4R5M
Crystal structure of Vc-Aspartate beta-semialdehyde-dehydrogenase with NADP and 4-Nitro-2-Phosphono-Benzoic acid
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
A | 0006520 | biological_process | amino acid metabolic process |
A | 0008652 | biological_process | amino acid biosynthetic process |
A | 0009085 | biological_process | lysine biosynthetic process |
A | 0009086 | biological_process | methionine biosynthetic process |
A | 0009088 | biological_process | threonine biosynthetic process |
A | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
A | 0009097 | biological_process | isoleucine biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
A | 0019877 | biological_process | diaminopimelate biosynthetic process |
A | 0046983 | molecular_function | protein dimerization activity |
A | 0050661 | molecular_function | NADP binding |
A | 0051287 | molecular_function | NAD binding |
A | 0071266 | biological_process | 'de novo' L-methionine biosynthetic process |
B | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
B | 0006520 | biological_process | amino acid metabolic process |
B | 0008652 | biological_process | amino acid biosynthetic process |
B | 0009085 | biological_process | lysine biosynthetic process |
B | 0009086 | biological_process | methionine biosynthetic process |
B | 0009088 | biological_process | threonine biosynthetic process |
B | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
B | 0009097 | biological_process | isoleucine biosynthetic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
B | 0019877 | biological_process | diaminopimelate biosynthetic process |
B | 0046983 | molecular_function | protein dimerization activity |
B | 0050661 | molecular_function | NADP binding |
B | 0051287 | molecular_function | NAD binding |
B | 0071266 | biological_process | 'de novo' L-methionine biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA A 401 |
Chain | Residue |
A | GLY210 |
A | PHE212 |
A | THR214 |
A | HOH533 |
A | HOH640 |
A | HOH698 |
site_id | AC2 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE NAP A 402 |
Chain | Residue |
A | MET11 |
A | VAL12 |
A | THR36 |
A | SER37 |
A | CYS71 |
A | GLN72 |
A | GLY73 |
A | SER164 |
A | GLY165 |
A | GLN350 |
A | 4NO403 |
A | HOH504 |
A | HOH569 |
A | HOH571 |
A | HOH625 |
A | HOH646 |
A | HOH651 |
A | HOH687 |
A | HOH777 |
A | HOH806 |
A | HOH844 |
A | GLY7 |
A | ARG9 |
A | GLY10 |
site_id | AC3 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE 4NO A 403 |
Chain | Residue |
A | CYS71 |
A | GLY73 |
A | GLY74 |
A | ALA96 |
A | ALA97 |
A | SER98 |
A | ARG101 |
A | ASN133 |
A | LYS243 |
A | NAP402 |
A | HOH747 |
site_id | AC4 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE NAP B 401 |
Chain | Residue |
A | PRO192 |
A | HOH796 |
B | GLY7 |
B | ARG9 |
B | GLY10 |
B | MET11 |
B | VAL12 |
B | THR36 |
B | SER37 |
B | CYS71 |
B | GLN72 |
B | GLY165 |
B | 4NO402 |
B | HOH584 |
B | HOH586 |
B | HOH622 |
B | HOH669 |
site_id | AC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE 4NO B 402 |
Chain | Residue |
B | GLY74 |
B | ALA96 |
B | ALA97 |
B | SER98 |
B | ARG101 |
B | ASN133 |
B | NAP401 |
Functional Information from PROSITE/UniProt
site_id | PS01103 |
Number of Residues | 15 |
Details | ASD Aspartate-semialdehyde dehydrogenase signature. IDgtCvRIgamrCHS |
Chain | Residue | Details |
A | ILE261-SER275 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Acyl-thioester intermediate => ECO:0000269|PubMed:12493825 |
Chain | Residue | Details |
A | CYS134 | |
B | CYS134 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:12493825 |
Chain | Residue | Details |
A | HIS274 | |
B | HIS274 |
site_id | SWS_FT_FI3 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12493825 |
Chain | Residue | Details |
A | GLN72 | |
A | SER164 | |
A | PRO192 | |
A | GLN350 | |
B | ARG9 | |
B | THR36 | |
B | GLN72 | |
B | SER164 | |
B | PRO192 | |
B | GLN350 | |
A | ARG9 | |
A | THR36 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_02121 |
Chain | Residue | Details |
B | ARG101 | |
B | LYS243 | |
A | ARG101 | |
A | LYS243 |
site_id | SWS_FT_FI5 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000305|PubMed:12493825 |
Chain | Residue | Details |
B | GLU240 | |
B | ARG267 | |
B | GLN161 | |
A | GLN161 | |
A | GLU240 | |
A | ARG267 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: S-cysteinyl cysteine; in inhibited form |
Chain | Residue | Details |
B | CYS134 | |
A | CYS134 |