4R7W
Crystal structure of 5-methylcytosine deaminase from Klebsiella pneumoniae liganded with phosphonocytosine
Replaces: 4JNSFunctional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004131 | molecular_function | cytosine deaminase activity |
| A | 0006209 | biological_process | cytosine catabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016810 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| A | 0035888 | molecular_function | isoguanine deaminase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0102480 | molecular_function | 5-fluorocytosine deaminase activity |
| B | 0004131 | molecular_function | cytosine deaminase activity |
| B | 0006209 | biological_process | cytosine catabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016810 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| B | 0035888 | molecular_function | isoguanine deaminase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0102480 | molecular_function | 5-fluorocytosine deaminase activity |
| C | 0004131 | molecular_function | cytosine deaminase activity |
| C | 0006209 | biological_process | cytosine catabolic process |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016810 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| C | 0035888 | molecular_function | isoguanine deaminase activity |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0102480 | molecular_function | 5-fluorocytosine deaminase activity |
| D | 0004131 | molecular_function | cytosine deaminase activity |
| D | 0006209 | biological_process | cytosine catabolic process |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016810 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| D | 0035888 | molecular_function | isoguanine deaminase activity |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0102480 | molecular_function | 5-fluorocytosine deaminase activity |
| E | 0004131 | molecular_function | cytosine deaminase activity |
| E | 0006209 | biological_process | cytosine catabolic process |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0016810 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| E | 0035888 | molecular_function | isoguanine deaminase activity |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0102480 | molecular_function | 5-fluorocytosine deaminase activity |
| F | 0004131 | molecular_function | cytosine deaminase activity |
| F | 0006209 | biological_process | cytosine catabolic process |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0016810 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| F | 0035888 | molecular_function | isoguanine deaminase activity |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0102480 | molecular_function | 5-fluorocytosine deaminase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FE2 A 501 |
| Chain | Residue |
| A | HIS56 |
| A | HIS58 |
| A | HIS209 |
| A | HIS241 |
| A | ASP308 |
| A | O7U502 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE O7U A 502 |
| Chain | Residue |
| A | GLN151 |
| A | HIS209 |
| A | GLU212 |
| A | HIS241 |
| A | GLU273 |
| A | LEU277 |
| A | ASP308 |
| A | TRP314 |
| A | FE2501 |
| A | HOH605 |
| A | HIS58 |
| A | LEU76 |
| A | PHE149 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PEG A 503 |
| Chain | Residue |
| A | ASP327 |
| A | ALA328 |
| A | HIS331 |
| B | ASP327 |
| B | ALA328 |
| B | HIS331 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 504 |
| Chain | Residue |
| A | ASP214 |
| A | PRO216 |
| A | ARG287 |
| A | HOH679 |
| B | PRO285 |
| D | ASP249 |
| D | HOH657 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 505 |
| Chain | Residue |
| A | ASP376 |
| A | ARG386 |
| A | GLN387 |
| A | ALA388 |
| A | ARG389 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FE2 B 501 |
| Chain | Residue |
| B | HIS56 |
| B | HIS58 |
| B | HIS209 |
| B | HIS241 |
| B | ASP308 |
| B | O7U502 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE O7U B 502 |
| Chain | Residue |
| B | HIS58 |
| B | LEU76 |
| B | PHE149 |
| B | GLN151 |
| B | ILE178 |
| B | HIS209 |
| B | GLU212 |
| B | HIS241 |
| B | GLU273 |
| B | LEU277 |
| B | ASP308 |
| B | TRP314 |
| B | FE2501 |
| B | HOH609 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 503 |
| Chain | Residue |
| B | SER254 |
| B | PHE257 |
| B | ARG258 |
| B | HOH783 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FE2 C 501 |
| Chain | Residue |
| C | HIS56 |
| C | HIS58 |
| C | HIS209 |
| C | HIS241 |
| C | ASP308 |
| C | O7U502 |
| site_id | BC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE O7U C 502 |
| Chain | Residue |
| C | HIS58 |
| C | LEU76 |
| C | PHE149 |
| C | GLN151 |
| C | HIS209 |
| C | GLU212 |
| C | HIS241 |
| C | GLU273 |
| C | LEU277 |
| C | ASP308 |
| C | TRP314 |
| C | FE2501 |
| C | HOH601 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL C 503 |
| Chain | Residue |
| C | SER254 |
| C | PHE257 |
| C | ARG292 |
| C | GLU295 |
| C | HOH668 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG C 504 |
| Chain | Residue |
| C | ALA328 |
| E | ASP327 |
| E | ALA328 |
| site_id | BC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PEG C 505 |
| Chain | Residue |
| A | LYS255 |
| C | PRO179 |
| C | HIS180 |
| C | GLU182 |
| C | THR184 |
| C | ARG185 |
| C | GLN217 |
| C | PHE220 |
| C | HOH692 |
| C | HOH743 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO C 506 |
| Chain | Residue |
| C | GLU404 |
| C | VAL405 |
| C | GLU406 |
| C | HOH681 |
| E | VAL405 |
| C | ARG389 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FE2 D 501 |
| Chain | Residue |
| D | HIS56 |
| D | HIS58 |
| D | HIS209 |
| D | HIS241 |
| D | ASP308 |
| D | O7U502 |
| site_id | BC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE O7U D 502 |
| Chain | Residue |
| D | HIS58 |
| D | LEU76 |
| D | GLN151 |
| D | HIS209 |
| D | GLU212 |
| D | HIS241 |
| D | GLU273 |
| D | LEU277 |
| D | ASP308 |
| D | TRP314 |
| D | FE2501 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PEG D 503 |
| Chain | Residue |
| D | ASP327 |
| D | ALA328 |
| D | HIS331 |
| F | ASP327 |
| F | ALA328 |
| F | HIS331 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO D 504 |
| Chain | Residue |
| D | ARG72 |
| D | ARG280 |
| F | ARG298 |
| F | HIS334 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FE2 E 501 |
| Chain | Residue |
| E | HIS56 |
| E | HIS58 |
| E | HIS209 |
| E | HIS241 |
| E | ASP308 |
| E | O7U502 |
| site_id | CC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE O7U E 502 |
| Chain | Residue |
| E | HIS58 |
| E | LEU76 |
| E | PHE149 |
| E | GLN151 |
| E | ILE178 |
| E | HIS209 |
| E | GLU212 |
| E | HIS241 |
| E | GLU273 |
| E | LEU277 |
| E | ASP308 |
| E | TRP314 |
| E | FE2501 |
| E | HOH607 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO E 503 |
| Chain | Residue |
| E | ASN319 |
| E | ASN321 |
| E | ARG324 |
| E | GLN387 |
| site_id | CC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG E 504 |
| Chain | Residue |
| E | ALA65 |
| E | HOH830 |
| E | HOH840 |
| site_id | CC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FE2 F 501 |
| Chain | Residue |
| F | HIS56 |
| F | HIS58 |
| F | HIS209 |
| F | HIS241 |
| F | ASP308 |
| F | O7U502 |
| site_id | CC6 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE O7U F 502 |
| Chain | Residue |
| F | HIS58 |
| F | LEU76 |
| F | GLN151 |
| F | ILE178 |
| F | HIS209 |
| F | GLU212 |
| F | HIS241 |
| F | GLU273 |
| F | LEU277 |
| F | ASP308 |
| F | TRP314 |
| F | FE2501 |
