4QYI
1.95 Angstrom resolution crystal structure of a hypoxanthine-guanine phosphoribosyltransferase (hpt-2) from Bacillus anthracis str. 'Ames Ancestor' with HEPES molecule in the active site
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006166 | biological_process | purine ribonucleoside salvage |
A | 0006178 | biological_process | guanine salvage |
A | 0016757 | molecular_function | glycosyltransferase activity |
A | 0032263 | biological_process | GMP salvage |
A | 0032264 | biological_process | IMP salvage |
A | 0046100 | biological_process | hypoxanthine metabolic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
B | 0000166 | molecular_function | nucleotide binding |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006166 | biological_process | purine ribonucleoside salvage |
B | 0006178 | biological_process | guanine salvage |
B | 0016757 | molecular_function | glycosyltransferase activity |
B | 0032263 | biological_process | GMP salvage |
B | 0032264 | biological_process | IMP salvage |
B | 0046100 | biological_process | hypoxanthine metabolic process |
B | 0046872 | molecular_function | metal ion binding |
B | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
C | 0000166 | molecular_function | nucleotide binding |
C | 0000287 | molecular_function | magnesium ion binding |
C | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0006166 | biological_process | purine ribonucleoside salvage |
C | 0006178 | biological_process | guanine salvage |
C | 0016757 | molecular_function | glycosyltransferase activity |
C | 0032263 | biological_process | GMP salvage |
C | 0032264 | biological_process | IMP salvage |
C | 0046100 | biological_process | hypoxanthine metabolic process |
C | 0046872 | molecular_function | metal ion binding |
C | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
D | 0000166 | molecular_function | nucleotide binding |
D | 0000287 | molecular_function | magnesium ion binding |
D | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0006166 | biological_process | purine ribonucleoside salvage |
D | 0006178 | biological_process | guanine salvage |
D | 0016757 | molecular_function | glycosyltransferase activity |
D | 0032263 | biological_process | GMP salvage |
D | 0032264 | biological_process | IMP salvage |
D | 0046100 | biological_process | hypoxanthine metabolic process |
D | 0046872 | molecular_function | metal ion binding |
D | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
E | 0000166 | molecular_function | nucleotide binding |
E | 0000287 | molecular_function | magnesium ion binding |
E | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
E | 0005737 | cellular_component | cytoplasm |
E | 0005829 | cellular_component | cytosol |
E | 0006166 | biological_process | purine ribonucleoside salvage |
E | 0006178 | biological_process | guanine salvage |
E | 0016757 | molecular_function | glycosyltransferase activity |
E | 0032263 | biological_process | GMP salvage |
E | 0032264 | biological_process | IMP salvage |
E | 0046100 | biological_process | hypoxanthine metabolic process |
E | 0046872 | molecular_function | metal ion binding |
E | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MG A 201 |
Chain | Residue |
A | GLU98 |
A | ASP99 |
A | PO4202 |
A | HOH308 |
A | HOH314 |
A | HOH321 |
A | HOH326 |
site_id | AC2 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE PO4 A 202 |
Chain | Residue |
A | GLY43 |
A | ASP158 |
A | ARG164 |
A | MG201 |
A | HOH314 |
A | HOH317 |
A | HOH321 |
A | LEU41 |
A | LYS42 |
site_id | AC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE PO4 A 203 |
Chain | Residue |
A | ILE101 |
A | ASP102 |
A | SER103 |
A | GLY104 |
