4OXF
Structure of ECP in complex with citrate ions at 1.50 Angstroms
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001530 | molecular_function | lipopolysaccharide binding |
| A | 0002227 | biological_process | innate immune response in mucosa |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0004540 | molecular_function | RNA nuclease activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006401 | biological_process | RNA catabolic process |
| A | 0006935 | biological_process | chemotaxis |
| A | 0019731 | biological_process | antibacterial humoral response |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0043152 | biological_process | induction of bacterial agglutination |
| A | 0045087 | biological_process | innate immune response |
| A | 0050829 | biological_process | defense response to Gram-negative bacterium |
| A | 0050830 | biological_process | defense response to Gram-positive bacterium |
| A | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
| B | 0001530 | molecular_function | lipopolysaccharide binding |
| B | 0002227 | biological_process | innate immune response in mucosa |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0004519 | molecular_function | endonuclease activity |
| B | 0004540 | molecular_function | RNA nuclease activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0006401 | biological_process | RNA catabolic process |
| B | 0006935 | biological_process | chemotaxis |
| B | 0019731 | biological_process | antibacterial humoral response |
| B | 0035578 | cellular_component | azurophil granule lumen |
| B | 0042742 | biological_process | defense response to bacterium |
| B | 0043152 | biological_process | induction of bacterial agglutination |
| B | 0045087 | biological_process | innate immune response |
| B | 0050829 | biological_process | defense response to Gram-negative bacterium |
| B | 0050830 | biological_process | defense response to Gram-positive bacterium |
| B | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue CIT A 301 |
| Chain | Residue |
| A | THR46 |
| A | HOH438 |
| A | HOH506 |
| B | ARG121 |
| A | ASN50 |
| A | SER74 |
| A | ARG75 |
| A | ARG75 |
| A | PHE76 |
| A | TYR107 |
| A | HOH407 |
| A | HOH410 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | binding site for residue CIT A 302 |
| Chain | Residue |
| A | ARG34 |
| A | ARG34 |
| A | CYS37 |
| A | CYS37 |
| A | LYS38 |
| A | LYS38 |
| A | ASN39 |
| A | ASN39 |
| A | GLN40 |
| A | FE304 |
| A | FE304 |
| A | HOH401 |
| A | HOH408 |
| A | HOH422 |
| A | HOH422 |
| A | HOH451 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue CIT A 303 |
| Chain | Residue |
| A | ARG45 |
| A | HOH404 |
| A | HOH425 |
| A | HOH449 |
| A | HOH514 |
| A | HOH596 |
| B | ARG114 |
| B | PRO116 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue FE A 304 |
| Chain | Residue |
| A | CIT302 |
| A | CIT302 |
| A | HOH422 |
| A | HOH451 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | binding site for residue CIT B 301 |
| Chain | Residue |
| A | ARG61 |
| A | ARG66 |
| B | THR46 |
| B | ASN50 |
| B | VAL54 |
| B | ASN57 |
| B | SER74 |
| B | ARG75 |
| B | PHE76 |
| B | VAL78 |
| B | TYR107 |
| B | HOH411 |
| B | HOH412 |
| B | HOH487 |
| B | HOH577 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | binding site for residue CIT B 302 |
| Chain | Residue |
| B | ARG34 |
| B | ARG34 |
| B | ARG36 |
| B | CYS37 |
| B | LYS38 |
| B | LYS38 |
| B | ASN39 |
| B | ASN39 |
| B | FE303 |
| B | FE303 |
| B | HOH401 |
| B | HOH401 |
| B | HOH403 |
| B | HOH405 |
| B | HOH405 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue FE B 303 |
| Chain | Residue |
| B | CIT302 |
| B | CIT302 |
| B | HOH405 |
Functional Information from PROSITE/UniProt
| site_id | PS00127 |
| Number of Residues | 7 |
| Details | RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKnqNTF |
| Chain | Residue | Details |
| A | CYS37-PHE43 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor |
| Chain | Residue | Details |
| A | HIS15 | |
| B | HIS15 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor |
| Chain | Residue | Details |
| A | HIS128 | |
| B | HIS128 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | LYS38 | |
| B | LYS38 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: May be involved in LPS-binding |
| Chain | Residue | Details |
| A | TYR33 | |
| B | TYR33 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: May be involved in LPS- and LTA-binding |
| Chain | Residue | Details |
| A | TRP35 | |
| B | TRP35 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: 3'-nitrotyrosine => ECO:0000269|PubMed:18694936 |
| Chain | Residue | Details |
| A | TYR33 | |
| B | TYR33 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN57 | |
| A | ASN65 | |
| A | ASN92 | |
| B | ASN57 | |
| B | ASN65 | |
| B | ASN92 |
