4TVX

Crystal structure of the E. coli CRISPR RNA-guided surveillance complex, Cascade

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0004519	molecular_function	endonuclease activity
A	0004521	molecular_function	RNA endonuclease activity
A	0005515	molecular_function	protein binding
A	0006396	biological_process	RNA processing
A	0032991	cellular_component	protein-containing complex
A	0051607	biological_process	defense response to virus
A	0099048	biological_process	CRISPR-cas system
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0032991	cellular_component	protein-containing complex
B	0051607	biological_process	defense response to virus
B	0071667	molecular_function	DNA/RNA hybrid binding
B	0099048	biological_process	CRISPR-cas system
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0032991	cellular_component	protein-containing complex
C	0051607	biological_process	defense response to virus
C	0071667	molecular_function	DNA/RNA hybrid binding
C	0099048	biological_process	CRISPR-cas system
D	0003723	molecular_function	RNA binding
D	0005515	molecular_function	protein binding
D	0032991	cellular_component	protein-containing complex
D	0051607	biological_process	defense response to virus
D	0071667	molecular_function	DNA/RNA hybrid binding
D	0099048	biological_process	CRISPR-cas system
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0032991	cellular_component	protein-containing complex
E	0051607	biological_process	defense response to virus
E	0071667	molecular_function	DNA/RNA hybrid binding
E	0099048	biological_process	CRISPR-cas system
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0032991	cellular_component	protein-containing complex
F	0051607	biological_process	defense response to virus
F	0071667	molecular_function	DNA/RNA hybrid binding
F	0099048	biological_process	CRISPR-cas system
G	0003723	molecular_function	RNA binding
G	0005515	molecular_function	protein binding
G	0032991	cellular_component	protein-containing complex
G	0051607	biological_process	defense response to virus
G	0071667	molecular_function	DNA/RNA hybrid binding
G	0099048	biological_process	CRISPR-cas system
H	0003723	molecular_function	RNA binding
H	0005515	molecular_function	protein binding
H	0032991	cellular_component	protein-containing complex
H	0043571	biological_process	maintenance of CRISPR repeat elements
H	0051607	biological_process	defense response to virus
H	0071667	molecular_function	DNA/RNA hybrid binding
H	0099048	biological_process	CRISPR-cas system
I	0003677	molecular_function	DNA binding
I	0003723	molecular_function	RNA binding
I	0005515	molecular_function	protein binding
I	0008270	molecular_function	zinc ion binding
I	0032991	cellular_component	protein-containing complex
I	0051607	biological_process	defense response to virus
I	0099048	biological_process	CRISPR-cas system
J	0003676	molecular_function	nucleic acid binding
J	0003677	molecular_function	DNA binding
J	0003723	molecular_function	RNA binding
J	0005515	molecular_function	protein binding
J	0032991	cellular_component	protein-containing complex
J	0051607	biological_process	defense response to virus
J	0099048	biological_process	CRISPR-cas system
K	0003676	molecular_function	nucleic acid binding
K	0003677	molecular_function	DNA binding
K	0003723	molecular_function	RNA binding
K	0005515	molecular_function	protein binding
K	0032991	cellular_component	protein-containing complex
K	0051607	biological_process	defense response to virus
K	0099048	biological_process	CRISPR-cas system
M	0003723	molecular_function	RNA binding
M	0004519	molecular_function	endonuclease activity
M	0004521	molecular_function	RNA endonuclease activity
M	0005515	molecular_function	protein binding
M	0006396	biological_process	RNA processing
M	0032991	cellular_component	protein-containing complex
M	0051607	biological_process	defense response to virus
M	0099048	biological_process	CRISPR-cas system
N	0003723	molecular_function	RNA binding
N	0005515	molecular_function	protein binding
N	0032991	cellular_component	protein-containing complex
N	0051607	biological_process	defense response to virus
N	0071667	molecular_function	DNA/RNA hybrid binding
N	0099048	biological_process	CRISPR-cas system
O	0003723	molecular_function	RNA binding
O	0005515	molecular_function	protein binding
O	0032991	cellular_component	protein-containing complex
O	0051607	biological_process	defense response to virus
O	0071667	molecular_function	DNA/RNA hybrid binding
O	0099048	biological_process	CRISPR-cas system
P	0003723	molecular_function	RNA binding
P	0005515	molecular_function	protein binding
P	0032991	cellular_component	protein-containing complex
P	0051607	biological_process	defense response to virus
P	0071667	molecular_function	DNA/RNA hybrid binding
P	0099048	biological_process	CRISPR-cas system
Q	0003723	molecular_function	RNA binding
Q	0005515	molecular_function	protein binding
Q	0032991	cellular_component	protein-containing complex
Q	0051607	biological_process	defense response to virus
Q	0071667	molecular_function	DNA/RNA hybrid binding
Q	0099048	biological_process	CRISPR-cas system
R	0003723	molecular_function	RNA binding
R	0005515	molecular_function	protein binding
R	0032991	cellular_component	protein-containing complex
R	0051607	biological_process	defense response to virus
R	0071667	molecular_function	DNA/RNA hybrid binding
R	0099048	biological_process	CRISPR-cas system
S	0003723	molecular_function	RNA binding
S	0005515	molecular_function	protein binding
S	0032991	cellular_component	protein-containing complex
S	0051607	biological_process	defense response to virus
S	0071667	molecular_function	DNA/RNA hybrid binding
S	0099048	biological_process	CRISPR-cas system
T	0003723	molecular_function	RNA binding
T	0005515	molecular_function	protein binding
T	0032991	cellular_component	protein-containing complex
T	0043571	biological_process	maintenance of CRISPR repeat elements
T	0051607	biological_process	defense response to virus
T	0071667	molecular_function	DNA/RNA hybrid binding
T	0099048	biological_process	CRISPR-cas system
U	0003677	molecular_function	DNA binding
U	0003723	molecular_function	RNA binding
U	0005515	molecular_function	protein binding
U	0008270	molecular_function	zinc ion binding
U	0032991	cellular_component	protein-containing complex
U	0051607	biological_process	defense response to virus
U	0099048	biological_process	CRISPR-cas system
V	0003676	molecular_function	nucleic acid binding
V	0003677	molecular_function	DNA binding
V	0003723	molecular_function	RNA binding
V	0005515	molecular_function	protein binding
V	0032991	cellular_component	protein-containing complex
V	0051607	biological_process	defense response to virus
V	0099048	biological_process	CRISPR-cas system
W	0003676	molecular_function	nucleic acid binding
W	0003677	molecular_function	DNA binding
W	0003723	molecular_function	RNA binding
W	0005515	molecular_function	protein binding
W	0032991	cellular_component	protein-containing complex
W	0051607	biological_process	defense response to virus
W	0099048	biological_process	CRISPR-cas system

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue ZN U 601

Chain	Residue
U	CYS140
U	CYS143
U	CYS250
U	CYS252
U	CYS253

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site_id	AC2
Number of Residues	4
Details	binding site for residue ZN I 601

Chain	Residue
I	CYS140
I	CYS143
I	CYS250
I	CYS253

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