4QM0
Crystal structure of RORc in complex with a tertiary sulfonamide inverse agonist
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0004879 | molecular_function | nuclear receptor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0003677 | molecular_function | DNA binding |
| C | 0004879 | molecular_function | nuclear receptor activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 39K A 601 |
| Chain | Residue |
| A | CYS285 |
| A | LEU391 |
| A | ILE400 |
| A | HIS479 |
| A | ARG482 |
| A | LEU483 |
| A | GLN286 |
| A | LEU287 |
| A | CYS320 |
| A | LEU324 |
| A | ARG364 |
| A | MET365 |
| A | ARG367 |
| A | VAL376 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS A 602 |
| Chain | Residue |
| A | HIS323 |
| A | PHE377 |
| A | GLU379 |
| A | HOH761 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 39K C 601 |
| Chain | Residue |
| C | GLN286 |
| C | LEU287 |
| C | TRP317 |
| C | CYS320 |
| C | HIS323 |
| C | MET365 |
| C | PHE378 |
| C | PHE388 |
| C | LEU391 |
| C | LEU396 |
| C | PHE401 |
| C | HIS479 |
| C | DMS602 |
| C | HOH776 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS C 602 |
| Chain | Residue |
| C | HIS323 |
| C | PHE377 |
| C | PHE378 |
| C | GLU379 |
| C | 39K601 |
| C | HOH751 |
| C | HOH774 |
