellular calcium ion homeostasis
B0007268biological_processchemical synaptic transmission
B0008066molecular_functionglutamate receptor activity
B0008328cellular_componentionotropic glutamate receptor complex
B0014069cellular_componentpostsynaptic density
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0015277molecular_functionkainate selective glutamate receptor activity
B0016020cellular_componentmembrane
B0019228biological_processneuronal action potential
B0019722biological_processcalcium-mediated signaling
B0022849molecular_functionglutamate-gated calcium ion channel activity
B0030165molecular_functionPDZ domain binding
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0031624molecular_functionubiquitin conjugating enzyme binding
B0031625molecular_functionubiquitin protein ligase binding
B0032839cellular_componentdendrite cytoplasm
B0032983cellular_componentkainate selective glutamate receptor complex
B0034220biological_processmonoatomic ion transmembrane transport
B0035235biological_processionotropic glutamate receptor signaling pathway
B0035249biological_processsynaptic transmission, glutamatergic
B0038023molecular_functionsignaling receptor activity
B0042391biological_processregulation of membrane potential
B0042734cellular_componentpresynaptic membrane
B0042802molecular_functionidentical protein binding
B0043025cellular_componentneuronal cell body
B0043113biological_processreceptor clustering
B0043195cellular_componentterminal bouton
B0043204cellular_componentperikaryon
B0043524biological_processnegative regulation of neuron apoptotic process
B0043525biological_processpositive regulation of neuron apoptotic process
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0046328biological_processregulation of JNK cascade
B0048169biological_processregulation of long-term neuronal synaptic plasticity
B0048172biological_processregulation of short-term neuronal synaptic plasticity
B0050804biological_processmodulation of chemical synaptic transmission
B0050806biological_processpositive regulation of synaptic transmission
B0051402biological_processneuron apoptotic process
B0051967biological_processnegative regulation of synaptic transmission, glutamatergic
B0060079biological_processexcitatory postsynaptic potential
B0060080biological_processinhibitory postsynaptic potential
B0097110molecular_functionscaffold protein binding
B0097471cellular_componentmossy fiber rosette
B0098686cellular_componenthippocampal mossy fiber to CA3 synapse
B0098815biological_processmodulation of excitatory postsynaptic potential
B0098839cellular_componentpostsynaptic density membrane
B0098978cellular_componentglutamatergic synapse
B0099171biological_processpresynaptic modulation of chemical synaptic transmission
B0099505biological_processregulation of presynaptic membrane potential
B0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
B0120169biological_processdetection of cold stimulus involved in thermoception
B1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
C0000149molecular_functionSNARE binding
C0001662biological_processbehavioral fear response
C0004970molecular_functionglutamate-gated receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005234molecular_functionextracellularly glutamate-gated ion channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006874biological_processintracellular calcium ion homeostasis
C0007268biological_processchemical synaptic transmission
C0008066molecular_functionglutamate receptor activity
C0008328cellular_componentionotropic glutamate receptor complex
C0014069cellular_componentpostsynaptic density
C0015276molecular_functionligand-gated monoatomic ion channel activity
C0015277molecular_functionkainate selective glutamate receptor activity
C0016020cellular_componentmembrane
C0019228biological_processneuronal action potential
C0019722biological_processcalcium-mediated signaling
C0022849molecular_functionglutamate-gated calcium ion channel activity
C0030165molecular_functionPDZ domain binding
C0030424cellular_componentaxon
C0030425cellular_componentdendrite
C0031624molecular_functionubiquitin conjugating enzyme binding
C0031625molecular_functionubiquitin protein ligase binding
C0032839cellular_componentdendrite cytoplasm
C0032983cellular_componentkainate selective glutamate receptor complex
C0034220biological_processmonoatomic ion transmembrane transport
C0035235biological_processionotropic glutamate receptor signaling pathway
C0035249biological_processsynaptic transmission, glutamatergic
C0038023molecular_functionsignaling receptor activity
C0042391biological_processregulation of membrane potential
C0042734cellular_componentpresynaptic membrane
C0042802molecular_functionidentical protein binding
C0043025cellular_componentneuronal cell body
C0043113biological_processreceptor clustering
C0043195cellular_componentterminal bouton
C0043204cellular_componentperikaryon
C0043524biological_processnegative regulation of neuron apoptotic process
