4P6I

Crystal structure of the Cas1-Cas2 complex from Escherichia coli

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004518	molecular_function	nuclease activity
A	0004519	molecular_function	endonuclease activity
A	0005515	molecular_function	protein binding
A	0016787	molecular_function	hydrolase activity
A	0043571	biological_process	maintenance of CRISPR repeat elements
A	0051607	biological_process	defense response to virus
A	0099048	biological_process	CRISPR-cas system
B	0003677	molecular_function	DNA binding
B	0004518	molecular_function	nuclease activity
B	0004519	molecular_function	endonuclease activity
B	0005515	molecular_function	protein binding
B	0016787	molecular_function	hydrolase activity
B	0043571	biological_process	maintenance of CRISPR repeat elements
B	0051607	biological_process	defense response to virus
B	0099048	biological_process	CRISPR-cas system
C	0003676	molecular_function	nucleic acid binding
C	0003677	molecular_function	DNA binding
C	0004518	molecular_function	nuclease activity
C	0004519	molecular_function	endonuclease activity
C	0004520	molecular_function	DNA endonuclease activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0006281	biological_process	DNA repair
C	0006974	biological_process	DNA damage response
C	0008821	molecular_function	crossover junction DNA endonuclease activity
C	0016787	molecular_function	hydrolase activity
C	0017108	molecular_function	5'-flap endonuclease activity
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0043571	biological_process	maintenance of CRISPR repeat elements
C	0046872	molecular_function	metal ion binding
C	0051607	biological_process	defense response to virus
C	0099048	biological_process	CRISPR-cas system
D	0003676	molecular_function	nucleic acid binding
D	0003677	molecular_function	DNA binding
D	0004518	molecular_function	nuclease activity
D	0004519	molecular_function	endonuclease activity
D	0004520	molecular_function	DNA endonuclease activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0006281	biological_process	DNA repair
D	0006974	biological_process	DNA damage response
D	0008821	molecular_function	crossover junction DNA endonuclease activity
D	0016787	molecular_function	hydrolase activity
D	0017108	molecular_function	5'-flap endonuclease activity
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0043571	biological_process	maintenance of CRISPR repeat elements
D	0046872	molecular_function	metal ion binding
D	0051607	biological_process	defense response to virus
D	0099048	biological_process	CRISPR-cas system
E	0003676	molecular_function	nucleic acid binding
E	0003677	molecular_function	DNA binding
E	0004518	molecular_function	nuclease activity
E	0004519	molecular_function	endonuclease activity
E	0004520	molecular_function	DNA endonuclease activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0006281	biological_process	DNA repair
E	0006974	biological_process	DNA damage response
E	0008821	molecular_function	crossover junction DNA endonuclease activity
E	0016787	molecular_function	hydrolase activity
E	0017108	molecular_function	5'-flap endonuclease activity
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0043571	biological_process	maintenance of CRISPR repeat elements
E	0046872	molecular_function	metal ion binding
E	0051607	biological_process	defense response to virus
E	0099048	biological_process	CRISPR-cas system
F	0003676	molecular_function	nucleic acid binding
F	0003677	molecular_function	DNA binding
F	0004518	molecular_function	nuclease activity
F	0004519	molecular_function	endonuclease activity
F	0004520	molecular_function	DNA endonuclease activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0006281	biological_process	DNA repair
F	0006974	biological_process	DNA damage response
F	0008821	molecular_function	crossover junction DNA endonuclease activity
F	0016787	molecular_function	hydrolase activity
F	0017108	molecular_function	5'-flap endonuclease activity
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0043571	biological_process	maintenance of CRISPR repeat elements
F	0046872	molecular_function	metal ion binding
F	0051607	biological_process	defense response to virus
F	0099048	biological_process	CRISPR-cas system

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:26503043, ECO:0007744|PDB:5DS5

Chain	Residue	Details
C	GLU141
C	ASP221
D	GLU141
D	ASP221
E	GLU141
E	ASP221
F	GLU141
F	ASP221

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000305|PubMed:26503043

Chain	Residue	Details
C	HIS208
D	HIS208
E	HIS208
F	HIS208

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