4R2A
Egr1/Zif268 zinc fingers in complex with methylated DNA
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 501 |
| Chain | Residue |
| A | THR391 |
| A | ARG420 |
| A | HOH646 |
| A | HOH675 |
| A | HOH692 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 502 |
| Chain | Residue |
| A | HOH604 |
| A | HOH624 |
| B | DG2 |
| B | HOH137 |
| A | LYS394 |
| A | ARG403 |
| A | LYS404 |
| A | PHE405 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 503 |
| Chain | Residue |
| A | CYS340 |
| A | CYS345 |
| A | HIS358 |
| A | HIS362 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 504 |
| Chain | Residue |
| A | CYS370 |
| A | CYS373 |
| A | HIS386 |
| A | HIS390 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 505 |
| Chain | Residue |
| A | CYS398 |
| A | CYS401 |
| A | HIS414 |
| A | HIS418 |
Functional Information from PROSITE/UniProt
| site_id | PS00028 |
| Number of Residues | 23 |
| Details | ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. CpvesCdrrFsrsdeltrHiri..H |
| Chain | Residue | Details |
| A | CYS340-HIS362 | |
| A | CYS370-HIS390 | |
| A | CYS398-HIS418 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | ZN_FING: C2H2-type 1 => ECO:0000255|PROSITE-ProRule:PRU00042, ECO:0000269|PubMed:25258363, ECO:0000269|PubMed:25999311, ECO:0007744|PDB:4R2A, ECO:0007744|PDB:4R2C, ECO:0007744|PDB:4R2D, ECO:0007744|PDB:4X9J |
| Chain | Residue | Details |
| A | TYR338-HIS362 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 22 |
| Details | ZN_FING: C2H2-type 2 => ECO:0000255|PROSITE-ProRule:PRU00042, ECO:0000269|PubMed:25258363, ECO:0000269|PubMed:25999311, ECO:0007744|PDB:4R2A, ECO:0007744|PDB:4R2C, ECO:0007744|PDB:4R2D, ECO:0007744|PDB:4X9J |
| Chain | Residue | Details |
| A | PHE368-HIS390 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 22 |
| Details | ZN_FING: C2H2-type 3 => ECO:0000255|PROSITE-ProRule:PRU00042, ECO:0000269|PubMed:25258363, ECO:0000269|PubMed:25999311, ECO:0007744|PDB:4R2A, ECO:0007744|PDB:4R2C, ECO:0007744|PDB:4R2D, ECO:0007744|PDB:4X9J |
| Chain | Residue | Details |
| A | PHE396-HIS418 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | SITE: Interaction with DNA => ECO:0000269|PubMed:25258363, ECO:0007744|PDB:4R2A |
| Chain | Residue | Details |
| A | ARG336 | |
| A | ARG357 | |
| A | ARG379 | |
| A | ARG407 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | SITE: Interaction with DNA => ECO:0000250|UniProtKB:P08046 |
| Chain | Residue | Details |
| A | ARG347 | |
| A | ARG351 | |
| A | ARG375 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | SITE: Interaction with DNA => ECO:0000269|PubMed:25999311, ECO:0007744|PDB:4X9J |
| Chain | Residue | Details |
| A | ARG403 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | SITE: Interaction with DNA => ECO:0000269|PubMed:25258363, ECO:0000269|PubMed:25999311, ECO:0007744|PDB:4R2A, ECO:0007744|PDB:4X9J |
| Chain | Residue | Details |
| A | ARG413 |