C0043525biological_processpositive regulation of neuron apoptotic process
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0046328biological_processregulation of JNK cascade
C0048169biological_processregulation of long-term neuronal synaptic plasticity
C0048172biological_processregulation of short-term neuronal synaptic plasticity
C0050804biological_processmodulation of chemical synaptic transmission
C0050806biological_processpositive regulation of synaptic transmission
C0051402biological_processneuron apoptotic process
C0051967biological_processnegative regulation of synaptic transmission, glutamatergic
C0060079biological_processexcitatory postsynaptic potential
C0060080biological_processinhibitory postsynaptic potential
C0097110molecular_functionscaffold protein binding
C0097471cellular_componentmossy fiber rosette
C0098686cellular_componenthippocampal mossy fiber to CA3 synapse
C0098815biological_processmodulation of excitatory postsynaptic potential
C0098839cellular_componentpostsynaptic density membrane
C0098978cellular_componentglutamatergic synapse
C0099171biological_processpresynaptic modulation of chemical synaptic transmission
C0099505biological_processregulation of presynaptic membrane potential
C0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
C0120169biological_processdetection of cold stimulus involved in thermoception
C1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
D0000149molecular_functionSNARE binding
D0001662biological_processbehavioral fear response
D0004970molecular_functionglutamate-gated receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005234molecular_functionextracellularly glutamate-gated ion channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006874biological_processintracellular calcium ion homeostasis
D0007268biological_processchemical synaptic transmission
D0008066molecular_functionglutamate receptor activity
D0008328cellular_componentionotropic glutamate receptor complex
D0014069cellular_componentpostsynaptic density
D0015276molecular_functionligand-gated monoatomic ion channel activity
D0015277molecular_functionkainate selective glutamate receptor activity
D0016020cellular_componentmembrane
D0019228biological_processneuronal action potential
D0019722biological_processcalcium-mediated signaling
D0022849molecular_functionglutamate-gated calcium ion channel activity
D0030165molecular_functionPDZ domain binding
D0030424cellular_componentaxon
D0030425cellular_componentdendrite
D0031624molecular_functionubiquitin conjugating enzyme binding
D0031625molecular_functionubiquitin protein ligase binding
D0032839cellular_componentdendrite cytoplasm
D0032983cellular_componentkainate selective glutamate receptor complex
D0034220biological_processmonoatomic ion transmembrane transport
D0035235biological_processionotropic glutamate receptor signaling pathway
D0035249biological_processsynaptic transmission, glutamatergic
D0038023molecular_functionsignaling receptor activity
D0042391biological_processregulation of membrane potential
D0042734cellular_componentpresynaptic membrane
D0042802molecular_functionidentical protein binding
D0043025cellular_componentneuronal cell body
D0043113biological_processreceptor clustering
D0043195cellular_componentterminal bouton
D0043204cellular_componentperikaryon
D0043524biological_processnegative regulation of neuron apoptotic process
D0043525biological_processpositive regulation of neuron apoptotic process
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0046328biological_processregulation of JNK cascade
D0048169biological_processregulation of long-term neuronal synaptic plasticity
D0048172biological_processregulation of short-term neuronal synaptic plasticity
D0050804biological_processmodulation of chemical synaptic transmission
D0050806biological_processpositive regulation of synaptic transmission
D0051402biological_processneuron apoptotic process
D0051967biological_processnegative regulation of synaptic transmission, glutamatergic
D0060079biological_processexcitatory postsynaptic potential
D0060080biological_processinhibitory postsynaptic potential
D0097110molecular_functionscaffold protein binding
D0097471cellular_componentmossy fiber rosette
D0098686cellular_componenthippocampal mossy fiber to CA3 synapse
D0098815biological_processmodulation of excitatory postsynaptic potential
D0098839cellular_componentpostsynaptic density membrane
D0098978cellular_componentglutamatergic synapse
D0099171biological_processpresynaptic modulation of chemical synaptic transmission
D0099505biological_processregulation of presynaptic membrane potential
D0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
D0120169biological_processdetection of cold stimulus involved in thermoception
D1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Functional Information from PDB Data
site_idAC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GLU A 999
ChainResidue
ATYR457
APRO485
ALEU486
AALA487
AARG492
AGLY657
AALA658
ATHR659
AGLU707

