Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4S1F

Fructose-6-phosphate aldolase A from E.coli soaked in acetylacetone

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005975	biological_process	carbohydrate metabolic process
A	0006000	biological_process	fructose metabolic process
A	0016829	molecular_function	lyase activity
A	0016832	molecular_function	aldehyde-lyase activity
A	0042182	biological_process	ketone catabolic process
A	0042802	molecular_function	identical protein binding
A	0097023	molecular_function	fructose 6-phosphate aldolase activity
B	0005737	cellular_component	cytoplasm
B	0005975	biological_process	carbohydrate metabolic process
B	0006000	biological_process	fructose metabolic process
B	0016829	molecular_function	lyase activity
B	0016832	molecular_function	aldehyde-lyase activity
B	0042182	biological_process	ketone catabolic process
B	0042802	molecular_function	identical protein binding
B	0097023	molecular_function	fructose 6-phosphate aldolase activity
C	0005737	cellular_component	cytoplasm
C	0005975	biological_process	carbohydrate metabolic process
C	0006000	biological_process	fructose metabolic process
C	0016829	molecular_function	lyase activity
C	0016832	molecular_function	aldehyde-lyase activity
C	0042182	biological_process	ketone catabolic process
C	0042802	molecular_function	identical protein binding
C	0097023	molecular_function	fructose 6-phosphate aldolase activity
D	0005737	cellular_component	cytoplasm
D	0005975	biological_process	carbohydrate metabolic process
D	0006000	biological_process	fructose metabolic process
D	0016829	molecular_function	lyase activity
D	0016832	molecular_function	aldehyde-lyase activity
D	0042182	biological_process	ketone catabolic process
D	0042802	molecular_function	identical protein binding
D	0097023	molecular_function	fructose 6-phosphate aldolase activity
E	0005737	cellular_component	cytoplasm
E	0005975	biological_process	carbohydrate metabolic process
E	0006000	biological_process	fructose metabolic process
E	0016829	molecular_function	lyase activity
E	0016832	molecular_function	aldehyde-lyase activity
E	0042182	biological_process	ketone catabolic process
E	0042802	molecular_function	identical protein binding
E	0097023	molecular_function	fructose 6-phosphate aldolase activity
F	0005737	cellular_component	cytoplasm
F	0005975	biological_process	carbohydrate metabolic process
F	0006000	biological_process	fructose metabolic process
F	0016829	molecular_function	lyase activity
F	0016832	molecular_function	aldehyde-lyase activity
F	0042182	biological_process	ketone catabolic process
F	0042802	molecular_function	identical protein binding
F	0097023	molecular_function	fructose 6-phosphate aldolase activity
G	0005737	cellular_component	cytoplasm
G	0005975	biological_process	carbohydrate metabolic process
G	0006000	biological_process	fructose metabolic process
G	0016829	molecular_function	lyase activity
G	0016832	molecular_function	aldehyde-lyase activity
G	0042182	biological_process	ketone catabolic process
G	0042802	molecular_function	identical protein binding
G	0097023	molecular_function	fructose 6-phosphate aldolase activity
H	0005737	cellular_component	cytoplasm
H	0005975	biological_process	carbohydrate metabolic process
H	0006000	biological_process	fructose metabolic process
H	0016829	molecular_function	lyase activity
H	0016832	molecular_function	aldehyde-lyase activity
H	0042182	biological_process	ketone catabolic process
H	0042802	molecular_function	identical protein binding
H	0097023	molecular_function	fructose 6-phosphate aldolase activity
I	0005737	cellular_component	cytoplasm
I	0005975	biological_process	carbohydrate metabolic process
I	0006000	biological_process	fructose metabolic process
I	0016829	molecular_function	lyase activity
I	0016832	molecular_function	aldehyde-lyase activity
I	0042182	biological_process	ketone catabolic process
I	0042802	molecular_function	identical protein binding
I	0097023	molecular_function	fructose 6-phosphate aldolase activity
J	0005737	cellular_component	cytoplasm
J	0005975	biological_process	carbohydrate metabolic process
J	0006000	biological_process	fructose metabolic process
J	0016829	molecular_function	lyase activity
J	0016832	molecular_function	aldehyde-lyase activity
J	0042182	biological_process	ketone catabolic process
J	0042802	molecular_function	identical protein binding
J	0097023	molecular_function	fructose 6-phosphate aldolase activity
K	0005737	cellular_component	cytoplasm
K	0005975	biological_process	carbohydrate metabolic process
K	0006000	biological_process	fructose metabolic process
K	0016829	molecular_function	lyase activity
K	0016832	molecular_function	aldehyde-lyase activity
K	0042182	biological_process	ketone catabolic process
K	0042802	molecular_function	identical protein binding
K	0097023	molecular_function	fructose 6-phosphate aldolase activity
L	0005737	cellular_component	cytoplasm
L	0005975	biological_process	carbohydrate metabolic process
L	0006000	biological_process	fructose metabolic process
L	0016829	molecular_function	lyase activity
L	0016832	molecular_function	aldehyde-lyase activity
L	0042182	biological_process	ketone catabolic process
L	0042802	molecular_function	identical protein binding
L	0097023	molecular_function	fructose 6-phosphate aldolase activity
M	0005737	cellular_component	cytoplasm
M	0005975	biological_process	carbohydrate metabolic process
M	0006000	biological_process	fructose metabolic process
M	0016829	molecular_function	lyase activity
M	0016832	molecular_function	aldehyde-lyase activity
M	0042182	biological_process	ketone catabolic process
M	0042802	molecular_function	identical protein binding
M	0097023	molecular_function	fructose 6-phosphate aldolase activity
N	0005737	cellular_component	cytoplasm
N	0005975	biological_process	carbohydrate metabolic process
N	0006000	biological_process	fructose metabolic process
N	0016829	molecular_function	lyase activity
N	0016832	molecular_function	aldehyde-lyase activity
N	0042182	biological_process	ketone catabolic process
N	0042802	molecular_function	identical protein binding
N	0097023	molecular_function	fructose 6-phosphate aldolase activity
O	0005737	cellular_component	cytoplasm
O	0005975	biological_process	carbohydrate metabolic process
O	0006000	biological_process	fructose metabolic process
O	0016829	molecular_function	lyase activity
O	0016832	molecular_function	aldehyde-lyase activity
O	0042182	biological_process	ketone catabolic process
O	0042802	molecular_function	identical protein binding
O	0097023	molecular_function	fructose 6-phosphate aldolase activity
P	0005737	cellular_component	cytoplasm
P	0005975	biological_process	carbohydrate metabolic process
P	0006000	biological_process	fructose metabolic process
P	0016829	molecular_function	lyase activity
P	0016832	molecular_function	aldehyde-lyase activity
P	0042182	biological_process	ketone catabolic process
P	0042802	molecular_function	identical protein binding
P	0097023	molecular_function	fructose 6-phosphate aldolase activity
Q	0005737	cellular_component	cytoplasm
Q	0005975	biological_process	carbohydrate metabolic process
Q	0006000	biological_process	fructose metabolic process
Q	0016829	molecular_function	lyase activity
Q	0016832	molecular_function	aldehyde-lyase activity
Q	0042182	biological_process	ketone catabolic process
Q	0042802	molecular_function	identical protein binding
Q	0097023	molecular_function	fructose 6-phosphate aldolase activity
R	0005737	cellular_component	cytoplasm
R	0005975	biological_process	carbohydrate metabolic process
R	0006000	biological_process	fructose metabolic process
R	0016829	molecular_function	lyase activity
R	0016832	molecular_function	aldehyde-lyase activity
R	0042182	biological_process	ketone catabolic process
R	0042802	molecular_function	identical protein binding
R	0097023	molecular_function	fructose 6-phosphate aldolase activity
S	0005737	cellular_component	cytoplasm
S	0005975	biological_process	carbohydrate metabolic process
S	0006000	biological_process	fructose metabolic process
S	0016829	molecular_function	lyase activity
S	0016832	molecular_function	aldehyde-lyase activity
S	0042182	biological_process	ketone catabolic process
S	0042802	molecular_function	identical protein binding
S	0097023	molecular_function	fructose 6-phosphate aldolase activity
T	0005737	cellular_component	cytoplasm
T	0005975	biological_process	carbohydrate metabolic process
T	0006000	biological_process	fructose metabolic process
T	0016829	molecular_function	lyase activity
T	0016832	molecular_function	aldehyde-lyase activity
T	0042182	biological_process	ketone catabolic process
T	0042802	molecular_function	identical protein binding
T	0097023	molecular_function	fructose 6-phosphate aldolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE P2D B 301

