4TMN

SLOW-AND FAST-BINDING INHIBITORS OF THERMOLYSIN DISPLAY DIFFERENT MODES OF BINDING. CRYSTALLOGRAPHIC ANALYSIS OF EXTENDED PHOSPHONAMIDATE TRANSITION-STATE ANALOGUES

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0004222	molecular_function	metalloendopeptidase activity
E	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 0PK E 317

Chain	Residue
E	TYR106
E	GLU166
E	LEU202
E	ARG203
E	HIS231
E	ZN322
E	HOH481
E	HOH482
E	HOH484
E	ASN112
E	ALA113
E	PHE114
E	TRP115
E	HIS142
E	GLU143
E	HIS146
E	TYR157

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 318

Chain	Residue
E	ASP138
E	GLU177
E	ASP185
E	GLU187
E	GLU190
E	HOH335

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 319

Chain	Residue
E	GLU177
E	ASN183
E	ASP185
E	GLU190
E	HOH342
E	HOH423

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 320

Chain	Residue
E	ASP57
E	ASP59
E	GLN61
E	HOH386
E	HOH430
E	HOH446

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 321

Chain	Residue
E	TYR193
E	THR194
E	ILE197
E	ASP200
E	HOH343
E	HOH428

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 322

Chain	Residue
E	HIS142
E	HIS146
E	GLU166
E	0PK317

---

site_id	S1
Number of Residues	1
Details	SUBSITE S1

Chain	Residue
E	PHE114

---

site_id	S1P
Number of Residues	7
Details	SUBSITE S1(PRIME)

Chain	Residue
E	PHE130
E	LEU133
E	VAL139
E	ILE188
E	GLY189
E	VAL192
E	LEU202

---

site_id	S2
Number of Residues	1
Details	SUBSITE S2

Chain	Residue
E	TRP115

---

site_id	S2P
Number of Residues	2
Details	SUBSITE S2(PRIME)

Chain	Residue
E	PHE130
E	LEU202

---

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVAHELTHAV

Chain	Residue	Details
E	VAL139-VAL148

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
E	VAL289
E	SER291
E	THR293

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 176

Chain

Residue

Details

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