A | LEU105 |
A | THR106 |
A | LEU107 |
A | HOH331 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG B 201 |
Chain | Residue |
B | GLU98 |
B | ASP99 |
B | HOH335 |
B | HOH355 |
B | HOH365 |
B | HOH383 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG B 202 |
Chain | Residue |
B | ASP158 |
B | PO4203 |
B | EPE204 |
B | HOH337 |
B | HOH401 |
B | HOH402 |
site_id | AC6 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE PO4 B 203 |
Chain | Residue |
B | LEU41 |
B | LYS42 |
B | GLY43 |
B | ASP158 |
B | ARG164 |
B | MG202 |
B | EPE204 |
B | HOH333 |
B | HOH335 |
B | HOH336 |
B | HOH355 |
B | HOH385 |
site_id | AC7 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE EPE B 204 |
Chain | Residue |
B | ILE101 |
B | ASP102 |
B | SER103 |
B | GLY104 |
B | LEU105 |
B | THR106 |
B | LEU107 |
B | MG202 |
B | PO4203 |
B | HOH383 |
site_id | AC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG C 201 |
Chain | Residue |
C | GLU98 |
C | ASP99 |
C | HOH352 |
C | HOH360 |
C | HOH361 |
C | HOH377 |
site_id | AC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG C 202 |
Chain | Residue |
C | ASP158 |
C | PO4203 |
C | HOH348 |
C | HOH359 |
site_id | BC1 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE PO4 C 203 |
Chain | Residue |
C | LEU41 |
C | LYS42 |
C | GLY43 |
C | ASP158 |
C | ARG164 |
C | MG202 |
C | EPE204 |
C | HOH347 |
C | HOH360 |
C | HOH376 |
C | HOH377 |
C | HOH386 |
site_id | BC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EPE C 204 |
Chain | Residue |
C | ILE101 |
C | ASP102 |
C | SER103 |
C | GLY104 |
C | THR106 |
C | LEU107 |
C | PO4203 |
C | HOH352 |
site_id | BC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG D 201 |
Chain | Residue |
D | GLU98 |
D | ASP99 |
D | PO4202 |
D | HOH302 |
D | HOH316 |
D | HOH319 |
site_id | BC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PO4 D 202 |
Chain | Residue |
D | HOH316 |
D | HOH318 |
D | LYS42 |
D | GLY43 |
D | ASP158 |
D | ARG164 |
D | MG201 |
site_id | BC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PO4 D 203 |
Chain | Residue |
D | ASP102 |
D | SER103 |
D | GLY104 |
D | LEU105 |
D | THR106 |
D | LEU107 |
D | HOH306 |
site_id | BC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG E 201 |
Chain | Residue |
E | GLU98 |
E | ASP99 |
E | HOH349 |
E | HOH350 |
E | HOH367 |
E | HOH372 |
site_id | BC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG E 202 |
Chain | Residue |
E | HOH340 |
E | HOH341 |
E | HOH369 |
E | HOH370 |
E | HOH371 |
site_id | BC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG E 203 |
Chain | Residue |
E | ASP158 |
E | PO4205 |
E | EPE207 |
E | HOH373 |
E | HOH374 |
E | HOH381 |
site_id | BC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL E 204 |
Chain | Residue |
E | GLU12 |
E | ARG53 |
E | HIS54 |
E | HOH351 |
E | HOH384 |
site_id | CC1 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE PO4 E 205 |
Chain | Residue |
E | LYS42 |
E | GLY43 |
E | ASP158 |
E | ARG164 |
E | MG203 |
E | EPE207 |
E | HOH346 |
E | HOH349 |
E | HOH366 |
E | HOH372 |
site_id | CC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PO4 E 206 |
Chain | Residue |
E | ILE100 |
E | ILE101 |
E | ASP102 |
E | SER103 |
E | GLY104 |
E | LEU105 |
E | LEU107 |
site_id | CC3 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE EPE E 207 |
Chain | Residue |
E | ASP102 |
E | GLY104 |
E | THR106 |
E | LEU107 |
E | MG203 |
E | PO4205 |
E | HOH350 |
E | HOH374 |
E | HOH381 |
Functional Information from PROSITE/UniProt
site_id | PS00103 |
Number of Residues | 13 |
Details | PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VIVVEDIIDSGlT |
Chain | Residue | Details |
A | VAL94-THR106 | |
B | VAL94-THR106 |