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GLU B 999
ChainResidue
BTYR457
BPRO485
BLEU486
BALA487
BARG492
BGLY657
BALA658
BTHR659
BGLU707

site_idAC3
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GLU C 999
ChainResidue
CTYR457
CPRO485
CLEU486
CALA487
CARG492
CGLY657
CALA658
CTHR659
CGLU707

site_idAC4
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GLU D 999
ChainResidue
DTYR457
DPRO485
DLEU486
DALA487
DARG492
DGLY657
DALA658
DTHR659
DGLU707

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2752
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
ATHR1-PRO530
ATHR629-ASN788
BTHR1-PRO530
BTHR629-ASN788
CTHR1-PRO530
CTHR629-ASN788
DTHR1-PRO530
DTHR629-ASN788

site_idSWS_FT_FI2
Number of Residues240
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
AASP531-ALA551
AILE608-LEU628
AILE789-GLY809
BASP531-ALA551
BILE608-LEU628
BILE789-GLY809
CASP531-ALA551
CILE608-LEU628
CILE789-GLY809
DASP531-ALA551
DILE608-LEU628
DILE789-GLY809

site_idSWS_FT_FI3
Number of Residues488
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AARG552-GLY607
AGLU810-ALA877
BARG552-GLY607
BGLU810-ALA877
CARG552-GLY607
CGLU810-ALA877
DARG552-GLY607
DGLU810-ALA877

site_idSWS_FT_FI4
Number of Residues16
DetailsBINDING: BINDING => ECO:0000269|PubMed:15721240, ECO:0000269|PubMed:17115050, ECO:0007744|PDB:1S50, ECO:0007744|PDB:1S7Y, ECO:0007744|PDB:2I0B, ECO:0007744|PDB:2I0C
ChainResidueDetails
CPRO485
CARG492
CALA658
CGLU707
DPRO485
DARG492
DALA658
DGLU707
APRO485
AARG492
AALA658
AGLU707
BPRO485
BARG492
BALA658
BGLU707

site_idSWS_FT_FI5
Number of Residues8
DetailsMOD_RES: Phosphoserine; by PKC => ECO:0000250|UniProtKB:Q13002
ChainResidueDetails
ASER815
ASER837
BSER815
BSER837
CSER815
CSER837
DSER815
DSER837

site_idSWS_FT_FI6
Number of Residues12
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21791290
ChainResidueDetails
AASN36
AASN347
AASN381
BASN36
BASN347
BASN381
CASN36
CASN347
CASN381
DASN36
DASN347
DASN381

site_idSWS_FT_FI7
Number of Residues16
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN244
AASN515
BASN244
BASN515
CASN42
CASN244
CASN399
CASN515
DASN42
DASN244
DASN399
DASN515
BASN42
BASN399
AASN42
AASN399

site_idSWS_FT_FI8
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15677325
ChainResidueDetails
AASN392
AASN720
BASN392
BASN720
CASN392
CASN720
DASN392
DASN720

site_idSWS_FT_FI9
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0000269|PubMed:17486098
ChainResidueDetails
ALYS855
BLYS855
CLYS855
DLYS855

219869

PDB entries from 2024-05-15

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