4RZ4
Fructose-6-phosphate aldolase Q59E Y131F from E.coli
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006000 | biological_process | fructose metabolic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016832 | molecular_function | aldehyde-lyase activity |
| A | 0042182 | biological_process | ketone catabolic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0097023 | molecular_function | fructose 6-phosphate aldolase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006000 | biological_process | fructose metabolic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016832 | molecular_function | aldehyde-lyase activity |
| B | 0042182 | biological_process | ketone catabolic process |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0097023 | molecular_function | fructose 6-phosphate aldolase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0006000 | biological_process | fructose metabolic process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0016832 | molecular_function | aldehyde-lyase activity |
| C | 0042182 | biological_process | ketone catabolic process |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0097023 | molecular_function | fructose 6-phosphate aldolase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0006000 | biological_process | fructose metabolic process |
| D | 0016829 | molecular_function | lyase activity |
| D | 0016832 | molecular_function | aldehyde-lyase activity |
| D | 0042182 | biological_process | ketone catabolic process |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0097023 | molecular_function | fructose 6-phosphate aldolase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005975 | biological_process | carbohydrate metabolic process |
| E | 0006000 | biological_process | fructose metabolic process |
| E | 0016829 | molecular_function | lyase activity |
| E | 0016832 | molecular_function | aldehyde-lyase activity |
| E | 0042182 | biological_process | ketone catabolic process |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0097023 | molecular_function | fructose 6-phosphate aldolase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005975 | biological_process | carbohydrate metabolic process |
| F | 0006000 | biological_process | fructose metabolic process |
| F | 0016829 | molecular_function | lyase activity |
| F | 0016832 | molecular_function | aldehyde-lyase activity |
| F | 0042182 | biological_process | ketone catabolic process |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0097023 | molecular_function | fructose 6-phosphate aldolase activity |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005975 | biological_process | carbohydrate metabolic process |
| G | 0006000 | biological_process | fructose metabolic process |
| G | 0016829 | molecular_function | lyase activity |
| G | 0016832 | molecular_function | aldehyde-lyase activity |
| G | 0042182 | biological_process | ketone catabolic process |
| G | 0042802 | molecular_function | identical protein binding |
| G | 0097023 | molecular_function | fructose 6-phosphate aldolase activity |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005975 | biological_process | carbohydrate metabolic process |
| H | 0006000 | biological_process | fructose metabolic process |
| H | 0016829 | molecular_function | lyase activity |
| H | 0016832 | molecular_function | aldehyde-lyase activity |
| H | 0042182 | biological_process | ketone catabolic process |
| H | 0042802 | molecular_function | identical protein binding |
| H | 0097023 | molecular_function | fructose 6-phosphate aldolase activity |
| I | 0005737 | cellular_component | cytoplasm |
| I | 0005975 | biological_process | carbohydrate metabolic process |
| I | 0006000 | biological_process | fructose metabolic process |
| I | 0016829 | molecular_function | lyase activity |
| I | 0016832 | molecular_function | aldehyde-lyase activity |
| I | 0042182 | biological_process | ketone catabolic process |
| I | 0042802 | molecular_function | identical protein binding |
| I | 0097023 | molecular_function | fructose 6-phosphate aldolase activity |
| J | 0005737 | cellular_component | cytoplasm |
| J | 0005975 | biological_process | carbohydrate metabolic process |
| J | 0006000 | biological_process | fructose metabolic process |
| J | 0016829 | molecular_function | lyase activity |
| J | 0016832 | molecular_function | aldehyde-lyase activity |
| J | 0042182 | biological_process | ketone catabolic process |
| J | 0042802 | molecular_function | identical protein binding |
| J | 0097023 | molecular_function | fructose 6-phosphate aldolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGE A 301 |
| Chain | Residue |
| A | ASP6 |
| A | ASN28 |
| A | LYS85 |
| A | PHE131 |
| A | PGE302 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGE A 302 |
| Chain | Residue |
| A | HOH439 |
| A | ARG134 |
| A | SER166 |
| A | PGE301 |
| A | HOH430 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 A 303 |
| Chain | Residue |
| A | ARG134 |
| A | LYS168 |
| A | HOH495 |
| B | LYS206 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 304 |
| Chain | Residue |
| A | HIS150 |
| A | VAL162 |
| A | GLU182 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGE B 301 |
| Chain | Residue |
| B | ASP6 |
| B | ASN28 |
| B | LYS85 |
| B | PHE131 |
| B | PGE302 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PGE B 302 |
| Chain | Residue |
| B | ASN28 |
| B | ARG134 |
| B | SER166 |
| B | PGE301 |
| B | HOH409 |
| B | HOH417 |
| B | HOH468 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 B 303 |
| Chain | Residue |
| B | ARG134 |
| B | LYS168 |
