4O5O
X-ray Crystal Structure of a 3-hydroxyacyl-CoA dehydrogenase from Brucella suis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004303 | molecular_function | estradiol 17-beta-dehydrogenase [NAD(P)] activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006706 | biological_process | steroid catabolic process |
| A | 0008209 | biological_process | androgen metabolic process |
| A | 0008210 | biological_process | estrogen metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004303 | molecular_function | estradiol 17-beta-dehydrogenase [NAD(P)] activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006706 | biological_process | steroid catabolic process |
| B | 0008209 | biological_process | androgen metabolic process |
| B | 0008210 | biological_process | estrogen metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 301 |
| Chain | Residue |
| A | HIS-4 |
| A | HIS231 |
| A | GLU235 |
| B | HIS-3 |
| B | HIS-5 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B 301 |
| Chain | Residue |
| B | GLY97 |
| B | ARG98 |
| B | HOH615 |
| B | HOH688 |
| A | ARG181 |
| A | HIS182 |
| A | HOH449 |
| B | LEU96 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B 302 |
| Chain | Residue |
| A | HOH426 |
| B | VAL37 |
| B | ASN38 |
| B | ALA39 |
| B | GLU40 |
| B | HOH475 |
| B | HOH525 |
| B | HOH627 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE TRS B 303 |
| Chain | Residue |
| A | GLU242 |
| A | VAL243 |
| A | ARG245 |
| B | PHE152 |
| B | GLU242 |
| B | VAL243 |
| B | ARG245 |
| B | HOH432 |
| B | HOH445 |
| B | HOH451 |
| B | HOH493 |
| B | HOH534 |
| B | HOH549 |
| B | HOH570 |
| B | HOH579 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvaafdgqigQaaYSASKGGVaAMTlPVA |
| Chain | Residue | Details |
| A | SER148-ALA176 |
