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4TLM

Crystal structure of GluN1/GluN2B NMDA receptor, structure 2

Functional Information from GO Data
ChainGOidnamespacecontents
A0004972molecular_functionNMDA glutamate receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0007215biological_processglutamate receptor signaling pathway
A0007268biological_processchemical synaptic transmission
A0010043biological_processresponse to zinc ion
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0016020cellular_componentmembrane
A0017146cellular_componentNMDA selective glutamate receptor complex
A0022824molecular_functiontransmitter-gated monoatomic ion channel activity
A0034220biological_processmonoatomic ion transmembrane transport
A0035235biological_processionotropic glutamate receptor signaling pathway
A0038023molecular_functionsignaling receptor activity
A0042391biological_processregulation of membrane potential
A0043005cellular_componentneuron projection
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0046872molecular_functionmetal ion binding
B0005216molecular_functionmonoatomic ion channel activity
B0006811biological_processmonoatomic ion transport
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0016020cellular_componentmembrane
B0038023molecular_functionsignaling receptor activity
C0004972molecular_functionNMDA glutamate receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0007215biological_processglutamate receptor signaling pathway
C0007268biological_processchemical synaptic transmission
C0010043biological_processresponse to zinc ion
C0015276molecular_functionligand-gated monoatomic ion channel activity
C0016020cellular_componentmembrane
C0017146cellular_componentNMDA selective glutamate receptor complex
C0022824molecular_functiontransmitter-gated monoatomic ion channel activity
C0034220biological_processmonoatomic ion transmembrane transport
C0035235biological_processionotropic glutamate receptor signaling pathway
C0038023molecular_functionsignaling receptor activity
C0042391biological_processregulation of membrane potential
C0043005cellular_componentneuron projection
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0046872molecular_functionmetal ion binding
D0005216molecular_functionmonoatomic ion channel activity
D0006811biological_processmonoatomic ion transport
D0015276molecular_functionligand-gated monoatomic ion channel activity
D0016020cellular_componentmembrane
D0038023molecular_functionsignaling receptor activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1408
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:25008524
ChainResidueDetails
BGLN25-MET554
BARG640-SER815
DGLN25-MET554
DARG640-SER815
CPHE629-LEU645
CALA811-ALA831

site_idSWS_FT_FI2
Number of Residues66
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:25008524
ChainResidueDetails
BVAL551-VAL569
BILE624-GLN639
DVAL551-VAL569
DILE624-GLN639

site_idSWS_FT_FI3
Number of Residues64
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:25008524
ChainResidueDetails
BPHE570-VAL596
BVAL617-VAL623
DPHE570-VAL596
DVAL617-VAL623

site_idSWS_FT_FI4
Number of Residues38
DetailsINTRAMEM: Discontinuously helical => ECO:0000269|PubMed:25008524
ChainResidueDetails
BPHE597-SER616
DPHE597-SER616

site_idSWS_FT_FI5
Number of Residues38
DetailsTRANSMEM: Helical => ECO:0000250|UniProtKB:Q00960
ChainResidueDetails
BLEU816-MET835
DLEU816-MET835
AASP100
CHIS67
CHIS94
CASP100

site_idSWS_FT_FI6
Number of Residues2
DetailsBINDING: BINDING => ECO:0000305|PubMed:25008524
ChainResidueDetails
BTHR507
DTHR507
AGLN686
AALA730
CPRO514
CARG521
CGLN686
CALA730

site_idSWS_FT_FI7
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q00960
ChainResidueDetails
BARG512
BARG725
DARG512
DARG725

site_idSWS_FT_FI8
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q00959
ChainResidueDetails
BLEU683
DLEU683

site_idSWS_FT_FI9
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:25008524, ECO:0000269|PubMed:28232581, ECO:0007744|PDB:4TLL, ECO:0007744|PDB:5UOW, ECO:0007744|PDB:5UP2
ChainResidueDetails
BASN336
DASN336

site_idSWS_FT_FI10
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:25008524, ECO:0000269|PubMed:28232581, ECO:0007744|PDB:4TLM, ECO:0007744|PDB:5UOW, ECO:0007744|PDB:5UP2
ChainResidueDetails
BASN681
DASN681

site_idSWS_FT_FI11
Number of Residues10
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
ChainResidueDetails
AGLN350
CSER769
AASP440
AASP469
AASN489
ASER769
CGLN350
CASP440
CASP469
CASN489

site_idSWS_FT_FI12
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21677647, ECO:0007744|PDB:3QEK, ECO:0007744|PDB:3QEL, ECO:0007744|PDB:3QEM
ChainResidueDetails
AASP368
CASP368

220113

PDB entries from 2024-05-22

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