| B | HOH468 |
| B | HOH506 |
| C | LYS206 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 304 |
| Chain | Residue |
| B | HIS150 |
| B | VAL162 |
| B | GLU182 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PGE C 301 |
| Chain | Residue |
| C | ASP6 |
| C | ASN28 |
| C | LYS85 |
| C | PGE302 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PGE C 302 |
| Chain | Residue |
| C | ASN28 |
| C | ARG134 |
| C | SER166 |
| C | PGE301 |
| C | HOH426 |
| C | HOH430 |
| C | HOH452 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 C 303 |
| Chain | Residue |
| C | ARG134 |
| C | LYS168 |
| C | HOH452 |
| C | HOH461 |
| C | HOH506 |
| D | LYS206 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL C 304 |
| Chain | Residue |
| C | HIS150 |
| C | VAL162 |
| C | GLU182 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGE D 301 |
| Chain | Residue |
| D | ASP6 |
| D | ASN28 |
| D | LYS85 |
| D | PHE131 |
| D | PGE302 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGE D 302 |
| Chain | Residue |
| D | ASN28 |
| D | ARG134 |
| D | SER166 |
| D | PGE301 |
| D | HOH407 |
| D | HOH431 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 D 303 |
| Chain | Residue |
| D | ARG134 |
| D | LYS168 |
| E | LYS206 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL D 304 |
| Chain | Residue |
| D | HIS150 |
| D | VAL162 |
| D | GLU182 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PGE E 301 |
| Chain | Residue |
| E | ASP6 |
| E | ASN28 |
| E | LYS85 |
| E | PGE302 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGE E 302 |
| Chain | Residue |
| E | ARG134 |
| E | SER166 |
| E | PGE301 |
| E | HOH423 |
| E | HOH425 |
| E | HOH444 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 E 303 |
| Chain | Residue |
| A | LYS206 |
| E | ARG134 |
| E | LYS168 |
| E | HOH444 |
| site_id | CC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL E 304 |
| Chain | Residue |
| E | HIS150 |
| E | VAL162 |
| E | GLU182 |
| site_id | CC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGE F 301 |
| Chain | Residue |
| F | ASP6 |
| F | ASN28 |
| F | LYS85 |
| F | PHE131 |
| F | PGE302 |
| site_id | CC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGE F 302 |
| Chain | Residue |
| F | HOH412 |
| F | HOH426 |
| F | HOH511 |
| F | ARG134 |
| F | SER166 |
| F | PGE301 |
| site_id | CC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 F 303 |
| Chain | Residue |
| F | ARG134 |
| F | LYS168 |
| F | HOH484 |
| F | HOH511 |
| J | LYS206 |
| site_id | CC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL F 304 |
| Chain | Residue |
| F | HIS150 |
| F | VAL162 |
| F | GLU182 |
| site_id | CC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PGE G 301 |
| Chain | Residue |
| G | ASP6 |
| G | ASN28 |
| G | LYS85 |
| G | PGE302 |
| site_id | CC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGE G 302 |
| Chain | Residue |
| G | ARG134 |
| G | SER166 |
| G | PGE301 |
| G | HOH426 |
| G | HOH429 |
| G | HOH468 |
| site_id | CC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 G 303 |
| Chain | Residue |
| F | LYS206 |
| G | ARG134 |
| G | LYS168 |
| G | HOH468 |
| G | HOH486 |
| G | HOH547 |
| site_id | DC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL G 304 |
| Chain | Residue |
| G | HIS150 |
| G | VAL162 |
| G | GLU182 |
| site_id | DC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGE H 301 |
| Chain | Residue |
| H | ASP6 |
| H | ASN28 |
| H | LYS85 |
| H | PHE131 |
| H | PGE302 |
| site_id | DC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PGE H 302 |
| Chain | Residue |
| H | ASN28 |
| H | ARG134 |
| H | SER166 |
| H | PGE301 |
| H | HOH453 |
| H | HOH468 |
| H | HOH516 |
| site_id | DC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 H 303 |
| Chain | Residue |
| G | LYS206 |
| H | ARG134 |
| H | LYS168 |
| H | HOH516 |
| site_id | DC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL H 304 |
| Chain | Residue |
| H | HIS150 |
| H | VAL162 |
| H | GLU182 |
| site_id | DC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGE I 301 |
| Chain | Residue |
| I | ASP6 |
| I | ASN28 |
| I | LYS85 |
| I | PHE131 |
| I | PGE302 |
| site_id | DC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGE I 302 |
| Chain | Residue |
| I | ARG134 |
| I | SER166 |
| I | PGE301 |
| I | HOH424 |
| I | HOH463 |
| site_id | DC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 I 303 |
| Chain | Residue |
| H | LYS206 |
| I | ARG134 |
| I | LYS168 |
| I | HOH490 |
| site_id | DC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL I 304 |
| Chain | Residue |
| I | HIS150 |
| I | VAL162 |
| I | GLU182 |
| site_id | EC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGE J 301 |
| Chain | Residue |
| J | ASP6 |
| J | ASN28 |
| J | LYS85 |
| J | PHE131 |
| J | PGE302 |
| site_id | EC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGE J 302 |
| Chain | Residue |
| J | ARG134 |
| J | SER166 |
| J | PGE301 |
| J | HOH419 |
| J | HOH449 |
| J | HOH526 |
| site_id | EC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 J 303 |
| Chain | Residue |
| J | ARG134 |
| J | LYS168 |
| J | HOH502 |
| J | HOH526 |
| J | HOH548 |
| site_id | EC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL J 304 |
| Chain | Residue |
| J | HIS150 |
| J | VAL162 |
| J | GLU182 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | ACT_SITE: Schiff-base intermediate with substrate => ECO:0000269|PubMed:11120740, ECO:0000269|PubMed:12051943 |
| Chain | Residue | Details |
| A | LYS85 | |
| B | LYS85 | |
| C | LYS85 | |
| D | LYS85 | |
| E | LYS85 | |
| F | LYS85 | |
| G | LYS85 | |
| H | LYS85 | |
| I | LYS85 | |
| J | LYS85 |