Chain	Residue
B	ASP6
B	THR27
B	ASN28
B	LYS85
B	THR109
B	ALA129
B	HOH415

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE P2D G 301

Chain	Residue
G	ASN28
G	GLN59
G	LYS85
G	THR109
G	TYR131
G	THR185
G	ASP6
G	THR26

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE P2D H 301

Chain	Residue
H	ASP6
H	ASN28
H	LYS85
H	THR109
H	TYR131

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE P2D K 301

Chain	Residue
K	ASP6
K	THR26
K	THR27
K	ASN28
K	LYS85
K	THR109
K	TYR131
K	ALA165

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE P2D P 301

Chain	Residue
P	ASP6
P	ASN28
P	LYS85
P	THR109
P	ALA129
P	TYR131
P	ALA165

Functional Information from PROSITE/UniProt

site_id	PS00958
Number of Residues	18
Details	TRANSALDOLASE_2 Transaldolase active site. IvVKVPvTaEGLaAiKmL

Chain	Residue	Details
A	ILE82-LEU99

site_id	PS01054
Number of Residues	9
Details	TRANSALDOLASE_1 Transaldolase signature 1. GVTTNPSII

Chain	Residue	Details
A	GLY24-ILE32

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	ACT_SITE: Schiff-base intermediate with substrate => ECO:0000269\|PubMed:11120740, ECO:0000269\|PubMed:12051943

Chain	Residue	Details
A	LYS85
B	LYS85
C	LYS85
D	LYS85
E	LYS85
F	LYS85
G	LYS85
H	LYS85
I	LYS85
J	LYS85
K	LYS85
L	LYS85
M	LYS85
N	LYS85
O	LYS85
P	LYS85
Q	LYS85
R	LYS85
S	LYS85
T	LYS85

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)