4PWN

Crystal structure of Active WNK1 kinase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 A 501

Chain	Residue
A	HIS339
A	GLU401
A	VAL405
A	SER469
A	ILE470
A	HOH642

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Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKcdNIFI

Chain	Residue	Details
A	ILE345-ILE357

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000305|PubMed:16263722

Chain	Residue	Details
A	ASP368

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:27712055, ECO:0000305|PubMed:28771350, ECO:0007744|PDB:5TF9, ECO:0007744|PDB:5WDY, ECO:0007744|PDB:5WE8

Chain	Residue	Details
A	SER231
A	THR301
A	LYS351

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site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q9JIH7

Chain	Residue	Details
A	PHE283
A	LEU299
A	LEU369
A	LEU371

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:31656913

Chain	Residue	Details
A	SER374

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:16832045, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:34289367

Chain	Residue	Details
A	SER374

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