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4OAV

Complete human RNase L in complex with 2-5A (5'-ppp heptamer), AMPPCP and RNA substrate.

Functional Information from GO Data
ChainGOidnamespacecontents
B0000166molecular_functionnucleotide binding
B0003723molecular_functionRNA binding
B0004518molecular_functionnuclease activity
B0004519molecular_functionendonuclease activity
B0004521molecular_functionRNA endonuclease activity
B0004540molecular_functionRNA nuclease activity
B0004672molecular_functionprotein kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005575cellular_componentcellular_component
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0005829cellular_componentcytosol
B0006364biological_processrRNA processing
B0006396biological_processRNA processing
B0006397biological_processmRNA processing
B0006468biological_processprotein phosphorylation
B0016363cellular_componentnuclear matrix
B0016787molecular_functionhydrolase activity
B0019843molecular_functionrRNA binding
B0043021molecular_functionribonucleoprotein complex binding
B0043488biological_processregulation of mRNA stability
B0045071biological_processnegative regulation of viral genome replication
B0045444biological_processfat cell differentiation
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046326biological_processpositive regulation of glucose import
B0046872molecular_functionmetal ion binding
B0051252biological_processregulation of RNA metabolic process
B0051607biological_processdefense response to virus
D0000166molecular_functionnucleotide binding
D0003723molecular_functionRNA binding
D0004518molecular_functionnuclease activity
D0004519molecular_functionendonuclease activity
D0004521molecular_functionRNA endonuclease activity
D0004540molecular_functionRNA nuclease activity
D0004672molecular_functionprotein kinase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005575cellular_componentcellular_component
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005759cellular_componentmitochondrial matrix
D0005829cellular_componentcytosol
D0006364biological_processrRNA processing
D0006396biological_processRNA processing
D0006397biological_processmRNA processing
D0006468biological_processprotein phosphorylation
D0016363cellular_componentnuclear matrix
D0016787molecular_functionhydrolase activity
D0019843molecular_functionrRNA binding
D0043021molecular_functionribonucleoprotein complex binding
D0043488biological_processregulation of mRNA stability
D0045071biological_processnegative regulation of viral genome replication
D0045444biological_processfat cell differentiation
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046326biological_processpositive regulation of glucose import
D0046872molecular_functionmetal ion binding
D0051252biological_processregulation of RNA metabolic process
D0051607biological_processdefense response to virus
Functional Information from PDB Data
site_idAC1
Number of Residues25
DetailsBINDING SITE FOR RESIDUE ACP B 801
ChainResidue
BILE371
BTHR435
BCYS437
BTHR440
BGLN489
BASN490
BLEU492
BASP503
BASP505
BMG802
BMG803
BALA372
BHOH907
BHOH918
BHOH926
BHOH955
BHOH989
BHOH1072
BTHR374
BSER375
BILE379
BALA390
BLYS392
BARG400
BVAL434

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG B 802
ChainResidue
BASN490
BASP503
BACP801
BHOH907
BHOH918

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG B 803
ChainResidue
BASP485
BASP503
BASP505
BACP801
BHOH926
BHOH1143

site_idAC4
Number of Residues30
DetailsBINDING SITE FOR RESIDUE ACP D 1001
ChainResidue
DILE371
DALA372
DTHR374
DSER375
DILE379
DALA390
DLYS392
DARG400
DVAL434
DTHR435
DCYS437
DTHR440
DGLN489
DASN490
DLEU492
DASP503
DASP505
DMG1002
DMG1003
DHOH1122
DHOH1147
DHOH1191
DHOH1196
DHOH1242
DHOH1281
DHOH1318
DHOH1402
DHOH1468
DHOH1492
DHOH1493

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG D 1002
ChainResidue
DASN490
DASP503
DACP1001
DHOH1122
DHOH1492

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG D 1003
ChainResidue
DASP503
DASP505
DACP1001
DHOH1493
DHOH1494

site_idAC7
Number of Residues12
DetailsBINDING SITE FOR RESIDUE PUP D 1004
ChainResidue
DLYS606
DTHR607
DMET644
DPHE647
DTYR648
DARG651
DARG667
DASN668
DASN672
DHOH1128
DHOH1270
DHOH1350

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues98
DetailsZN_FING: C6-type; atypical
ChainResidueDetails
BCYS395-CYS444
DCYS395-CYS444

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
BLYS684
DLYS684

218853

PDB entries from 2024-04-24

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